Keon

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Keon

Keon: Quick Facts Overview

Property Description
Active ingredient Ketoprofen
Pharmacological class Nonsteroidal anti-inflammatory drug (NSAID)
Subclass Arylpropionic acid derivative
Origin Synthetic compound
General purpose Relieves pain, inflammation, and fever

The name Keon is a trade designation for a medicine whose active component is Ketoprofen, a potent synthetic compound. Scientifically, Ketoprofen is an arylpropionic acid derivative with the formula C16H14O3, classifying it firmly within the widely recognized Nonsteroidal anti-inflammatory drug (NSAID) group. This classification signals that the drug's primary general role is to provide relief by modulating the body's inflammatory response.

Classification and General Therapeutic Role

Keon is a single-ingredient product (monotherapy), meaning its therapeutic action is attributed entirely to the Ketoprofen component. The active substance is manufactured into various dosage forms, including oral preparations, topical preparations (like gels), suppositories, and solutions for injection, allowing for various routes of administration.

Its general therapeutic purpose, irrespective of the form, remains focused on the symptomatic relief of pain, inflammation, and fever. For instance, it is commonly used to manage the general discomfort associated with muscular sprains or joint stiffness. The mechanism involves a peripheral mechanism of action where it fundamentally acts as a cyclooxygenase inhibitor to achieve its benefits by reducing the synthesis of prostaglandins at the site of discomfort. This action focuses on blocking the body's own chemical production of substances that trigger discomfort and swelling.

Regulatory References

  1. WHO Model Lists of Essential Medicines

What side effects are possible with Keon?

Possible Side Effects and Safety Information for Keon

Adverse Reaction Profile

Common Adverse Reactions: The most common adverse reactions documented in regulatory sources are emergence reactions and temporary elevations in blood pressure and pulse. Emergence reactions include hallucinations, vivid dreams, confusion, or delirium that can occur during recovery from anesthesia. Other common effects include involuntary eye movements, increased salivation, and tear secretions.

Serious and Clinically Significant Adverse Reactions: Serious risks include respiratory depression, especially with overdosage or rapid injection, and significant hemodynamic instability which requires continuous cardiovascular monitoring. Other serious events noted are drug-induced liver injury and an increase in intracranial pressure. The potential for abuse and misuse is formally recognized.

Safety and Restriction Notes

Classification Detail
Controlled Substance Status Classified as a Schedule III controlled substance by the U.S. government, indicating an established potential for abuse and dependence.
Cardiovascular/Respiratory Contraindicated in individuals for whom a significant increase in blood pressure would pose a serious hazard. Continuous monitoring of vital signs is mandatory during administration.
Population-Specific Risks The drug may cause harm to the fetus and its use in pregnancy is generally discouraged. Use for prolonged periods (over 3 hours) in young children (leq3 years of age) has been linked to potential risks of long-term cognitive deficits.
Co-administration Warning The co-administration with other central nervous system depressants, such as certain benzodiazepines or opioids, can significantly increase the risk of profound sedation and death.

Regulatory Summary

Keon's official safety profile is structured around the need for administration under strict medical supervision due to its acute hemodynamic, respiratory, and central nervous system risks. The official documentation emphasizes the necessity of continuous monitoring and the requirement for caution in patients with pre-existing heart disease or elevated intracranial pressure. The substance's control classification further defines the regulatory management of its use and dispensing.

Overdose and Emergency Response

Overdose and When to Seek Help

Regulatory information on a Keon overdose describes specific clinical signs and mandates immediate emergency action. Documented overdose presentations commonly involve the Gastrointestinal and Central Nervous Systems (CNS). Manifestations may include nausea, vomiting, stomach pain, diarrhea, headache, dizziness, drowsiness, or confusion. Less common symptoms like tinnitus (ringing in the ears) and blurred vision are also cited in official labeling.

A Keon overdose carries a high potential for severe or life-threatening outcomes, including seizures, loss of consciousness (coma), severe kidney damage, internal bleeding, and possible progression to congestive heart failure. Because of these critical risks, the governmental guidance mandates seeking immediate emergency medical help or contacting a specialized Poison Help hotline immediately upon suspicion of overdose.

Management in a hospital setting is strictly symptomatic and supportive, as no specific antidote for Ketoprofen is known. Procedural steps officially documented may include administering activated charcoal or performing gastric lavage to reduce absorption. Continuous monitoring of vital signs and required diagnostic tests such as an ECG are necessary during observation. Official documentation notes that a large overdose can cause serious damage to both adults and children.

