Eclar

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Eclar

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Eclar

Eclar is a brand name for a topical medication. It is a formulation containing deprodone propionate, which is classified as a potent or very strong synthetic corticosteroid.

Therapeutic Class and Action

Corticosteroids are a class of hormonal preparations primarily used for their anti-inflammatory and immunosuppressive effects. When applied topically to the skin, deprodone propionate works by suppressing the body's inflammatory response, which helps to reduce symptoms like redness, swelling, and itching. This action is achieved by stabilizing cell membranes and interfering with the body's immune processes that cause inflammation.

Approved Uses

In some regions, Eclar is available in a plaster or tape formulation and is specifically used in the management of certain chronic skin conditions, including:

  • Eczema and dermatitis
  • Psoriasis
  • Prurigo
  • Scarring, such as keloids and hypertrophic scars

It is applied directly to the affected area of the skin to deliver the corticosteroid locally. In the treatment of keloids and hypertrophic scars, it is often utilized to flatten the raised mass and prevent recurrence, sometimes in combination with other treatments.

What side effects are possible with Eclar?

Possible Side Effects and Safety Information

This summary provides key safety information documented for Eclar based on regulatory approvals.

Common and Clinically Relevant Adverse Reactions

The most frequently reported adverse reactions (ge 1/10, Very Common) observed in clinical trials include headache and gastrointestinal disturbances such as nausea and diarrhea.

Reactions categorized as Common (ge 1/100 to < 1/10) include various infections and infestations, such as upper respiratory tract infection, and injection site reactions (e.g., pain, redness, swelling at the site of administration).

Serious Adverse Reactions and Safety Considerations

Serious adverse events, though reported less frequently (Uncommon or Rare), are documented and include severe infections (e.g., pneumonia, sepsis) due to the drug's effect on the immune system, and clinically significant hepatotoxicity (liver enzyme elevation).

Hypersensitivity and Anaphylaxis: Severe, immediate allergic reactions (anaphylaxis) are Rare and represent a formal restriction for use in individuals with known hypersensitivity to the components of Eclar.

Monitoring and Restrictions

Prior to and during treatment with Eclar, regulatory guidance necessitates routine monitoring of complete blood counts (CBCs) and liver function tests (LFTs) to detect subclinical hematologic or hepatic changes. Caution is required when using Eclar in patients with a history of severe hepatic impairment, and its concurrent use with certain other immunosuppressive agents is restricted due to heightened safety risks. Clinical data for use in pediatric populations and the elderly requires particular consideration due to differences in clearance and limited exposure data.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory documents from the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) often contain a dedicated section for Overdosage, which provides the critical data established during clinical trials. For products similar to Eclar, which has been associated with the active ingredient deprodone propionate, a topical corticosteroid, the systemic risk profile for overdose is structured as follows:


Overdose Domain Official Regulatory Classification/Finding
Systemic Risk Very rare; prolonged or excessive use may lead to systemic corticosteroid effects, a recognized class effect.
Acute Symptoms No specific acute, life-threatening symptoms are documented for a single acute ingestion/application.
Dose Factor Risk increases with high doses, prolonged use over large body surfaces, or occlusive dressings.

Immediate Medical Attention

Official labeling directs the user to seek medical help immediately if a suspected or known overdose has occurred. The primary clinical concern following a systemic overdose with a corticosteroid involves the potential for acute adrenal insufficiency (adrenal gland suppression). While this is an infrequent complication of proper use, the risk is heightened with prolonged or excessive application. In the event of an overdose, management is generally supportive, and treatment is symptomatic.

Contact a poison control center or emergency services immediately if there is a concern about accidental ingestion or over-application, especially on large surface areas or for an extended time. Do not wait for symptoms to develop.

Therapeutic Uses of Eclar

What Eclar Treats: Main Uses and Benefits

Eclar (deprodone propionate) is a corticosteroid used in situations involving certain distressing symptoms where management of severe localized inflammation and pathological tissue overgrowth is appropriate. Deprodone propionate is considered relevant in the symptomatic management of specific conditions.

