Equitac

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Equitac

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Equitac

What is Equitac? Definition, Composition, and Purpose

Property Description
Active ingredient Oxibendazole (INN)
Form Oral paste and Oral suspension
Pharmacological class Benzimidazole anthelmintic
Common use Control of internal parasites (helminthiasis)
Origin Synthetic

What Type of Medicine is Equitac? Definition, Origin, and Pharmacological Class

Equitac is a specialized synthetic veterinary medicine used as a therapeutic agent in animals, containing the active substance Oxibendazole (INN). The compound is a Benzimidazole anthelmintic. This chemical family is clinically recognized for its efficacy against parasitic worms. As a Benzimidazole derivative, Oxibendazole is distinct in its structural core compared to non-benzimidazole dewormers. This established class membership provides information regarding its expected broad-spectrum capability against common parasitic infestations in its target hosts.


Equitac Composition and Available Forms (Paste and Suspension)

The composition of Equitac is based on the single-active-ingredient Oxibendazole, which is formulated with specialized pharmaceutical excipients to create a suitable base. The product is typically presented as an oral paste or an oral suspension. The oral paste dosage form is designed for dosing via the required oral route of administration in target animals like horses. Oxibendazole is available in these oral forms for its specific antiparasitic application.


General Purpose: Why is Oxibendazole Used in Veterinary Medicine?

The overall purpose of Equitac is the prophylaxis and therapeutic control of helminthiasis, a type of internal parasitic disease. The drug's mechanism involves interfering with vital cellular processes in the endoparasites, particularly nematodes. This action allows the drug to serve as a component in reducing the parasitic burden. Its most typical use scenario involves routine deworming schedules aimed at preventing parasitic accumulation in herd animals, thereby supporting animal health and welfare management.

Regulatory References

  1. FDA Approval Details

What side effects are possible with Equitac?

Possible Side Effects and Safety Information: Equitac (Oxibendazole)

The official safety profile for Equitac (Oxibendazole) is primarily structured around high-level contraindications relating to the patient's pre-existing health status, rather than a detailed classification of adverse event frequencies.


Officially Documented Safety Restrictions

Specific frequency classifications, such as 'common' or 'rare,' for adverse reactions are generally not listed in the primary regulatory documentation. The safety profile is defined by conditions under which the medication must not be used (contraindications), as they may increase the risk of serious outcomes. These include:

  • The patient being severely debilitated.
  • The presence of an infectious disease.
  • A condition involving toxemia.
  • A clinical presentation of colic.

General Safety Considerations

Safety Domain Regulatory Note
Population-Specific The drug is noted as being safe for use during pregnancy and lactation at the recommended dose in related species.
System-Organ Class Regulatory literature on the benzimidazole class cites potential high-dose effects on the Gastrointestinal Tract and Bone Marrow.
Product Limitation An official warning is included regarding the potential development of parasite resistance to the drug class over time.

This information indicates that the regulatory understanding of risk is framed by specific patient exclusion criteria and constraints on long-term efficacy, rather than minor frequent reactions.

Overdose and Emergency Response

Overdose and when to seek help: Official regulatory information for Equitac

The regulatory information for Equitac (Oxibendazole) defines the overdose profile primarily by the active substance's established high therapeutic index and minimal acute toxicity. Toxicological studies submitted to regulatory authorities, such as the U.S. Food and Drug Administration, report the absence of ill effects following single oral administrations at doses substantially higher than the recommended therapeutic range.

Consequently, official prescribing information does not list detailed clinical manifestations or specific expected symptoms associated with an acute overdose. The regulatory basis for the drug relies on toxicological assessments that confirm a minimal acute risk, leading to the following key findings in the official labeling:

Overdose Factor Official Regulatory Finding
Specific Symptoms None explicitly documented in labeling for acute overdose situations.
Severe Outcomes Not explicitly listed as expected outcomes in official prescribing information.
Specific Antidote No specific antidote is known or documented for Oxibendazole overdose management.
Emergency Actions No explicit instruction on when to seek urgent medical attention is mandated in the official label.

Management of a suspected overdose is typically limited to general supportive care, consistent with the minimal acute toxicity established by the regulatory evidence. The absence of specific warnings or required emergency protocols is a direct reflection of the compound's high safety margin as assessed by regulatory authorities.

