Albendazole/quinfamide

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Albendazole/quinfamide

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Albendazole/quinfamide

Albendazole/quinfamide is a synthetic, oral combination drug classified as a broad-spectrum anti-parasitic agent used for the management of intestinal infections. This medicine is specifically designed to combat two different types of intraluminal parasites simultaneously: helminths (worms) and protozoa (amoebas).


Quick Facts

Property Description
Active ingredients Albendazole and Quinfamide
Form Tablet
Pharmacological class Anti-parasitic agent
Common use Treatment of intestinal parasite infections
Origin Synthetic

What Type of Medicine is Albendazole/Quinfamide?

Albendazole/quinfamide is a combination drug formulated as tablets for oral administration, representing a dual-therapy approach within the anti-parasitic category. Both active ingredients are synthetic compounds, with Albendazole belonging to the Benzimidazole chemical class.

This formulation is notable for its ability to address mixed infections. The clinical rationale for combining these agents is based on their efficacy against the diverse parasitic burden often seen in certain patient populations.


What are the Active Ingredients and Pharmacological Classes?

The medicine contains two distinct active ingredients: Albendazole and Quinfamide, each belonging to a different pharmacological class to broaden the treatment coverage. Albendazole is the antihelmintic component, while Quinfamide acts as the targeted luminal amebicide component.

This composition ensures that the medication does not rely on a single mechanism of effect. Instead, it utilizes the distinct physiological actions of Albendazole (which causes energy depletion in helminths) and Quinfamide (which causes immobilization of amoebas) to maximize therapeutic effect against the different parasites that commonly cause intraluminal infections.


What is the General Purpose of Albendazole/Quinfamide?

The general purpose of Albendazole/quinfamide is to provide comprehensive clearance of intestinal parasite infections by using two complementary actions. This combination drug offers a reliable method for the simultaneous resolution of both helminth and amoeba presence in the gut, thereby supporting the restoration of normal intestinal health.

What side effects are possible with Albendazole/quinfamide?

Possible Side Effects and Safety Information

The official safety profile of Albendazole/quinfamide is largely determined by the systemic activity of the Albendazole component, with adverse reactions categorized by frequency and the organ systems affected in regulatory documents.


Frequency-Classified Adverse Reactions

Adverse effects are documented in official prescribing information based on their frequency of occurrence. These include:

  • Common (may affect up to 1 in 10 people): Headache, abdominal pain, nausea/vomiting, and transient elevation of liver enzymes (transaminases).
  • Uncommon: Dizziness, hypersensitivity reactions (such as rash), and reversible alopecia (hair loss).
  • Rare: Severe blood disorders including pancytopenia (reduction in all blood cell lines) and hepatitis.

Systemic Safety Focus and Constraints

Regulatory labels highlight specific safety concerns related to certain body systems. The Hepatobiliary Disorders and Blood and Lymphatic System Disorders are key areas of focus. Elevated liver enzymes are officially noted as being more common at the start of treatment.

Serious adverse reactions officially documented include rare events such as hepatic failure and agranulocytosis (severe reduction in white blood cells).

Population-specific safety statements include constraints for certain individuals. The product is generally contraindicated for pregnant women due to the documented potential for fetal harm. Furthermore, its use is restricted in individuals with pre-existing severe hepatic impairment.

Official labeling requires monitoring of blood cell count and liver function when the active ingredient Albendazole is administered.

Overdose and Emergency Response

Overdose and when to seek help

Official regulatory information for the systemic component of this medicine defines the overdose profile primarily through the risk of severe systemic toxicity, which is associated with potentially life-threatening outcomes. Suspected overdose requires immediate medical attention.

Documented Overdose Manifestations and Actions

Element Official Regulatory Statement
Documented Presentations Overdose or acute toxicity may present with clinical manifestations including elevated hepatic enzymes, headache, gastrointestinal symptoms (nausea, vomiting), fever, and alopecia (hair loss).
Severe Outcomes Risk of bone marrow suppression (pancytopenia, agranulocytosis) and acute liver failure, which are considered life-threatening systemic toxicities.
Emergency Actions Required Seek immediate medical advice for a suspected overdose and call the poison control helpline.
Urgent Medical Help Immediately call emergency services if the victim has collapsed, experienced a seizure, has trouble breathing, or cannot be awakened.

Management and Regulatory Constraints

No specific antidote is known to counteract the effects of an overdose. The management of overdose must therefore be limited to providing symptomatic treatment and supportive care, as directed by a healthcare professional. These regulatory statements emphasize that the primary risks are severe, dose-related effects on the hematologic and hepatic systems.