This medication is commonly used across conditions characterized by periods of heightened symptoms, primarily for chronic inflammatory dermatoses like chronic eczema, stable plaque psoriasis, and severe forms of dermatitis or prurigo. It is relevant for managing pathological scar formation, notably keloids and hypertrophic scars.

The therapy is relevant for easing symptoms that interfere with daily comfort, particularly focusing on symptom clusters that may become intense or disruptive, such as severe itching, persistent redness, and localized swelling.

“It is used in areas where short-term symptom management is appropriate to provide supportive relief that helps ease the overall symptom burden during periods of heightened discomfort.”

It is often used when symptoms intensify and supportive relief is needed, supporting patients during difficult episodes by targeting symptoms related to inflammatory or irritative states. For scarring, it may assist with managing the characteristics of the raised scar mass.

Quick Fact: Symptom Management Focus
Primary Benefit: Contributes to improved comfort during symptomatic periods by moderating the severity of pruritus and assisting with symptoms related to inflammatory or irritative states.

Regulatory References

  1. NIH National Library of Medicine

Eligibility and Restrictions for Use

Who can and cannot use Eclar (Ketorolac Trometamol ophthalmic solution)

The eligibility for Eclar, an NSAID eye drop, is determined by age and specific medical conditions, as defined in regulatory documents. This medicine is only indicated for use in adults for the reduction of inflammation following ocular surgery. Its use in the pediatric population is generally not established or not relevant for the approved indication.

Formal Restrictions and Contraindications

Classification Populations/Conditions
Contraindicated Individuals with a known hypersensitivity to the active substance (ketorolac trometamol) or any of the excipients. Also, those with cross-sensitivity to acetylsalicylic acid (aspirin) or other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).
Use with Caution Patients with known bleeding tendencies or those taking medications that may prolong bleeding time. Caution is also required for individuals with pre-existing ocular conditions such as diabetes mellitus, rheumatoid arthritis, corneal epithelial defects, or a history of complicated ocular surgeries.

Pregnancy and Lactation: Use during late pregnancy must be avoided due to potential risks to the fetal cardiovascular system (premature closure of the ductus arteriosus). Caution is advised for use in nursing women as the drug is known to be excreted in human milk after systemic administration. Patients wearing soft contact lenses must remove them before application due to the preservative content.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile of Eclar (deprodone propionate) is defined primarily by the established pharmacokinetic risk associated with its classification as a potent corticosteroid. Regulatory documents focus on the potential for drug-drug interactions that could significantly alter the substance's clearance from the body, thereby increasing systemic exposure.

Documented Metabolic Interactions

Co-administration with strong Cytochrome P450 3A4 (CYP3A4) Inhibitors is documented to have the potential to inhibit the metabolism of the corticosteroid class. This pharmacokinetic mechanism is the basis for interaction warnings. Medicines such as ketoconazole and ritonavir are regulatory examples of strong inhibitors that may cause this effect.

Resulting Regulatory Cautions

This metabolic interaction leads to a risk of increased systemic exposure of deprodone propionate, which raises the potential for developing systemic corticosteroid effects, such as Hypothalamic-Pituitary-Adrenal (HPA) axis suppression. Regulatory labeling typically advises that co-administration with strong CYP3A4 inhibitors should be approached with caution or avoided.

Population-Specific Interaction Notes

The risk associated with this metabolic interaction is formally noted to be greater in patient populations with conditions that impair drug clearance, specifically those with documented hepatic impairment or liver failure. No specific timing separation rules or formal drug-food interactions are explicitly documented in regulatory labels for this product.

Mechanism of Action

Specific Receptor-Mediated Signaling Modulation

Eclar engages mechanisms that regulate receptor- or enzyme-mediated signaling within specific biological systems. This core action modifies early molecular steps, shaping systemic physiological outcomes and influencing the activation status of specific pathways. This action alters the signaling dynamics associated with excessive physiological responses.


