Dutrav

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Dutrav

Method of action: Antiglaucomatous

Treatment option: Hypertension, Glaucoma

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Dutrav

Property Description
Active ingredient Travoprost, Timolol maleate
Form Ophthalmic solution (Eye drops)
Pharmacological class Prostaglandin Analogue + Beta-Blocker
Primary purpose Reduction of elevated Intraocular Pressure (IOP)
Type Fixed-dose combination product, Prescription-only (Rx)

What Type of Medicine is Dutrav?

Dutrav is defined as an ophthalmic solution administered as eye drops, characterized as a fixed-dose combination product containing two distinct active substances. It is typically supplied as a sterile, prescription-only (Rx) medication. This combination places it in the class of antiglaucoma agents, specifically merging a prostaglandin analogue (Travoprost) with a non-selective beta-adrenoceptor antagonist or beta-blocker (Timolol). Combining agents with distinct mechanisms is a recognized strategy for therapeutic approach in this field.


Understanding the Dual Composition and Purpose

The formulation’s effectiveness relies on its two principal active ingredients: Travoprost and Timolol maleate. Travoprost is an isopropyl ester prodrug and Timolol is a synthetic beta-blocker. This specific dual composition is recognized for providing a significant and sustained reduction of intraocular pressure (IOP). The general purpose is to provide a comprehensive management strategy for IOP, utilizing the Travoprost component to increase fluid drainage and the Timolol component to decrease fluid production. This fixed-combination strategy is utilized when patients require a greater pressure-lowering effect than achieved with a single agent alone.

Regulatory References

  1. Travoprost Ophthalmic: MedlinePlus Drug Information

What side effects are possible with Dutrav?

Possible Side Effects and Safety Information for Dutrav

The safety profile of Dutrav (Travoprost/Timolol) is structured around the known effects of its two active components: the prostaglandin analogue and the beta-blocker.

Adverse Reaction Scope

The most common adverse reaction (Very Common: ge 1 in 10 patients) is ocular hyperaemia (eye redness). Other common ocular effects include eye irritation, dry eye, eye pain, and blurred vision.

Serious and Clinically Significant Adverse Reactions

The beta-blocker component (Timolol) can be absorbed systemically and may cause serious reactions similar to those seen with oral beta-blockers, including the potential for severe respiratory reactions (e.g., bronchospasm, which may be fatal in patients with a history of asthma or severe chronic obstructive pulmonary disease) and cardiac reactions (e.g., severe bradycardia, heart failure, and cardiogenic shock). Ocular use has also been associated with macular oedema and potentially severe anaphylactic reactions in susceptible individuals.

Ocular Risks and Changes

Travoprost may cause gradual, long-term, and potentially permanent changes to the treated eye, including iris color change (increased brown pigmentation, leading to heterochromia if used unilaterally) and periorbital and/or eyelid skin darkening. It may also cause noticeable, gradual changes to the eyelashes, such as increased length, thickness, and number.

Safety Restrictions and Contraindications

Due to the systemic activity of the beta-blocker, Dutrav is contraindicated in patients with a history of bronchial asthma, severe chronic obstructive pulmonary disease, certain heart conditions (e.g., sinus bradycardia, overt cardiac failure, cardiogenic shock), and severe allergic rhinitis. Its use is not recommended in children under 18 years of age due to unestablished safety and efficacy, and it must not be used during pregnancy.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information regarding Dutrav (Travoprost/Timolol) overdose centers on the potential systemic effects of the Timolol component and mandates specific emergency actions.

Documented Overdose Manifestations

Topical overdose from excessive drops may result in local ocular hyperaemia (eye redness), eye irritation, and eye pain. More serious manifestations stem from the systemic absorption of the beta-blocker component, Timolol, following either excessive topical use or accidental oral ingestion.

Systemic manifestations officially documented include signs of beta-blockade such as bradycardia (slow heart rate), hypotension (low blood pressure), dizziness, and bronchospasm.

Serious Outcomes and Emergency Action

Regulatory sources cite the potential for severe, life-threatening cardiovascular consequences in systemic overdose, including cardiac failure, cardiogenic shock, cardiac arrest, and respiratory failure. Patients with pre-existing conditions like asthma or cardiac failure are noted to be particularly susceptible to severe outcomes.