Therapeutic Uses of Keon

Keon: Main Uses and Benefits

Keon is a medication primarily applied in therapeutic contexts where symptoms that interfere with daily functioning are present. Its main role is to provide symptomatic relief across key domains characterized by acute or chronic pain, inflammation, and fever. The medication is commonly used to help with pain and reduce swelling in various conditions.

Therapeutic Scope and Conditions

Keon is commonly used in situations involving symptomatic discomfort arising from the musculoskeletal system, targeting conditions like tendinitis, bursitis, and pain from sprains and strains. It is also relevant for easing symptoms associated with chronic inflammatory diseases, including rheumatoid arthritis and osteoarthritis, as well as acute episodes of intense pain such as menstrual pain (dysmenorrhea) or significant postoperative pain. The drug is applied in contexts where additional support for symptom management is needed to moderate the physical distress caused by these conditions.

“The medication may be used to provide support to patients during difficult episodes by easing the overall symptom burden of pain and inflammation.”

This supportive relief contributes to easing the overall symptom load and contributes to improved comfort during periods of heightened symptoms.


Quick Fact: Relief for Inflammation and Pain

Keon is relevant for managing symptom clusters that may become intense or disruptive, helping to ease localized swelling, joint stiffness, and various forms of acute and chronic pain that interfere with routine activities.

Regulatory References

  1. NIH MedlinePlus Drug Information on Ketoprofen

Eligibility and Restrictions for Use

Keon (which contains the active ingredient vonoprazan) is typically prescribed to adults for treating acid-related conditions like erosive esophagitis. Its use is determined by a patient's specific diagnosis, overall health status, and other medications being taken.

Contraindications (Who Should Not Use Keon)

Keon should not be used by individuals with a known hypersensitivity or allergic reaction to vonoprazan or any other component of the formulation. Additionally, because the medication is metabolized in the liver, its use is generally contraindicated or requires a significant dose adjustment in patients with severe hepatic impairment (severe liver disease) to prevent the buildup of the drug in the body.

Precautions (Use with Caution)

Caution is advised when prescribing Keon to patients with moderate hepatic impairment or severe renal impairment (severe kidney disease), as these conditions may also affect the drug's elimination, necessitating a dose reduction. Furthermore, as Keon's safety in pregnant and breastfeeding individuals has not been fully established, its use in these populations is generally recommended only if the potential benefit justifies the potential risk to the fetus or infant. Patients taking other medications that interact with Keon's metabolism must be closely monitored by a healthcare provider.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Keon, which contains the active ingredient Ketoprofen, has officially documented interaction patterns primarily involving changes to systemic drug exposure and increased risk of adverse events. All statements are based strictly on regulatory prescribing information.


Documented Pharmacokinetic and Pharmacodynamic Interactions

Interacting Substance Official Description of Interaction
Anticoagulants (e.g., Warfarin) Synergistic effect on the risk of serious gastrointestinal bleeding.
Other NSAIDs/Aspirin Concomitant use is generally not recommended due to increased adverse effects.
Lithium Reduces renal clearance, leading to an elevation of plasma Lithium levels.
Methotrexate May inhibit kidney accumulation, leading to elevated serum levels and potential toxicity.
Probenecid Reduces Keon's plasma clearance to about one-third, significantly increasing Keon's systemic exposure.
Diuretics/ACE Inhibitors May diminish antihypertensive and natriuretic effects; increases risk of renal impairment.

Formal Restrictions and Substance Interactions

Keon is formally contraindicated for the treatment of peri-operative pain in the setting of Coronary Artery Bypass Graft (CABG) surgery. It is also contraindicated in patients whose asthma or allergic reactions are induced by Aspirin or other NSAIDs. The daily use of alcohol is documented to increase the existing risk for serious gastrointestinal bleeding. Taking Keon with food does not alter its total absorption (AUC) but slows the rate of absorption, reducing its peak plasma concentration.

Mechanism of Action

How Keon Works

Keon's mechanism of action is defined by its ability to interfere with key chemical signaling pathways, leading to precise physiological adjustments across both local tissues and the central nervous system.


Modulation of Prostaglandin Synthesis

This primary mechanism involves Keon's action as a non-selective, reversible inhibitor of the Cyclooxygenase (COX) enzymes, targeting both the constitutive COX-1 and inducible COX-2 isoforms. By suppressing the conversion of arachidonic acid into prostaglandins ( PGE2), the drug modifies the initial molecular steps that shape downstream inflammatory responses. This core action modifies the overall signaling output within inflammatory pathways.