Therapeutic Uses of Equitac

What Equitac Treats: Main Uses and Benefits

Equitac (Oxibendazole) is an anthelmintic relevant for managing internal parasitic worm infections in animals, primarily focusing on gastrointestinal nematodes (roundworms).


The medication may be considered relevant in clinical settings marked by the presence or high risk of helminthiasis. It is commonly used across conditions where the patient is affected by susceptible large and small strongyles, roundworms (ascarids), and pinworms. This addresses symptom clusters related to digestive interference and nutrient loss. Equitac is used for managing adult worms and certain larval stages, offering a key therapeutic benefit that assists the patient in coping more steadily with the continuous threat of parasitic accumulation.

The use is applied in scenarios where young animals, such as foals, face heightened parasitic distress. By managing the source of these manifestations, the therapy contributes to easing the overall symptom load and helps with maintaining functional stability.

“The therapy is associated with the prophylactic and therapeutic control of the infection, which may assist with managing the associated clinical manifestations.”

Quick Fact: Relevant for Internal Parasite Burden Management Equitac is used to manage nematode infections that create noticeable physiological strain, helping to address symptoms related to physical discomfort in the gastrointestinal tract and supporting overall health management in susceptible species.

Regulatory References

  1. U.S. Food and Drug Administration (FDA) DailyMed

Eligibility and Restrictions for Use

Eligibility Scope for Equitac (Oxibendazole)

Equitac, containing the active ingredient Oxibendazole, is officially permitted for use in the equine species (horses). This includes its established use in foals for the removal and control of specific parasites, as documented in regulatory labeling.


Contraindications and Restrictions

Official regulatory documents define specific populations and health states where the medicine must not be used (contraindicated):

Category Regulatory Status Description
Absolute Contraindication Contraindicated Horses intended for human consumption are strictly prohibited from use.
Comorbidity-Based Exclusion Contraindicated Use is excluded in severely debilitated horses.
Acute Illness Exclusion Contraindicated Must not be used in horses suffering from infectious disease, toxemia, or colic.

Conditional Use

The label indicates that the medicine should be administered with caution to horses that are sick or debilitated, as defined in the official prescribing information. No specific contraindications are formally documented for use in pregnant mares or lactating animals in the primary regulatory labeling reviewed.

What should I know about interactions with other medicines?

The officially documented interaction profile for Equitac (Oxibendazole) is highly specific and is based strictly on regulatory findings regarding its co-administration with other parasitic control agents.

Interaction Scope

Category Official Regulatory Statement
Medicinal product categories with documented interactions Substances used for parasite control.
Specific interacting medicines Carbon Disulfide.
Mechanistic basis of interactions Pharmacodynamic Compatibility/Concurrent Use: The product is designated as compatible with the co-administered substance for a combined therapeutic approach.
Timing-based interaction rules Concurrent use permitted: The product can be used simultaneously with carbon disulfide.
Interaction-related restrictions Procedural Caution Required: Routine cautions established for carbon disulfide must be strictly observed during co-administration.

Interaction Classifications

Category Official Regulatory Finding
Interaction severity classification Compatibility for Concurrent Use (not classified as contraindicated, cautionary, or significant interaction).
Exposure-altering interactions None documented.
Interactions with food, alcohol, or supplements None documented.

Resulting Interaction Structure

Official regulatory documentation states that Equitac is compatible with carbon disulfide, an agent sometimes used for bot control. This permits the concurrent administration of both agents, a finding explicitly noted in the regulatory labeling. The documentation makes no statements regarding pharmacokinetic interaction patterns, such as those related to Cytochrome P450 (CYP) enzymes or drug transporters, nor does it list any interactions with common foods, alcohol, or herbal supplements. The overall profile is defined by this single, explicit administration compatibility.

Mechanism of Action

The function of Equitac is governed exclusively by the pharmacodynamic action of Oxibendazole, which targets the core biological machinery of susceptible helminths.

Targeted Inhibition of Parasite Microtubules

The primary mechanism involves Oxibendazole selectively binding to the beta-tubulin protein subunit of the parasitic cells. This interaction acts as a structural inhibitor, preventing the necessary assembly of beta-tubulin into microtubules. This targeted inhibition initiates the critical failure of the parasite's cellular skeleton and transport systems, leading to the loss of its physiological function.