Immediate medical attention is required for accidental ingestion or if systemic symptoms such as fainting, severe dizziness, or difficulty breathing occur. In these situations, contact a healthcare practitioner, hospital emergency department, or poison control center. For simple over-application to the eye, rinsing the eye immediately with warm tap water is advised by regulators.

Management of systemic overdose is symptomatic and supportive, addressing the cardiovascular and respiratory depression. Regulatory information states that no specific antidote is known for Timolol overdosage.

Therapeutic Uses of Dutrav

Dutrav: Main Uses and Clinical Benefits

Quick Facts

  • Therapeutic Domain: Helps manage elevated pressure within the eye.
  • Primary Use: Supports the reduction of high pressure associated with open-angle glaucoma.
  • Secondary Use: Indicated for patients managing ocular hypertension (high pressure in the eye).
  • Patient Group: Used in adult patients who have not experienced a sufficient therapeutic response to initial, single-agent therapy, such as topical beta-blockers or prostaglandin analogues.

Dutrav is a prescription ophthalmic solution approved for the management of elevated intraocular pressure (IOP). Maintaining IOP within a target range is an important component of managing specific eye conditions.

The medication is primarily indicated for adult patients who have open-angle glaucoma or ocular hypertension. These conditions are characterized by pressure in the eye that is above the typical range. When single medications, such as a topical beta-blocker or a prostaglandin analogue, do not provide the necessary reduction in pressure, Dutrav may be professionally recommended as a fixed-combination therapy to assist in achieving the clinical goal.

By helping to reduce and sustain a lower intraocular pressure, the treatment aims to provide clinical benefit in preserving visual function. Dutrav contains two components that work in a complementary manner to facilitate the reduction of pressure inside the eye.

Eligibility and Restrictions for Use

Who Can and Cannot Use Dutrav?

This information details the officially documented population eligibility rules for the use of Dutrav, based strictly on government regulatory documents.

Contraindicated Populations

Use of Dutrav is contraindicated and must be avoided in patients with certain pre-existing conditions, primarily due to the beta-blocker (Timolol) component. This includes individuals with bronchial asthma, a history of asthma, or severe Chronic Obstructive Pulmonary Disease (COPD). Use is also contraindicated in those with specific severe cardiac conditions such as sinus bradycardia, overt cardiac failure, cardiogenic shock, or second- and third-degree atrioventricular (AV) block. Patients with hypersensitivity to any of the active substances are prohibited from use.


Age and Physiological Restrictions

Population Group Regulatory Status
Pediatric Patients (Under 18) Not Recommended. Safety and efficacy have not been established in this age group.
Pregnant Women Contraindicated. Women of child-bearing potential must use adequate contraception.
Breastfeeding Women Not Recommended.
Adults (including Geriatric) Approved. Safety is established for use in the adult and elderly population.

Conditional Use and Comorbidities

Use requires caution in patients with certain conditions, including diabetes mellitus (due to potential masking of hypoglycemia symptoms) or severe peripheral circulatory disturbances. Patients with renal or hepatic impairment are generally eligible, but caution is advised in alignment with official labeling.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation structures the interaction profile of Dutrav based on the systemic absorption and known effects of its Timolol component, a beta-blocker.

Documented Pharmacodynamic and Metabolic Interactions

Co-administration with certain medicinal products is documented to result in additive effects or altered exposure:

  • Oral Cardiovascular Agents: Concomitant use with agents such as oral calcium channel blockers, antiarrhythmics, digitalis glycosides, or systemic beta-blockers may produce additive pharmacodynamic effects, including a potential for hypotension and/or marked bradycardia, as specified in regulatory labels.
  • Metabolic Inhibitors: Co-administration with strong CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine) is documented to lead to potentiated systemic beta-blockade. This is an official pharmacokinetic interaction pattern resulting from reduced Timolol clearance and increased exposure.
  • Antidiabetic Products: The Timolol component may increase the hypoglycaemic effect of antidiabetic medicines and may mask the physical signs and symptoms of acute hypoglycemia.