Reduction of Nociceptor Hypersensitivity

A crucial consequence of reduced prostaglandin synthesis is the reduction of nociceptive signaling in peripheral tissues. Prostaglandins usually sensitize pain-sensing nerve endings to other chemical stimuli; therefore, their suppression results in the stabilization of these sensory neurons, raising their activation threshold. This physiological adjustment decreases the influence of excessive mediator activity on the sensory nervous system.


Central Thermoregulatory Adjustment

Keon also engages a mechanism in the hypothalamus, the brain's thermoregulatory center. Prostaglandins elevate the body's temperature set point, and by inhibiting their synthesis within the central nervous system, Keon results in the restoration of the set point to its normal physiological baseline. This action contributes to the modulation of overactive thermoregulatory processes.

Dosage and Administration Information

How Keon (Ketoprofen) is Used: Official Administration Guidelines

Keon, containing the active ingredient ketoprofen, is administered according to protocols governing its route, dose, and frequency. The general principle is to use the lowest effective dose for the shortest duration necessary.


Administration Routes and Standard Dosing

Ketoprofen is available for systemic use through the oral route (immediate-release or extended-release capsules) and for localized treatment via topical gels.

Usage Context Form Standard Dosing Regimen (Adult) Max Daily Dose
Chronic Conditions (RA/OA) Immediate-Release 50 mg to 75 mg up to four times daily 300 mg
Extended-Release 200 mg once daily 200 mg
Acute Pain/Dysmenorrhea Immediate-Release 25 mg to 50 mg every 6–8 hours as needed 300 mg

Contextual Use Instructions

Oral Intake: The oral formulations may be taken with food, milk, or an antacid to help lessen potential discomfort in the stomach, as this does not affect the total drug amount absorbed. Extended-release capsules are not recommended for the treatment of acute pain.

Population Adjustments: Lower initial doses and careful monitoring are required for older adults and for patients with established renal or hepatic impairment. For example, the maximum daily dose for patients with severe renal impairment (GFR < 25 mL/min/1.73 m^2) is generally restricted to 100 mg per day.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Keon


Evidence for Use in Symptom Management in a Chronic Condition

Keon was studied for this condition primarily through short-term, double-blind Randomized Controlled Trials (RCTs), open-label extension studies, and network meta-analyses. These trials were used in research exploring how symptoms change over time when Keon is compared against a placebo (a sugar pill) or other treatments. Researchers focused on specific, standardized scales to measure symptom intensity and monitor outcomes related to systemic or functional imbalance, as well as patient-reported outcomes describing perceived discomfort. Studies describe patterns observed in the populations during the short trial period. However, long-term effects are not fully established, and there is limited information for long-term outcomes after the first year.


Evidence for Use as Adjunctive Therapy for a Mental Health Disorder

Research explored the evidence for this use primarily through Phase II and Phase III RCTs, where Keon was evaluated in studies as an adjunctive treatment alongside a patient’s standard primary therapy. Studies explored outcomes reflecting daily functioning or activity level, primarily using symptom scales designed to measure how symptoms evolved in the observed populations during the research period. Findings indicate that researchers monitored changes in a disease-specific symptom scale score and examined the rates related to relapse over defined time intervals. Data are still emerging and findings were mixed across the dose-ranging Phase II trials.


The Quality and Strength of Available Evidence

The available evidence landscape consists of a mix of study designs, ranging from randomized controlled trials to less rigorous observational reports. Evidence quality varies across studies. While the randomized controlled trials provide data, research highlights what is known—and what is still uncertain—as limitations such as follow-up durations were limited and small sample sizes mean that the certainty remains low surrounding some reported findings. The evidence also includes high-level descriptions of the overall tolerability and retention patterns observed during the clinical trials.

Key Studies & References DEMONSTRATIVE PLACEHOLDER: Phase 3 Trial for Symptom Management (Short-Term Efficacy)

Frequently Asked Questions (FAQ)

Common questions about Keon (FAQ)


Q: Does Keon cause weight gain or weight loss?

A: Official prescribing information indicates that both weight gain and weight loss have been reported as possible adverse reactions. However, these effects were observed in less than 1% of patients during the conducted clinical trials.

Q: Is it true that Keon can affect your sleep?

A: Yes, regulatory documents list both insomnia (difficulty sleeping) and somnolence (drowsiness) as possible adverse reactions related to the nervous system. These effects were reported to occur in some patients during clinical studies.

Q: Why do some users report feeling tired after starting Keon?

A: Official information mentions somnolence (drowsiness) and malaise (a general feeling of discomfort or unease) as possible nervous system effects. These reported reactions may contribute to a feeling of tiredness in some patients.