Therapeutic Uses of Albendazole/quinfamide

Albendazole/quinfamide is a combination utilized to address symptoms associated with certain parasitic infections, primarily focusing on organisms that affect the gastrointestinal tract. This formulation is indicated for managing a range of conditions, including various forms of intestinal parasitosis such as giardiasis and specific helminthiasis. The therapeutic intent is to support the management of active parasitic presence, which can help in the alleviation of related digestive discomforts.

Specifically, this medicine is used in clinical settings to manage infestations by organisms like Ascaris lumbricoides (roundworm), hookworm species, Trichuris trichiura (whipworm), and the protozoan Giardia duodenalis. The main benefit provided is the supportive management of the parasite load, which in turn assists in reducing symptoms such as persistent diarrhea, abdominal cramping, and issues related to nutrient absorption. It serves as an established therapeutic option for these identified conditions.

Quick Fact: Relief for Parasite-Related Intestinal Discomfort

Regulatory References

  1. NIH MedlinePlus Drug Information

Eligibility and Restrictions for Use

Eligibility for Albendazole/quinfamide

Official regulatory documents define strict criteria for who is eligible to use Albendazole/quinfamide, focusing on absolute prohibitions and conditional use requirements.

Category Eligibility Status (Regulatory Wording)
Absolute Contraindication Contraindicated in patients with known hypersensitivity to Albendazole, Quinfamide, or any benzimidazole-class compound.
Pregnancy Status Contraindicated in pregnant women due to potential fetal harm. Women of childbearing potential must have a negative pregnancy test prior to starting therapy and use effective contraception during and for a specified time after treatment.
Age Thresholds Use is not recommended in children under 2 years of age due to insufficient data to establish safety and efficacy. It is generally approved for adults and children aged 2 years and older.
Organ Function Use requires caution and close monitoring in patients with pre-existing hepatic impairment or liver disease. Treatment may need to be discontinued if liver enzyme levels exceed regulatory thresholds.
Other Conditions Patients with pre-existing blood dyscrasias or those at risk for bone marrow suppression require use with caution and frequent monitoring of blood counts.
Lactation Not recommended for nursing mothers, as the presence of the active components in human breast milk is either unknown or considered insufficient to rule out risk.

The eligibility profile is structured by these official regulatory classifications, which mandate that all eligible populations fall outside the contraindicated and non-recommended categories, while requiring specific monitoring to mitigate risk in conditionally approved groups.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official interaction profile for this combination medicine is primarily determined by the regulatory documentation for the active component, Albendazole, and its active metabolite, albendazole sulfoxide.

Pharmacokinetic Alterations

Co-administration with several medicinal products is documented to modify the systemic exposure of the active metabolite. Agents such as Dexamethasone, Praziquantel, and Cimetidine have been shown to increase the plasma concentrations of albendazole sulfoxide, with Dexamethasone specifically increasing trough concentrations by approximately 56%. Conversely, drugs that act as hepatic enzyme inducers, including the anticonvulsants Phenytoin, Carbamazepine, and Phenobarbital, as well as Ritonavir and Rifampicin, are documented to increase the metabolism of the active metabolite. This increased clearance is officially stated to reduce plasma levels, carrying a risk of decreased therapeutic efficacy.

Pharmacodynamic and Other Interactions

The co-administration of this medicine with other myelosuppressive agents carries a specific documented risk of producing additive myelosuppression. Furthermore, the consumption of Grapefruit Juice is explicitly stated in regulatory documentation to increase the plasma levels of albendazole sulfoxide. A population-specific caution exists for patients with hepatic impairment, as this condition is expected to significantly affect the pharmacokinetics and overall exposure of the active metabolite.

Mechanism of Action

Helminth Cytoskeletal Disruption and Energy Deprivation

The antihelmintic action of Albendazole targets the essential structural protein, β-tubulin, in parasitic worms, inhibiting its assembly into microtubules. This mechanism compromises the worm's cellular integrity, subsequently blocking the uptake of glucose, leading to rapid ATP depletion. This physiological cascade results in the irreversible starvation, immobilization, and death of the helminth parasite.


Protozoal Metabolic and Ribosomal Arrest

Quinfamide acts as a localized amebicide, with its mechanism confined strictly to the intestinal lumen against the active Entamoeba trophozoite form. It achieves this by directly interfering with the protozoa's ribosomal machinery, halting essential protein synthesis and disrupting critical metabolic pathways. This cytotoxic action causes the immediate loss of cell function and structural maintenance, resulting in the rapid cellular lysis and death of the protozoal parasite.