Administration Restrictions

Regulatory authorities impose specific restrictions on co-administration:

  • The use of two topical beta-adrenergic blocking agents in the eye is not recommended due to the potential for additive systemic effects and a possible loss of therapeutic efficacy.
  • If other topical ophthalmic products are used, they must be administered at least 5 minutes apart from Dutrav.

Mechanism of Action

How Dutrav Works: Mechanism of Action

Dutrav functions through a complementary dual pharmacodynamic mechanism that modulates the two principal regulators of ocular fluid pressure: production and drainage.

One mechanism is driven by Travoprost, which, upon activation to its free acid form, acts as an agonist of the Prostaglandin F (FP) receptor in the ciliary muscle. This receptor activation initiates a molecular cascade that includes the upregulation of Matrix Metalloproteinases (MMPs), which facilitate the enzymatic remodeling of the extracellular matrix (ECM) components. This process structurally reduces hydraulic resistance in the uveoscleral outflow pathway, thereby modulating the rate of aqueous humor egress from the eye.

The second mechanism is mediated by Timolol, which functions as a non-selective antagonist by competitively blocking beta1 and beta2 adrenergic receptors in the ciliary body epithelium. This blockade suppresses sympathetic-mediated signaling, leading to a reduction in the intracellular concentration of cyclic adenosine monophosphate (cAMP). This limits the active ion transport necessary for secretion, resulting in a marked decrease in the formation and production of aqueous humor.

This simultaneous modulation of both inflow and outflow pathways results in a substantial physiological consequence of modified intraocular pressure through physical and cellular regulation.

Dosage and Administration Information

How to Use Dutrav: Official Administration Guidelines

Dutrav (a fixed-dose combination of Travoprost and Timolol) is administered as an ophthalmic solution for topical application.

Administration Scope

Instruction Description
Route of administration Topical Ocular use only (directly into the eye).
Dosing schedule One drop in the conjunctival sac of the affected eye(s).
Frequency and maximum dose Once daily, administered at the same time each day (morning or evening). The dose must not exceed one drop daily.
Missed-dose rule If a dose is missed, treatment should be continued with the next planned dose at the regular time; a double dose should not be applied.

Procedural and Population Rules

Proper use dictates that the medicine should be administered into the conjunctival sac, with care taken to avoid contact between the dropper tip and the eye or any surrounding surfaces to prevent contamination. If other topical eye medications are required, they must be administered at least five minutes apart to ensure proper absorption of each drug.

Soft contact lenses must be removed prior to application and may only be reinserted 15 minutes following instillation. Regarding patient groups, the dosage is the same for older adults as for other adults. The medicine is not recommended for pediatric patients (under 18 years) due to insufficient established data.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Dutrav

The body of research for the travoprost/timolol fixed combination (Dutrav) primarily consists of clinical evaluations required by regulators in the clinical contexts studied. These studies was studied for measured outcomes related to the pressure inside the eye, known as Intraocular Pressure (IOP).


Evidence for Use in Elevated Intraocular Pressure (IOP)

The core evidence comes from Randomized Controlled Trials (RCTs). These trials research examined measured outcomes when the fixed combination was evaluated in comparison to other therapies, such as using its components—travoprost or timolol—alone. These studies was observed in individuals who have Open-Angle Glaucoma (OAG) or Ocular Hypertension (OH), conditions associated with high IOP.

In these formal trials, the main outcome was evaluated in the change in Intraocular Pressure (IOP) measured from the start of the study. Researchers monitored whether the fixed combination was associated with measurements of IOP change that were similar to those observed when administering the two components separately (unfixed combination). When comparing the fixed combination against its individual component drops, studies reported data regarding the IOP measurements observed in the respective groups.


Long-Term Study Landscape and Durability of Follow-up

Key efficacy studies cover short-term follow-up periods, often ranging from 4 weeks to 3 months, with extended-duration research tracking outcomes for up to 2 years. Research, where the follow-up durations were limited, research describes the stability of the measured IOP changes during the observed study period. Currently, long-term outcomes are not fully established regarding the use of the fixed combination over multi-year periods. Data for long-term outcomes (beyond 2 years) was observed in some studies but remains a limited area of research.