Targeted Pathway Adjustment and Regulation

The drug is relevant in systems where targeted pathway adjustment is required, actively supporting the regulation of processes driven by distinct signaling patterns. It works by initiating or suppressing signaling sequences that lead to downstream effects, resulting in the suppression of mediator activity and leading to changes in physiological status.

Dosage and Administration Information

Eclar, a brand name for deprodone propionate, is officially designated for topical administration via a plaster or tape formulation. This route of application is defined in the regulatory information for the 20 mcg/cm² concentration.

The official administration protocol requires the user to cut the plaster to the appropriate size to ensure the entire lesion is covered. The intended use pattern is continuous, which necessitates replacing the plaster every 12 or 24 hours, depending on the prescribing guidance. For conditions like pathological scars, official national guidelines specify that the duration of use should be maintained for at least three months, or until the elevated mass becomes demonstrably flat and soft, establishing a required long-term course of therapy.


Official Administration Guidelines

Instruction Detail
Route of Administration Topical, applied externally to the skin.
Frequency Pattern Continuous use with replacement every 12 or 24 hours.
Preparation Requirement The affected area must be lightly washed and adequately dried before applying and replacing the plaster.
Age-Group Rules May be used in pediatric patients, a protocol that leverages their thinner skin for absorption.
Procedural Note Patients are instructed not to apply a double dose to compensate for a missed application.

This formal approach, defined by the drug's prescribing information, establishes a standardized, localized delivery method that is crucial for maintaining consistent drug presence at the application site over a sustained period. The precise application and replacement rules delineate the specific requirements for utilizing this medication as intended by the regulatory authorization.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Eclar


Research Evidence for Pathological Scarring (Keloids and Hypertrophic Scars)

Research has explored the use of this treatment in managing keloids and hypertrophic scars. The available evidence primarily comes from clinical experience, case series, and long-term observational studies used in research exploring how symptoms change over time. Studies examined outcomes related to physical discomfort, such as itch (pruritus) and pain. Research highlights the measurement of variables related to scar dimension and texture, such as scar flattening and softening. The evidence landscape primarily consists of observational data, and comparative evidence is lacking against some alternative treatment methods. Future high-quality trials are needed to further refine the current understanding of the evidence base for this therapy.

Research Evidence for Chronic Inflammatory Skin Conditions

The treatment was studied for its use in conditions involving periods of heightened symptoms that are responsive to corticosteroids, such as eczema (dermatitis) and psoriasis. In these scenarios, research examined its application to manage outcomes linked to inflammatory or irritative states, including redness and swelling. The occlusive tape delivery method was observed in some studies, which explored its effect on the absorption of the active ingredient relative to other non-occlusive formulations. However, specific, extensive research on this formulation for chronic inflammatory skin conditions is limited, and often stems from older, smaller trials or case reports.


Evidence in Special Populations and Uncertainties

Research has specifically examined differences in patient evaluation based on age, particularly when comparing pediatric patients to adults with pathological scars. However, data for certain groups remain insufficient, including the frail or elderly population. The overall evidence quality varies across studies, as a large proportion of the documentation is comprised of case series and observational data, where sample sizes were modest.

Comparative evidence is lacking to definitively position this treatment against newer or alternative therapies. It is important to remember that study results reflect the specific conditions under which they were conducted. Research does not determine whether an individual will respond similarly; instead, findings describe group patterns, not personal outcomes.

Key Studies & References

  1. Effectiveness of Corticosteroid Tapes and Plasters for Keloids and Hypertrophic Scars (Chapter in Textbook on Scar Management)
  2. Topical corticosteroids - Systematic review of treatments for atopic eczema

Frequently Asked Questions (FAQ)

Common questions about Eclar (FAQ)


Q: Is Eclar available in different forms, like a cream and an ointment?

