Crystacide

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Crystacide

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Crystacide

Crystacide is a topical antiseptic cream used for the localized treatment of minor and superficial skin infections. It is generally available over-the-counter (OTC) in regions such as the UK, positioning it as a first-line treatment option for common skin conditions.


Quick Facts

Property Description
Active Ingredient Hydrogen Peroxide 1% (w/w)
Form Lipid-Stabilized Cream
Pharmacological Class Antiseptic and Disinfectant (Oxidizing Agent)
Common Use Superficial skin infections, Non-bullous Impetigo
Distinctive Feature No known bacterial resistance

Formulation and Therapeutic Role

Crystacide contains Hydrogen Peroxide 1% as its active ingredient. Hydrogen peroxide is a well-established oxidizing agent that exhibits broad-spectrum activity against various microorganisms, including bacteria, fungi, and certain viruses, making it a robust disinfectant.

A key feature of the Crystacide formulation is its lipid-stabilized cream base. This unique delivery system enhances the medicine’s adherence to the skin, which is designed to prolong the release and action of the hydrogen peroxide compared to simple aqueous solutions. This prolonged effect makes it highly suitable for treating localized bacterial infections, such as mild, localized non-bullous impetigo.

The medicine's role is significant in the context of antimicrobial resistance. The active ingredient, hydrogen peroxide, is not associated with bacterial resistance, which makes this product clinically recognized for its role in responsible antimicrobial stewardship, allowing for effective treatment of minor infections without contributing to the global issue of antibiotic resistance.

Regulatory References

  1. NICE guideline NG153 on Impetigo: antimicrobial prescribing

What side effects are possible with Crystacide?

Possible Side Effects and Safety Information

The safety profile of Crystacide (Hydrogen Peroxide 1% Cream), as documented in official regulatory sources, is primarily characterized by effects related to its application at the skin surface. The adverse reactions are classified mainly under Skin and Subcutaneous Tissue Disorders, reflecting the product's localized action.


Officially Documented Adverse Reactions

The most frequently reported local reactions, such as a mild burning sensation and the potential for contact dermatitis, are documented in regulatory labeling. The precise frequency for these reactions is generally listed as Not Known as it cannot be accurately estimated from the available data. The burning sensation is often officially described as a transient effect, meaning it is expected to last for only a short time after application.


General Safety Constraints

Official labeling includes specific safety constraints necessary for the appropriate use of the cream. The product is for external use only and contact with the eyes must be avoided. The cream should not be applied to large or deep wounds or to healthy, unaffected skin. Regulatory documents also note that the cream contains excipients, such as salicylic acid and propylene glycol, which are listed as potential causes of local skin irritation.


Special Population Notes

Regarding specific populations, the regulatory text advises that the use of Crystacide during pregnancy and lactation should only occur under medical guidance. The product is generally applicable to adults, the elderly, and children for localized use, without unique systemic safety constraints noted for these groups.

Overdose and Emergency Response

The official regulatory profile for Crystacide (Hydrogen Peroxide 1% Cream), a topical antiseptic, is defined by its low systemic risk. The product's Summary of Product Characteristics (SmPC) formally classifies the dedicated Overdose section as "Not applicable," establishing that no traditional systemic overdose profile from typical topical misuse is documented. Consequently, the focus of regulatory guidance is on managing accidental exposure and persistent adverse reactions.

Documented Emergency Response

Element Official Regulatory Statement
Overdose Presentation No specific systemic signs or symptoms of overdose are formally documented in the prescribing information.
Accidental Exposure Action Rinse off immediately with plenty of clean water if the cream accidentally contacts the eyes, nasal mucosa, mouth, or lips.
Urgent Help Required When Medical help must be sought if localized skin irritation persists, worsens rapidly, or if there is no improvement upon completing the treatment course.