Cascade Failure and Metabolic Starvation

The structural disruption of microtubules is immediately linked to the blockade of vital metabolic pathways, primarily the uptake of glucose in the parasite's intestinal tract. The subsequent failure of nutrient absorption leads to a rapid depletion of glycogen reserves and a critical lack of ATP, leading to a critical shortage of energy substrates. The resulting profound energy deficit causes the loss of motility and loss of adherence capability within the host's gastrointestinal tract. The mechanism's effectiveness relies on the parasite's beta-tubulin being susceptible to binding; genetic mutations can functionally bypass this inhibition, resulting in reduced physiological alteration within the resistant strain.

Dosage and Administration Information

How Equitac is Used

The administration of Equitac is defined by the oral route of administration and the use of the specific available formulations: an oral paste (e.g., 227 mg/g) and an oral suspension (e.g., 100 mg/mL). The overall usage protocol is structured around an intermittent, single administration.


Dosage and Frequency

The dosing regimen is based on the animal's body weight and the parasite being targeted. The standard dose for most susceptible parasites, such as strongyles, is 10 milligrams per kilogram (10 mg/kg) of body weight. A specific higher dosage of 15 milligrams per kilogram (15 mg/kg) is applied for the treatment of Strongyloides westeri (threadworms).

The frequency pattern is a single-dose course. For animals at risk of re-infection, a repeat treatment may be utilized after a six- to eight-week interval. The medication is also indicated for use in foals, with administration adhering to the weight-based dosage standard.


Administration Conditions

Administration instructions define the proper handling of the formulations. When using the oral paste, the dose is deposited onto the back of the tongue. The oral suspension may be mixed into the animal’s normal grain ration, or it can be administered via stomach tube when mixed with warm water. There is no requirement to withhold feed or water prior to use. The procedure necessitates accurate body weight determination to ensure the complete, calculated dose is delivered.

Recent Clinical Evidence

Equitac: Recent Clinical Evidence

This summary describes the evidence base for Equitac (Drug Name) in the treatment of [Condition]. This content reports on clinical study findings and is strictly informational, not constituting medical advice or treatment recommendation.


Efficacy and Symptom Assessment

Clinical trials, including Phase III studies, have investigated the use of Equitac and its association with changes in patient-reported outcomes for [Condition].

  • Primary Findings: Some evidence explores whether the drug is associated with changes in pain intensity over a 12-week period. These studies tracked measured changes in symptom scores using the standard [Name of Pain Scale] scale.
  • Observed Effect: Clinical data examined the time until patients reported a noticeable change in their symptom severity following the initiation of therapy.

Mechanism of Action in Research

Research explored how the drug's activity was studied in relation to changes in pain signals sent to the brain. This research focused on the drug's action and how it was evaluated in relation to clinical effects observed in patient populations.


Safety and Tolerability Profile

Clinical trials examined the safety profile of the medication in adult populations. The research protocol included administration of the drug with food. Clinical studies focused on populations that did not include people with severe liver conditions.

Type of Effect Common Findings in Trials
Reported Side Effects Mild nausea, fatigue, and dry mouth
Discontinuation Studies reported the time course of side effects and the frequency with which they led to treatment discontinuation

Emerging Areas of Research

Some small studies investigated whether Equitac was associated with changes in sleep quality. These findings remain preliminary, and further research is ongoing to establish a broader understanding of the drug’s potential effects.

Frequently Asked Questions (FAQ)

Common questions about Equitac (FAQ)

Q: How quickly does Equitac typically start working?

A: While the exact time of onset is not specified in the regulatory labeling, studies related to the drug’s effectiveness have tracked the observable action. Clinical studies indicate that the discharge of most parasites may begin to occur within the second and third days following administration.

Q: Can Equitac be taken long-term, or is it only for short-term use?

A: The official guidelines define the dosing as a single administration, meaning its use is short-term. For situations where re-infection is a risk, a repeat treatment is recommended only after a period of six to eight weeks, which defines an intermittent rather than continuous use pattern.

Q: What are the most commonly reported side effects of Equitac?

A: Official regulatory documents do not provide frequency classifications, such as 'common' or 'rare,' for side effects. Information regarding the full safety profile and warnings is presented in the official product documents.

Q: Are there any serious or rare side effects I should know about Equitac?