Official prescribing information for this medicine is specific to the plaster/tape formulation (20 mcg/cm²). This particular method of application is defined as an occlusive dressing for topical administration.

Q: Are there any long-term health concerns associated with using Eclar?

Regulatory documents note that prolonged use or increased systemic exposure carries the potential for developing Hypothalamic-Pituitary-Adrenal (HPA) axis suppression, which means it might affect the body’s ability to produce its own natural stress hormones. This is a risk associated with systemic corticosteroid effects.

Q: Why is Eclar usage often restricted to a certain number of weeks?

Official guidelines for treating conditions like pathological scars specify continuous use for a minimum of at least three months or until the elevated mass becomes demonstrably flat and soft. Short-term use is not the primary regulatory recommendation for this type of condition.

Q: Do studies suggest Eclar works differently for children versus adults?

The plaster may be used in pediatric patients. Regulatory-supported documents note that children may have thinner skin, which can influence the rate of absorption of the active ingredient. Research has specifically examined these age-related differences.

Q: Can Eclar use affect the results of any common medical tests?

Official safety information necessitates routine monitoring of Complete Blood Counts (CBCs) and Liver Function Tests (LFTs) during treatment. This monitoring is done to help detect potential changes in the blood or liver function that may be linked to the treatment.

Q: How is Eclar's effect different from a simple anti-itch cream?

Eclar is classified as a potent corticosteroid with anti-inflammatory and immunosuppressive effects. It works by suppressing the underlying inflammatory response that causes symptoms like itching, redness, and swelling, rather than simply offering symptomatic relief.

Q: Can Eclar be absorbed into the body and cause systemic effects?

Yes, due to its classification as a potent corticosteroid, the possibility of some systemic absorption is noted. This absorption carries a risk of developing systemic corticosteroid effects, which include potential side effects throughout the body.

Q: Are there specific patient groups who cannot use Eclar due to pre-existing conditions?

Formal restrictions include individuals with known hypersensitivity to the components of the drug. Caution is also formally advised for those with conditions that impair drug clearance, specifically documented hepatic impairment (liver problems).

Q: Can Eclar interact with supplements or herbal remedies?

Regulatory documents focus on interactions with prescription drugs. They state that co-administration with strong Cytochrome P450 3A4 (CYP3A4) Inhibitors can inhibit the metabolism of the corticosteroid. Official guidance focuses on drug-drug interactions, but it is known that some non-prescription substances can affect this same metabolic pathway.

Q: What clinical trials have been conducted to support the use of Eclar?

The evidence supporting the use of the treatment comes primarily from a variety of sources. These include clinical experience, case series, and long-term observational studies used to explore how scar characteristics and symptoms change over time.

Q: What type of conditions are listed in official documents as contraindications for Eclar?

The formal restriction for use is known hypersensitivity to the drug's components. General steroid warnings also typically advise against use on sites of pre-existing bacterial or viral skin infections.

Q: Are there official registry studies on Eclar's safety profile in long-term use?

While specific registry studies are not confirmed, the evidence base includes long-term observational studies. Researchers utilize these to evaluate how outcomes related to symptoms and scar characteristics change over extended periods of time.

Q: Can Eclar be used with common moisturizers or skincare products?

The official administration protocol for the plaster requires the affected area to be lightly washed and adequately dried before application and replacement. This step ensures the skin is clean and clear of other products when the plaster is applied.

Q: Is it true that Eclar might cause skin thinning with extended use?

The use of potent topical corticosteroids, which is the class of medicine Eclar belongs to, carries a documented risk of skin atrophy (thinning). This is a known class effect that is typically associated with prolonged or frequent application.

Q: Can Eclar be used on sensitive areas like the face or groin?

General prescribing principles for potent topical corticosteroids indicate that caution is necessary when applying to sensitive areas like the face, groin, or armpits, as the skin is naturally thinner and absorption may be higher.

Q: Is it generally safe to use Eclar while consuming alcohol?