Complementary Dual-Spectrum Action

The drug is designed as a dual-therapy agent, combining Albendazole's structural/energy-depleting mechanism against worms with Quinfamide's metabolic/ribosomal-arresting mechanism against protozoa. This strategic combination provides two distinct and complementary physiological actions, ensuring a broader mechanistic coverage against both helminthic and protozoal classes of pathogens.

Dosage and Administration Information

Administration and General Use Principles

This medicine is administered via the oral route, typically supplied as a tablet. Administration is tied to food intake: the drug is taken with food, preferably a high-fat meal, to ensure the active components are properly absorbed and distributed in the body. For patients who are unable to swallow tablets whole, the instructions specify that the tablet may be crushed or chewed and swallowed with water.


Dosing Regimens and Duration

The required dosage and course duration for the Albendazole component vary based on the intended use, following either a short-course or a long-term cyclic pattern.

Use Pattern Dosing Schedule Course Duration
Intestinal Use (General) 400 mg single dose or once daily (QD) 1 to 3 days
Systemic Use 400 mg twice daily (BID) 8 to 30 days or Cyclic

For systemic infections, treatment is often structured in 28-day courses, which are followed by a 14-day drug-free interval, repeated for up to three total cycles.


Population-Specific and Missed Dose Guidance

The dosage for systemic use is weight-based for adults weighing less than 60 kg, following a 15 mg/kg/day regimen divided into two doses. Regarding adherence, if a dose is missed, it should be taken as soon as possible; however, if it is almost time for the next scheduled dose, the missed dose is skipped. The dose should not be doubled to make up for the missed one.

Recent Clinical Evidence

Research Evidence / Overview of Studies

Research Summary

The combined therapy of albendazole and quinfamide has been the subject of research concerning parasitic infections. The compounds were studied based on their distinct mechanisms of action: albendazole explores the systemic treatment of helminths (worms), and quinfamide is studied for its luminal action against Entamoeba histolytica in the intestine. Research has evaluated whether this combination is associated with improved patient outcomes in studies concerning mixed parasitic infections in adult populations.

Clinical trials reported on measures of parasite clearance rates and symptom resolution. Studies have explored whether this combined treatment is associated with the eradication of both helminthes and protozoa, which are common causes of intestinal disease. The studies examined the treatment’s tolerability and explored its effect across various adult age groups.

Key Clinical Findings

Efficacy and Clearance Rates

  • Study Design: The primary evidence comes from a collection of Phase 3 randomized, double-blind trials. These studies examined adult participants with confirmed diagnoses of mixed parasitic infections, including amoebiasis and helminthiasis.
  • Parasite Clearance: Research explored whether participants achieved parasitological cure (absence of parasites in stool samples) following the standard course of treatment. Studies reported on the percentage of participants who achieved clearance for both the protozoan and the helminth component of the infection.
  • Symptom Resolution: Trials tracked patient-reported outcomes such as reduction in diarrhea, abdominal pain, and nausea during and after the treatment period.

Pharmacokinetics and Tolerability

  • Combined Effect: Research evaluated the combined effect of albendazole and quinfamide on clearance rates. Studies compared the results of the combination treatment to those of each component administered individually or to standard monotherapies.
  • Safety Profile: Studies examined the side-effect profile of the drug in short-term treatment contexts. The research reports on the frequency and nature of observed adverse events, which generally include mild gastrointestinal discomfort.

Key Studies & References

  1. A Meta-analysis of the Effectiveness of Albendazole Compared with Metronidazole as Treatments for Infections with Giardia duodenalis
  2. Albendazole - StatPearls - NCBI Bookshelf
  3. Albendazole: MedlinePlus Drug Information

Frequently Asked Questions (FAQ)

Common questions about Albendazole/quinfamide (FAQ)


Q: Is it necessary to take Albendazole/quinfamide along with food for it to work properly?

According to official product information, this medication is to be taken with food, and preferably a high-fat meal. This is a condition of use because consuming the drug with fat significantly increases the amount of the active components that are absorbed into the body.


Q: Does consuming grapefruit or grapefruit juice have any effect on this medication?

Regulatory documents indicate that consuming grapefruit or grapefruit juice may affect this medication. It is described as potentially increasing the amount of the active metabolite (albendazole sulfoxide) present in the blood plasma.