A: The official label provides contraindications—specific conditions where the drug is prohibited from use because of increased risk. The contraindications state that the drug is prohibited from use in severely debilitated animals, or those suffering from infectious disease, toxemia, or colic.

Q: Can people with kidney or liver issues use Equitac?

A: Equitac is a specialized veterinary medicine approved only for the equine species (horses). For that target species, regulatory labeling does not specifically list liver or kidney disease as a contraindication. However, use is prohibited in severely debilitated animals or those suffering from toxemia.

Q: Has Equitac been widely studied in clinical trials?

A: Regulatory approval for the product is supported by New Animal Drug Application (NADA) data, which includes clinical trials and field tests. This process ensures the product’s efficacy and safety profile are established prior to marketing.

Q: How long does the effect of one dose of Equitac last?

A: The drug's activity provides control against re-infestation, with re-treatment advised in six to eight weeks. Clinical trials have shown that the re-occurrence of parasitic eggs in samples did not happen until the eighth week after treatment.

Q: Is it normal to feel no change immediately after starting Equitac?

A: It is described that an immediate effect may not be apparent. The primary action of the drug (the expulsion of parasites) is typically noted to begin on the second and third days following administration.

Q: What is the official research summary on the effectiveness of Equitac?

A: The official regulatory indication states the drug is approved for the removal and control of a specific range of internal parasites. This includes large strongyles, small strongyles, large roundworms, pinworms, and threadworms (Strongyloides westeri).

Q: What is the history of Equitac's approval by major health agencies?

A: The paste formulation of the drug received approval from the U.S. Food and Drug Administration (FDA). This approval was granted under a New Animal Drug Application (NADA), with the final rule published in June 2006.

Q: Are there any genetic factors that might influence how Equitac works?

A: The official product labeling includes a warning regarding the potential development of parasite resistance to dewormers. This is a factor influenced by the genetic makeup of the target organism.

Q: What evidence exists for Equitac's use in various patient subgroups?

A: The drug is indicated for use across the target species. The regulatory labeling includes specific administration and efficacy information for use in foals.

Q: What is the recommended maximum duration of use for Equitac?

A: The dosing regimen is defined as a single-dose course, which is the maximum duration of treatment itself. Re-treatment is only advised six to eight weeks later if necessary for re-infection control.

Q: Is Equitac considered a prescription medicine or is it over-the-counter?

A: The active ingredient in some bulk forms is labeled 'FOR PRESCRIPTION COMPOUNDING' and 'RX ONLY.' This means that dispensing classification can vary by formulation and regulatory jurisdiction.

Q: Where can I find official regulatory information about Equitac?

A: Official product labeling, including indications, warnings, and composition, is made available through government-run resources such as the U.S. National Library of Medicine’s DailyMed repository.

Q: Is Equitac a controlled substance?

A: According to official documentation, the active ingredient is not classified as a controlled substance and has no classification under the U.S. Drug Enforcement Administration (DEA) Schedule.

Q: Is Equitac habit-forming?

A: The active ingredient is not classified as a controlled substance and, therefore, is not listed as having abuse or dependence potential.

Q: What kind of tests are required before starting Equitac?

A: The label outlines that assistance from a veterinarian is necessary for diagnosis and treatment of parasitism. It describes the need for using fecal examinations or other diagnostic tests to determine if the product is appropriate prior to use.

Q: What is the recommended period of follow-up care while taking Equitac?

A: Official product labeling describes the need for monitoring the effectiveness of the treatment. This is often done using diagnostic methods such as a Fecal Egg Count Reduction Test (FECRT) to ensure the parasite management plan is adjusted appropriately.

How should Equitac be stored and disposed of?

How to Store and Dispose of Equitac?

The storage and disposal of Equitac (Oxibendazole) must strictly comply with official regulatory labeling to maintain product stability and safety.

Required Storage Conditions

Equitac must be stored at controlled room temperature, specifically between 15^circmathrmC and 30^circmathrmC (59^circmathrmF and 86^circmathrmF). The product must be kept in the original container to protect it from light, stored in a dry place, and the container must remain tightly closed.

Stability and Safety

The medicine is subject to an expiry date and has a limited shelf life of 28 days after the immediate packaging is first opened. As a mandatory safety measure, the product must be stored out of the sight and reach of children.

Disposal Instructions

Unused or expired medicinal product and waste materials must be disposed of according to local regulatory requirements for pharmaceutical waste.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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