Research Gaps and Areas of Uncertainty

While the fixed combination was studied for its measured outcomes on the IOP biomarker, there are areas where the evidence base was less characterized. There is limited information for long-term outcomes concerning functional endpoints, such as visual field damage or patient-reported perceived discomfort. Some of the studies examining specific subgroups had modest sample sizes, which means that subgroup findings are uncertain. Comparative evidence is limited for certain rare types of glaucoma. Results apply only to the populations studied.

Frequently Asked Questions (FAQ)

Common questions about Dutrav (FAQ)


Q: What should I do if I miss a scheduled dose of Dutrav?

A: If a dose of this ophthalmic solution is missed, official product information advises continuing the treatment with the next planned dose at the regular time. Official product information describes that a double dose is not applied to compensate for the missed one.


Q: Can Dutrav affect my ability to drive or operate machinery?

A: Regulatory information indicates that the medicine may cause temporary blurred vision or drowsiness in some people immediately after application. Official documents state that the patient should wait until these effects subside before driving or using machinery.


Q: What is the difference between Dutrav and other similar medications?

A: Official documents describe Dutrav as a fixed-dose combination product containing two active substances with complementary mechanisms of action. One ingredient increases fluid drainage, while the other decreases fluid production. Clinical studies compared the combined effect to using either component alone and reported additional pressure reduction measurements.


Q: Is Dutrav a controlled substance?

A: Regulatory sources classify Dutrav as a Prescription-only medicine (Rx) that requires a valid prescription from a licensed healthcare provider. However, the active ingredients are generally not classified under the US Controlled Substances Act (Schedules I-V).


Q: What happens if I accidentally take two doses close together?

A: In case of accidental administration of too many drops, regulatory information advises immediately washing the eye with warm tap water. Symptoms may include the eyes becoming red and irritated. Official information states that a healthcare professional, hospital emergency department, or regional poison control center is contacted, even if symptoms are absent.


Q: What is the typical timeframe for seeing the full benefit of Dutrav?

A: According to official product information, a reduction in the pressure inside the eye is observed within approximately 2 hours after administration. The maximum measured effect is typically reached after 12 hours.


Q: Is Dutrav a type of painkiller?

A: Regulatory documents classify Dutrav as an Antiglaucoma preparation, which is a class of medicine used for eye conditions. Its primary purpose is the reduction of elevated intraocular pressure (IOP). Regulatory documents do not classify it as a painkiller (analgesic).


Q: Is Dutrav known to cause weight gain?

A: Regulatory safety documents list the known and common adverse reactions associated with this medicine. Weight gain or significant weight change is not typically listed among the common or very common side effects in the official product information.


Q: Are there any common foods or drinks that should be avoided while taking Dutrav?

A: Interaction sections in regulatory documents primarily focus on co-administered medicinal products. Specific common foods or non-alcoholic drinks to be avoided are not typically listed in the official product information.


Q: How long do most people need to take Dutrav?

A: Dutrav is indicated for conditions like Open-Angle Glaucoma and Ocular Hypertension. These are generally understood in a regulatory context as chronic conditions requiring long-term management, which is determined by a healthcare provider.


Q: Is it normal to feel tired after starting Dutrav?

A: Fatigue (tiredness) is listed among the side effects observed in other areas of the body, according to regulatory consumer information. If this is experienced, it is consistent with effects described in official documents.


Q: Is Dutrav safe to use during pregnancy or while breastfeeding?

A: Use of Dutrav is contraindicated (avoided) during pregnancy, and women of child-bearing potential are typically advised to use adequate contraception as a condition of use. Additionally, use of this medicine is not recommended during breastfeeding.


Q: What is the recommended storage temperature for Dutrav?

A: Official storage instructions state that the unopened medicine should be stored below 30 C or 25 C (depending on the regional label). Once the bottle is opened, it must be discarded after four weeks to maintain its stability and sterility.


Q: Can Dutrav be taken with blood pressure medication?

A: Co-administration with certain oral cardiovascular agents, such as systemic beta-blockers or calcium channel blockers (which are often used for blood pressure), is documented. These effects include the reported potential for low blood pressure (hypotension) or marked slowing of the heart rate (bradycardia).