Management of Potential Toxicity

No specific antidote is known for the active ingredient, hydrogen peroxide. Due to this constraint, management for potential toxicity resulting from accidental exposure or ingestion is generally limited to symptomatic and supportive treatment to maintain vital functions. No population-specific overdose considerations are explicitly listed in the official prescribing information. The guidance requires seeking professional assistance for persistent adverse reactions to ensure appropriate care and resolution.

Therapeutic Uses of Crystacide

What Crystacide Treats: Main Uses and Benefits

Crystacide is commonly used for managing localized bacterial skin infections, with a key indication being non-bullous impetigo in children and adults. It is relevant for easing symptoms related to inflammatory or irritative states, such as localized redness, mild inflammation, and the formation of characteristic golden-brown crusts. The cream may assist with managing the infection and supports patients during difficult episodes.

The cream is commonly used across conditions presenting with acute or disruptive episodes, such as minor trauma or localized irritation. This strategic use supports short-term symptomatic assistance and may assist with maintaining functional stability. The product is relevant for managing symptoms associated with microbial colonization and is considered relevant when supportive symptom management is appropriate.


Quick Fact: Relief for Superficial Skin Issues

The treatment is relevant for easing symptoms associated with acute therapeutic contexts and supports the overall goal of responsible antimicrobial stewardship.

Regulatory References

  1. National Institute for Health and Care Excellence (NICE) guidance on Impetigo

Eligibility and Restrictions for Use

Who Can and Cannot Use Crystacide?

Eligibility for Crystacide (Hydrogen Peroxide 1% cream) is strictly defined by regulatory documents, focusing on patient status and the condition being treated.


Contraindications and Restrictions

Category Regulatory Status
Absolute Contraindication Individuals with hypersensitivity (allergy) to the active substance (Hydrogen Peroxide) or any of the cream's excipients.
Age-Group Restriction Approved for use in Adults and the Elderly. Pediatric use is typically restricted to children aged 1 year and over for the treatment of impetigo, as outlined in national protocols.
Wound Type Exclusion Must not be applied to large or deep wounds or to healthy, uninfected skin, limiting its use to superficial skin infections.
Condition-Specific Exclusion Use is restricted in patients who are severely immunosuppressed or those presenting with widespread or recurring infections.
Pregnancy and Lactation Use during both pregnancy and lactation is subject to medical guidance as specified in the Summary of Product Characteristics (SmPC).

Official Eligibility Profile

Official documents define eligibility through a single absolute contraindication (hypersensitivity) and several conditional exclusions. These rules ensure that the medicine is reserved for patients who are 1 year of age or older, are not severely immunosuppressed, and only require treatment for a localized, superficial skin infection. Use in all special populations, including pregnant and breastfeeding individuals, requires professional assessment.

What should I know about interactions with other medicines?

️ Interaction Map: Interactions with other medicines and products — official regulatory information for Crystacide

Interaction scope

Category Official Regulatory Statement
Medicinal product categories with documented interactions Other topical preparations, particularly strong oxidizing agents, reducing agents, or chemically incompatible substances.
Specific interacting medicines (if explicitly listed) Iodine, permanganates, and other stronger oxidizing agents are explicitly listed in official product information.
Mechanistic basis of interactions (only if stated in label) Local chemical incompatibility, which may lead to chemical deactivation of one or both products or localized irritation.
Timing-based interaction rules (if applicable) Co-administration (simultaneous application) of other topical medicinal products on the same treatment area must be avoided.
Population-specific interaction notes (if applicable) None documented, as systemic interactions are absent.
Interaction-related restrictions Prohibited co-application with other topical agents.

Interaction classifications (high-level)

Classification Official Regulatory Statement
Interaction severity classification (as defined in official documents) The restriction is based on preventing local chemical incompatibility, not systemic toxicity.
Regulatory basis (EMA / FDA / etc.) Summaries of Product Characteristics (SmPC) and equivalent national regulatory information.
Interaction-context constraints (as defined in official documents) The constraint is limited to the local site of application; no systemic drug-drug interactions are documented.