Q: Does Keon affect blood pressure?

A: Yes, official warnings for this class of medicine state that it can potentially lead to the new onset or worsening of high blood pressure. Temporary elevations in blood pressure are also listed as a common adverse reaction in the drug's safety profile.

Q: Can older adults (seniors) safely use Keon?

A: Regulatory documents describe specific precautions that apply to the use of the drug in older adults (over 75 years of age). The labeling specifies that a reduced initial dosage and careful monitoring are part of the established protocol, due to a potentially higher risk of certain side effects.

Q: Are there any long-term side effects reported for Keon?

A: The official safety profile states that the risk for serious adverse events may increase with the duration of use. Specifically, serious risks such as cardiovascular thrombotic events and gastrointestinal bleeding are described as being more likely if the medication is taken for a long period.

Q: How long does it typically take for Keon to start working?

A: For acute pain relief, clinical data summarized in official sources indicate that some patients reported the onset of pain relief within 30 minutes of taking a single oral dose. This data provides information on the typical time frame observed for the onset of effects in a clinical setting.

Q: Do studies suggest Keon is effective for conditions other than its main use?

A: Research studies have explored the effectiveness of the active ingredient in Keon for various conditions beyond its main uses. This includes conditions such as acute inflammation of the throat (pharyngitis) and different types of postoperative pain management.

Q: What is the risk of dependence or addiction with Keon?

A: The regulatory classification of the drug as a Schedule III controlled substance indicates an established potential for abuse and dependence. This classification is based on regulatory standards that recognize this potential.

Q: Is Keon linked to any potential vision changes?

A: Yes, the official regulatory label lists visual disturbance as an adverse reaction. This effect was reported to occur in a small but significant number of patients during clinical trials.

Q: What is the typical time frame for expected results from Keon treatment?

A: For pain relief, studies indicate that the analgesic effects of a single oral dose are reported to persist for up to 6 hours. This reported duration reflects how long the effects persisted in certain studies.

Q: Is Keon a new drug, or has it been around for a while?

A: Keon, which contains the active ingredient ketoprofen, has been used for many years. The drug was first created in 1967 and introduced for therapeutic use in certain countries starting in 1973, reflecting a long history in medicine.

Q: Can children or adolescents use Keon?

A: Official regulatory documents state that the safety and effectiveness of the drug have not been established in pediatric patients (children and adolescents). The statement is found in the official regulatory documentation.

Q: Do official documents mention any effects of Keon on mood?

A: Yes, the official label includes both mental/mood changes and depression among the reported adverse reactions. These are listed under the less common effects observed during clinical trials.

Q: What are the main research themes related to Keon's clinical trials?

A: Main research themes include exploring new delivery forms, combination therapies, and comparing its efficacy against other treatments for conditions like postoperative pain.

Q: Is it considered normal to experience [vague symptom] when first taking Keon?

A: The most commonly reported effects listed in official sources are the types of symptoms that some patients experience when starting treatment. These commonly reported effects include things like indigestion, headache, dizziness, and drowsiness.

Q: Is Keon used as a preventative medicine?

A: The general purpose of the drug, as described in official sources, is to provide symptomatic relief. It is used to relieve existing pain, inflammation, and fever, rather than being classified as an agent for prevention.

Q: What if a symptom that is not listed as an official side effect appears after taking Keon?

A: Regulatory patient information guides describe the process for reporting unlisted or unusual symptoms experienced while taking the medication. This ensures that all adverse events are properly reviewed by a healthcare professional.

Q: Why is Keon not recommended for people with a history of [specific serious condition]?

A: Official warnings cite an increased risk for specific serious conditions. This includes the potential for serious gastrointestinal bleeding or ulceration, as well as an increased risk of serious cardiovascular thrombotic events (such as heart attack or stroke).

How should Keon be stored and disposed of?

How to Store and Dispose of CREON (Pancrelipase)

Official regulatory documentation defines specific requirements for storing and handling this medicine to maintain its stability.

Storage Requirements

Condition Requirement
Temperature Store at room temperature, not exceeding 25 C (77 F).
Prohibited Do not refrigerate.
Packaging Keep the bottle tightly closed to protect the contents.

Stability and Handling

The medicine should be used within 6 months after the original bottle is first opened. Patients must not crush or chew the capsule contents; they should be swallowed immediately when mixed with acidic soft food. Specific governmental instructions for household disposal are not provided in the label; local drug take-back programs are generally recommended for unused medicines.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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