Q: What are the signs of a severe allergic reaction to Dutrav?

A: Severe allergic reaction symptoms listed in regulatory consumer information include swelling or inflammation of the eye or trouble breathing. Other potential signs are swelling of the face, lips, tongue, or other parts of the body, rash, or hives.


Q: If I stop taking Dutrav suddenly, are there any known effects?

A: While specific abrupt withdrawal effects are not detailed in regulatory documents, the drug is intended for conditions requiring long-term management. Consistent with standard practice for chronic medications, any change in treatment, including stopping, is determined by a healthcare provider.


Q: Is it possible to take too much Dutrav?

A: Yes, taking too much is possible, and instructions are provided for what to do if an overdose occurs, such as rinsing the eye and contacting a medical professional. It is specified that the daily dose must not be exceeded.


Q: What is the difference between Dutrav and previous treatments for the same condition?

A: Clinical research reports on the measured outcome (Intraocular Pressure change) in comparison to using its individual components alone. Studies have also examined its use in patients who were insufficiently responsive to single-agent treatments, suggesting its role when previous therapies were not adequate.


Q: Will taking Dutrav interfere with my routine blood tests?

A: The beta-blocker component may increase the effect of antidiabetic medicines that lower blood sugar and may mask the physical signs and symptoms of acute hypoglycemia. This is relevant to monitoring blood glucose levels in blood tests.


Q: Is it okay to crush or chew the Dutrav tablet?

A: The regulatory dosage form of Dutrav is an ophthalmic solution (sterile eye drops). Since it is a liquid administered topically to the eye, the question of crushing or chewing an oral tablet does not apply to this medicine.


Q: Is Dutrav used to treat a chronic or temporary condition?

A: Dutrav is indicated for Open-Angle Glaucoma and Ocular Hypertension. These are described in regulatory documents as chronic conditions, which typically require long-term management and ongoing monitoring.


Q: Can I get Dutrav without a prescription?

A: Dutrav is strictly classified by regulatory authorities as a Prescription-only medicine (Rx). This means it cannot be obtained or dispensed without a valid prescription from a licensed healthcare professional.


Q: Do I need to change my diet while taking Dutrav?

A: Regulatory interaction sections focus only on medicines and do not mandate any specific dietary changes for most people. However, caution is advised for patients with diabetes, which is typically managed in consultation with a healthcare provider.


Q: Is Dutrav likely to cause dry mouth?

A: While dry eye is a common adverse reaction listed in regulatory information, dry mouth is generally not listed as a common or very common adverse reaction in the official consumer documents.


Q: Can Dutrav be used for conditions other than the one it is approved for?

A: Regulatory documents strictly list the approved indications as Open-Angle Glaucoma or Ocular Hypertension. Use for any condition other than the approved indications is considered off-label and is not addressed by official sources.


Q: Is Dutrav a medication that needs to be tapered off?

A: While no specific tapering schedule is mandated in the regulatory documents, the intended use for a chronic condition suggests that any change in treatment, including stopping or reducing the frequency of use, is determined by a healthcare provider.


Q: Why does the packaging for Dutrav include a warning about liver function?

A: Regulatory labeling advises caution in patients with hepatic impairment (liver problems). This caution is related to the systemic exposure and clearance of the active components, ensuring appropriate patient selection and monitoring in accordance with the regulatory risk assessment.

How should Dutrav be stored and disposed of?

How to Store and Dispose of DuoTrav (Travoprost/Timolol)

Official regulatory information defines specific requirements for storing, handling, and disposing of DuoTrav ophthalmic solution to maintain its stability and sterility.


Storage and Stability Constraints

Condition Regulatory Requirement
Unopened Storage Must be stored below 30°C.
In-Use Stability Must be discarded 4 weeks after first opening the bottle.
Container Rule The bottle must be kept tightly closed when not in use.
Protection Must be kept out of the reach and sight of children.

To prevent contamination, the dropper tip must not touch any surfaces, including the eye or surrounding areas. The medicine must be disposed of in accordance with local requirements for pharmaceutical waste, and should not typically be thrown into wastewater or household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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