Resulting interaction structure

Official interaction statements:

  • The product has no documented systemic pharmacokinetic (PK) interactions, such as those involving CYP enzymes or drug transporters.
  • Official labeling confirms that the primary constraint is a local pharmacodynamic incompatibility with other topical agents.

Connection to the overall interaction profile (2–4 sentences): Regulatory documents confirm the sole interaction constraint relates to avoiding local chemical reactions on the skin. This profile reflects the lack of systemic exposure, meaning no systemic drug-drug, transporter, food, or alcohol interactions are formally documented in the regulatory label. The entire constraint is centered on the site of application and chemical compatibility.

Mechanism of Action

How Crystacide works

The drug's mechanism is driven by the chemical properties of its active ingredient, hydrogen peroxide (H2O2), resulting in local oxidative reactions.


Direct Oxidative Microbicidal Action

This domain covers the immediate biochemical effect of hydrogen peroxide on microbial cellular structures and the subsequent oxidative disruption of these components. Hydrogen peroxide readily decomposes in the presence of tissue enzymes, primarily catalase, forming highly reactive hydroxyl radicals (cdot OH) and nascent oxygen (O2). This mechanism generates non-specific, destructive oxidative stress that rapidly denatures microbial proteins, damages cell membranes, and degrades nucleic acids, which results in the oxidative inactivation of microbial macromolecules.


Localized Tissue Interaction

This domain addresses the rapid-acting, superficial nature of the drug's effect and its restricted biological reach. Due to its chemical instability and rapid breakdown upon contact with tissue and blood, the oxidative effect of H2O2 is highly localized and short-lived. This restricted action profile means the primary mechanism is confined to the superficial layers of the skin, resulting in limited systemic diffusion of the active chemical species and restricting the oxidative reaction zone to the site of application.

Dosage and Administration Information

How to use Crystacide

Crystacide 1% cream is an external medication administered strictly via the topical route for localized skin use. The application protocol is standardized and is maintained consistently across adults, the elderly, and pediatric patients.


Dosing and Administration Schedule

The approved dosing regimen requires the application of a small amount of the cream, sufficient to create a thin layer covering the entire infected skin area. This process is generally repeated two to three times daily to the affected site. This frequency is part of a time-bound course, as the maximum continuous duration of treatment is set at three weeks (21 days).


Procedural Guidelines and Constraints

The area of application should be clean and prepared before the cream is applied. A key administration constraint is the requirement to strictly avoid contact with the eyes and all mucous membranes, such as the inside of the nose or mouth. The cream should also not be applied to large or deep wounds. Following the application, the area may optionally be covered with a non-occlusive dressing. A dry, visible film that may form on the skin after use is expected and can be washed off with water. These specifications define the precise procedural context for the medication’s use.

Recent Clinical Evidence

Crystacide: Recent Clinical Evidence


Evidence for Use in Localized Non-Bullous Impetigo

The research for this medicine was studied for localized non-bullous impetigo. The structure of the primary clinical evaluation involved a single pivotal Randomized Controlled Trial (RCT) that examined the cream against an active comparator treatment. The studies included patients, including both children and adults, who had been diagnosed with this condition. The research explored outcomes related to physical discomfort and monitored the change in presence of the bacteria commonly associated with impetigo. Findings were reported to track patterns in the observed changes of visible symptoms like crusting and weeping. However, the evidence base for localized impetigo largely rests upon this one trial, meaning comparative evidence is lacking against newer topical antibiotics.


Evidence for Use in Mild-to-Moderate Acne Vulgaris

Research has explored this cream was studied for mild-to-moderate acne vulgaris through short-term Randomized Controlled Trials (RCTs). These trials were evaluated in young adult populations, examining outcomes related to physical discomfort by counting changes in both inflamed and non-inflamed lesions over a defined time interval. The trials reported how lesion counts evolved during the study period when compared to an active comparator. Limited information is available for more severe forms of acne, and because follow-up durations were limited (usually 8 weeks), research does not provide insight into long-term changes.