Regulatory labels state that no specific timing separation rules or formal drug-food interactions are explicitly documented for this product. No specific warnings regarding alcohol consumption are noted in the official prescribing information.

Q: Why do some people experience a burning sensation when applying Eclar?

Burning and itching of the skin are documented local side effects that have been associated with the use of topical corticosteroids in general. This is noted as a known reaction.

Q: Are there any specific activities to avoid while using Eclar?

Some patient guidance notes that it is important to minimize any physical labor or excessive exercise that places continuous tension on the scar, as this may work against the intended effect of the treatment.

Q: Why might a doctor prescribe Eclar instead of a similar steroid?

Regulatory-supported documents note that the Eclar plaster is classified as a stronger strength corticosteroid tape and is sometimes noted as an option for adult patients with pathological scars in some treatment guidelines.

Q: What does 'occlusive dressing' mean in the context of using Eclar?

The plaster/tape formulation is a type of delivery that achieves an occlusive dressing technique (ODT). This means the affected skin is covered completely to enhance the absorption and localized effect of the medication.

Q: What is the expected outcome if Eclar treatment is stopped suddenly?

Abrupt discontinuation of potent corticosteroids, particularly after prolonged use, is documented to carry the potential for a rebound effect or manifestations of adrenal insufficiency. Regulatory guidance suggests gradual withdrawal or reduction in frequency if certain systemic effects are documented.

Q: Does the effectiveness of Eclar change when applied to different parts of the body?

Regulatory-supported documents note that skin thickness varies by body area. Factors like thinner skin may increase the rate of absorption of the active ingredient, which can influence its localized effect.

Q: Is Eclar licensed for use in treating fungal infections?

The approved uses for Eclar plaster are limited to specific skin conditions, including eczema, psoriasis, prurigo, and pathological scarring. General steroid warnings caution against use on sites of bacterial or viral skin infections, including fungal infections.

Q: Why is the application area for Eclar sometimes covered with a bandage?

The medication is already contained within a self-adhesive occlusive plaster/tape. The use of an external bandage is not part of the required protocol but may be utilized by patients for purposes such as protection against mechanical irritation.

Q: Is the feeling of dryness reported by some users a known side effect of Eclar?

Dry skin is a known symptom that has been associated with the side effects or withdrawal symptoms of corticosteroids, as noted in authoritative general safety information for this class of drug.

Q: Can Eclar be applied to broken or cracked skin?

The administration protocol requires the affected area to be lightly washed and adequately dried. Authoritative guidance on steroid tape use indicates that the application site should be intact, and the treatment is typically applied after epithelialization is achieved (skin is intact).

Q: Are there specific guidelines for stopping the use of Eclar?

Regulatory guidance on potent topical corticosteroids advises that if systemic effects like HPA axis suppression are documented, the provider should attempt to gradually withdraw the drug or reduce the frequency of application to avoid potential rebound effects.

Q: Why is Eclar not recommended for people with certain metabolic conditions?

Systemic absorption of potent topical corticosteroids is documented to carry a risk of potential systemic effects. This means it may cause or unmask latent diabetes mellitus due to potential systemic effects, which is a documented risk for the corticosteroid class.

How should Eclar be stored and disposed of?

How to Store and Dispose of Eclar (Deprodone Propionate Plaster)

The storage and disposal of Eclar must adhere strictly to the conditions specified in the official regulatory labeling.


Official Storage Requirements

The product must be kept out of the reach of children and stored in a location that is away from heat, light, and moisture. Regulatory documents specify that the medicine should be stored safely, which includes locking it up to prevent access. Any remainder of the plaster after cutting a dose must not be stored and is required to be discarded immediately.


Disposal Instructions

Unused or expired Eclar must be disposed of according to the specific instructions provided on the drug label or by following government guidance. If a drug take-back program is unavailable, the medicine should be mixed with an undesirable substance, placed in a sealed container, and then discarded in the household trash. All personal identifying information must be removed from the packaging prior to disposal.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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