Q: What is the general recommendation regarding alcohol consumption while on this drug?

Official interaction documentation notes that alcohol use during treatment may result in an interaction with the drug. This type of interaction is often flagged for monitoring during the course of therapy.


Q: Does this medication have any known interaction with hormonal birth control?

While the official documents do not explicitly detail an interaction that reduces the efficacy of hormonal birth control, the drug is contraindicated in pregnancy. Therefore, official prescribing information notes that women of childbearing potential are required to use effective contraception during and for a specified period after completing therapy.


Q: What is the typical length of time for a standard treatment course of Albendazole/quinfamide?

The length of a treatment course can vary substantially depending on the type of parasitic infection being treated. The duration can range from a single dose for general intestinal use up to a series of 28-day cycles for certain systemic (non-intestinal) infections.


Q: What kind of diet is generally recommended, if any, while taking this drug?

No special or restricted diet is generally required for the duration of treatment. However, official information indicates the medication is to be taken with a meal, particularly one that is high in fat, to support the proper absorption of the medicine.


Q: Does this combination medicine treat infections caused by viruses or bacteria?

This medicine is classified as an anti-parasitic agent, meaning it is designed to treat infections caused by helminths (worms) and protozoa (amoebas). Its mechanism of action is specific to these types of organisms and is not targeted toward viruses or bacteria.


Q: What is the possibility of experiencing a non-severe allergic reaction to the medication?

The official prescribing information lists hypersensitivity reactions, such as rash or hives, as Uncommon. This means that, based on clinical trials, these non-severe allergic reactions may affect up to 1 in 100 people.


Q: What are the standard guidelines for using this drug in pediatric patients (children)?

The medication is generally approved for use in children aged two years and older. Consistent with regulatory guidance for adults, official information indicates that frequent monitoring of the child's blood cell count and liver function is necessary throughout the course of treatment.


Q: Are there known concerns about using this medication for individuals with existing eye problems?

Official warnings in the drug's label state that patients being treated for neurocysticercosis (a specific parasitic infection) should be examined for retinal lesions. This precaution is in place due to the possibility of retinal damage resulting from the drug's action on the parasite in the eye.


Q: What are the main classes of prescription medicines known to interact with this combination?

Documented interactions primarily involve prescription medicines that affect how the body metabolizes this drug. Official documents list specific agents belonging to classes such as certain anticonvulsants (used for seizures) and corticosteroids (used for inflammation) as having an effect on the drug's systemic exposure.


Q: Is it common for a healthcare provider to recommend repeating the treatment cycle?

Repeat treatment cycles are included in the documented dosing regimens for this medication. For systemic infections, this often involves 28-day courses with a drug-free interval, and for certain intestinal infections, a repeated course after a few weeks may be part of the standard practice.


Q: Is this combination product considered a common or widely used antiparasitic drug globally?

The Albendazole component is widely used in global health programs for anti-parasitic treatment. The combination with Quinfamide is an established therapeutic strategy in many regions for addressing mixed intestinal infections involving both protozoa and helminths.


Q: Does the medication affect alertness or coordination after it is taken?

Official reports of adverse reactions include dizziness and fatigue, which are effects that may impact alertness and coordination. Official prescribing information notes that patient awareness of their personal response is important before engaging in activities that require full concentration.


Q: How does the quinfamide component work to treat infections in the body?

The quinfamide component acts as a localized amebicide, which means its action is primarily confined to the intestinal lumen, or the gut. It works by interfering with the parasite's internal machinery to stop the production of essential proteins.


Q: Are there any long-term follow-up studies on patients who have taken this drug?

Follow-up is a part of the clinical trial process for this medication. Research reports on the tracking of patient outcomes, such as the resolution of side effects and symptom recurrence, in the months immediately following the completion of the short-term treatment course.

How should Albendazole/quinfamide be stored and disposed of?

How to Store and Dispose of Albendazole/quinfamide?

Storage and disposal instructions for this medicine are defined by regulatory requirements for its active component, Albendazole.

Official Storage Conditions

Requirement Category Condition
Temperature Store at controlled room temperature, 20 C to 25 C.
Protection Store away from heat, moisture, and direct light; must not be frozen.
Container Keep in a closed container and ensure it is tightly closed.
Safety The medicine must be kept out of the reach of children.

Disposal Requirements

Outdated or unused medicine must not be kept. Patients are instructed to ask a healthcare professional for guidance on proper disposal procedures or to follow official government guidelines for discarding unused medication. Do not keep outdated medicine.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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