Research Landscape for Antiseptic Role and Uncertainties

The cream's classification as an antiseptic is based primarily on non-clinical laboratory data rather than large-scale clinical trials for general superficial infections. Studies explored the properties of the active ingredient on a broad spectrum of microorganisms in vitro, and examined the specialized cream base. Long-term effects are not fully established through specific research. Additionally, while the main impetigo trial included a population of children and adults, data for certain groups remain insufficient, such as pregnant individuals. The research provides insight into short-term changes but has modest sample sizes, and follow-up durations were limited. Research is ongoing regarding the place of topical antiseptics alongside traditional antibiotics, and findings in this area may evolve over time.

Key Studies & References

  1. NICE Guidelines on Impetigo Management
  2. A placebo-controlled randomized clinical trial of a 1% hydrogen peroxide cream compared with a reference treatment in impetigo.

Frequently Asked Questions (FAQ)

Common questions about Crystacide (FAQ)

Q: Can children of all ages use Crystacide?

A: According to official regulatory guidance, the use of Crystacide cream is typically restricted to children aged 1 year and over. The product is generally not intended for the treatment of infants younger than 1 year.


Q: Is Crystacide safe to use if I am pregnant or breastfeeding?

A: Regulatory documents state that using the cream during pregnancy or lactation should only take place under medical guidance. This means that assessment by a healthcare professional is necessary before use.


Q: Can I use Crystacide if I have other skin conditions like eczema or psoriasis?

A: Crystacide is not indicated for treating conditions like eczema or psoriasis. Official product information notes that it contains excipients, such as salicylic acid and propylene glycol, which may cause localized skin irritation, including contact dermatitis. A healthcare provider can offer guidance regarding suitability if you have a chronic skin condition.


Q: Can Crystacide be used on an open cut or broken skin?

A: Official regulatory warnings state that the cream must not be applied to large or deep wounds. It is intended for superficial skin infections. For guidance on its use on minor cuts or abrasions, consultation with a healthcare professional is recommended.


Q: What percentage of the active ingredient is in the cream?

A: The cream contains Hydrogen Peroxide at a 1% w/w concentration. Studies indicate that this formulation, stabilized in a cream base, helps to prolong the action of the hydrogen peroxide compared to simple liquid solutions.


Q: Does using Crystacide make the skin more sensitive later on?

A: Official labeling reports adverse reactions that are primarily local and are often described as transient (short-lived), such as a mild burning sensation or potential for contact dermatitis. Official labeling does not include specific warnings regarding increased long-term skin sensitivity after the treatment course is finished.


Q: Does Crystacide help with general skin irritation?

A: The authorized indication for Crystacide is strictly the treatment of primary and secondary superficial skin infections. It is not indicated in regulatory documents for treating general or non-infectious skin irritation.


Q: Can Crystacide be used for non-bacterial skin issues?

A: While the cream is clinically indicated for specific skin infections, laboratory (in vitro) studies indicate that the active ingredient, hydrogen peroxide, is described as a potent antiseptic effective against a range of microorganisms, including bacteria, fungi, and certain viruses.


Q: How quickly does Crystacide typically start working, based on studies?

A: Regulatory documents indicate that the mechanism of the active ingredient involves a rapid destruction of microbial cells on contact. Clinical trials track outcomes by monitoring the change in presence of bacteria and visible symptoms (like crusting or weeping) over the defined short-term period.


Q: Does Crystacide contain steroids?

A: The official composition lists the active ingredient as Hydrogen Peroxide 1% and a full list of excipients. The product is not listed as containing any steroids.


Q: What is the difference between Crystacide and other common topical creams for skin infections?

A: The key difference lies in the active ingredient. Crystacide uses hydrogen peroxide, an oxidizing agent, whereas many other creams use traditional antibiotics. Regulatory documents note that, unlike traditional antibiotics, there are no known bacteria or fungi that develop resistance to hydrogen peroxide.


Q: What is the evidence like for Crystacide's use in younger populations?

A: The main clinical trial that supported the use of Crystacide for impetigo included a population of children and adults. However, research summaries also acknowledge that data for certain pediatric groups remain insufficient and trial sample sizes were modest.


Q: Does Crystacide interact with common over-the-counter pain relievers?

A: Official regulatory labeling confirms that the constraint for this product is a local incompatibility with other topical agents applied to the same spot. It is stated that there are no documented systemic drug-drug interactions, meaning no formal interaction with oral medicines like pain relievers is noted.


Q: Are there different strengths or formulations of Crystacide?

A: Official regulatory information describes the product as a 1% w/w cream formulation.


Q: If I miss an application of Crystacide, what should I do?

A: Regulatory guidance for similar topical products often suggests applying it as soon as it is remembered. If it is almost time for the next scheduled application, guidance suggests the missed one is generally skipped, and the regular schedule is continued.


Q: What is the typical shelf life of an unopened tube of Crystacide?

A: The official shelf life for an unopened tube of Crystacide cream is listed as 2 years. The storage section of the product information specifies keeping it below 25 C and avoiding freezing.


Q: Can the cream stain clothing or bedding?

A: Official warnings state that the active ingredient, Hydrogen Peroxide, has the potential to bleach fabric. Care is advised to avoid contact with clothing or bedding.


Q: Why is it important to check the expiration date on Crystacide?

A: Official regulatory documents require that the medicine must not be used after the expiry date printed on the packaging. This is required to ensure that the product maintains its effectiveness and stability throughout the treatment course.


Q: Do official documents mention any known interactions with herbal supplements?

A: The official interaction constraints are limited to preventing local chemical reactions with other topical agents. No systemic interactions with oral substances, including herbal supplements, are formally documented in the regulatory label.


Q: Is the main use of Crystacide consistent across different countries' regulatory bodies?

A: The main therapeutic indication for Crystacide across major regulatory regions is consistent: the treatment of superficial skin infections caused by organisms sensitive to hydrogen peroxide, including conditions like localized non-bullous impetigo.


Q: What are common reasons people stop using Crystacide?

A: Patients are instructed in official documentation to discontinue use if they experience signs of hypersensitivity or significant local irritation (such as a persistent rash, redness, swelling, or if the infection appears to worsen). These are the main safety-related reasons for discontinuation.


Q: Why might a doctor prescribe Crystacide over an oral medication?

A: Official documentation notes that hydrogen peroxide is not associated with the development of bacterial resistance. This highlights the product's role in antimicrobial stewardship for treating minor, localized infections.


Q: Does the cream need to be washed off after a certain time?

A: The official guidance states that a dry, visible film may form on the skin after application, and this film can be washed off with water. The instructions do not mandate that the cream must be washed off after a set time.


Q: Is Crystacide safe for people with known chemical sensitivities?

A: The medicine is strictly contraindicated in individuals with known hypersensitivity (allergy) to the active substance or any of the listed excipients. The excipients salicylic acid and propylene glycol are specifically noted in warnings as potential causes of local skin irritation.


Q: Why is the usage of Crystacide typically short-term?

A: The official administration schedule specifies a maximum continuous duration of treatment that should not exceed three weeks (21 days). This restriction defines the time-bound nature of the typical use for this product.


Q: Are there specific instructions for handwashing before and after applying Crystacide?

A: The official guidance requires that the area of application should be clean and prepared before the cream is used. For hygiene purposes, patient information materials often describe the practice of washing hands before and after application.

How should Crystacide be stored and disposed of?

How to Store and Dispose of Crystacide?

Crystacide 1% cream must be stored in a cool place at a temperature below 25°C and should not be frozen. To maintain product integrity, keep the cream in its original container and do not use it past the expiry date. Once the tube has been opened, the cream has a limited shelf life of 28 days.

For safety, the medicine must be kept out of the reach and sight of children.

Disposal must follow official pharmaceutical waste guidelines: do not dispose of via wastewater or household waste. Unused or expired product should be returned to a pharmacist for proper disposal, a measure required to protect the environment.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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