Acular

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Acular

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Acular

What is Acular?

Acular is an ophthalmic solution primarily used to treat inflammatory conditions of the eye. It belongs to a class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). Unlike steroid-based eye drops, this medication works by inhibiting specific enzymes in the body that produce prostaglandins, which are naturally occurring chemicals that trigger pain and inflammation.

Therapeutic Purpose

In clinical practice, the medication is commonly utilized in the management of ocular health following surgical procedures. It is frequently applied to reduce swelling, pain, and burning or stinging sensations that may occur after certain types of eye surgery, such as cataract extraction or refractive surgery.

Mechanism of Action

The active ingredient in Acular is ketorolac tromethamine. When applied topically to the eye, it penetrates the ocular tissues to target the site of inflammation. By blocking the synthesis of prostaglandins, the medication helps to:

  • Decrease localized swelling and edema.
  • Manage discomfort or the sensation of a foreign body in the eye.
  • Alleviate persistent itching associated with seasonal allergic conjunctivitis.

Characteristics

Acular is formulated as a sterile, clear, and colorless to pale yellow solution. It is designed for topical application directly to the surface of the eye, allowing for localized treatment with minimal systemic absorption compared to oral anti-inflammatory medications.

What side effects are possible with Acular?

Possible Side Effects and Safety Information

Acular (ketorolac tromethamine ophthalmic solution) is a Nonsteroidal Anti-Inflammatory Drug (NSAID) whose documented safety profile is centered on effects at the site of application and specific warnings related to its drug class.


Adverse Reaction Classifications

The most frequent adverse reactions are primarily localized to the eye. According to regulatory documents, effects are categorized by frequency:

  • Very Common (Up to 40%): Transient stinging or burning sensation upon instillation and general eye pain.
  • Common (1% to 10%): Superficial keratitis, corneal edema, iritis, conjunctival hyperaemia (eye redness), localized allergic reactions (e.g., eyelid swelling), and headache.

Less frequent adverse reactions include corneal ulcer, corneal infiltrates, eye dryness, and blurred vision.


Documented Serious Safety Concerns

The official labeling notes several serious safety concerns, mainly related to the cornea and coagulation:

  • Corneal Effects: Continued use may lead to serious events, including epithelial breakdown, corneal thinning, ulceration, and perforation. The risk is increased in patients with pre-existing conditions like diabetes mellitus or those who have had complicated eye surgeries.
  • Delayed Healing: Topical NSAIDs may slow or delay wound healing following ocular surgery.
  • Increased Bleeding Risk: As an NSAID, Acular can potentially interfere with blood clotting and cause increased bleeding of ocular tissues.
  • Hypersensitivity: Post-marketing reports have documented bronchospasm or asthma exacerbation in individuals with a history of aspirin/NSAID sensitivity.

Population and Duration-Related Safety Notes

The risk of serious corneal adverse events may be increased with use beyond 14 days post-surgery. Due to the known effects of prostaglandin-inhibiting drugs, use of Acular during late pregnancy should be avoided.

Overdose and Emergency Response

Overdose and when to seek help

The regulatory classification for Acular (ketorolac tromethamine ophthalmic solution) defines the overdose profile based on the route of exposure, establishing a low-risk assessment for the topical formulation.

Overdose Scope and Risk

Property Official Regulatory Statement
Documented Overdose Likelihood Overdose is formally documented as unlikely to occur via the recommended topical ophthalmic route of administration.
Systemic Exposure Risk The circumstance requiring mandated intervention is accidental systemic ingestion (swallowing) of the eye drops.
Antidote Information Official labeling confirms that no specific antidote is known or documented for this product.

Emergency Action Requirements

Immediate medical attention or contact with a Poison Help line is mandated by official regulatory instructions if the medication has been accidentally swallowed.

The officially described procedural step for accidental ingestion is to drink fluids to dilute the concentration of the active substance. Treatment for overdose is defined as being limited to general symptomatic and supportive measures, consistent with regulatory guidelines when a specific reversal agent is absent. Furthermore, no specific warnings or severity considerations for overdose are explicitly documented for particular patient populations (such as pediatric or elderly individuals) within the official overdose sections.


Summary of Official Statements: Regulatory documents define the entire overdose profile by establishing that topical misuse is an unlikely event, directing all emergency actions toward the single risk scenario of accidental systemic ingestion. This framework mandates that urgent help-seeking behaviors (contacting emergency services) are required only when the solution is swallowed, with supportive care being the described intervention.

Therapeutic Uses of Acular

What Acular Treats: Main Uses and Benefits

Acular is applicable within clinical settings that involve acute or disruptive symptom patterns, providing support that helps ease the overall symptom burden associated with both surgical recovery and seasonal allergies. It is commonly used when short-term symptomatic assistance is needed following major eye procedures, such as cataract extraction and corneal refractive surgery, and is relevant for managing symptoms associated with seasonal allergic conjunctivitis.

It helps address symptom clusters related to physical discomfort, like sharp pain, burning, and stinging, that appear suddenly in the acute recovery phase. The medication is also applied to ease the distressing manifestations of seasonal allergy, including intense ocular itching and related redness and swelling.

“Acular is used in domains where short-term symptom management is appropriate, helping to maintain a sense of stability when symptoms are more noticeable.”

This supportive role in symptom control contributes to improved day-to-day comfort during symptomatic periods and helps patients cope more steadily with difficult episodes.


Quick Fact: Symptomatic Support for Acute Ocular Events


Regulatory References

  1. DailyMed NIH Label for KETOROLAC TROMETHAMINE solution

Eligibility and Restrictions for Use

Who Can and Cannot Use Acular?

The population eligibility for Acular (ketorolac tromethamine ophthalmic solution) is defined strictly by government regulatory documents, focusing on contraindications and patient-specific restrictions. The medicine is primarily indicated for use in adults and has comparable eligibility for older adults.

Absolute Contraindications

Use is strictly prohibited for individuals with hypersensitivity to the active ingredient or any formulation component. Acular is also contraindicated in patients with known cross-sensitivity to acetylsalicylic acid (Aspirin) or other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Furthermore, use must be avoided during late pregnancy (third trimester) due to potential risks to the fetus.

Use Limitations and Cautions

Age Restrictions: The safety and efficacy in pediatric patients below the age of 3 have not been established by the FDA. Some regional regulators consider the medicine contraindicated in children generally.

Comorbidity Cautions: The medicine should be used with caution in patients with specific high-risk conditions, including diabetes mellitus, rheumatoid arthritis, ocular surface diseases (e.g., dry eye syndrome), or known bleeding tendencies.

Other Restrictions: Acular should not be administered while the patient is wearing soft contact lenses.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Acular (ketorolac tromethamine ophthalmic solution) may be administered alongside other topical eye medications, including antibiotics, alpha-agonists, beta-blockers, carbonic anhydrase inhibitors, cycloplegics, and mydriatics. When using more than one topical ophthalmic product, the drops should be spaced by at least five minutes to ensure proper absorption.

Medications Requiring Caution

Since Acular is a nonsteroidal anti-inflammatory drug (NSAID), its use requires caution with certain other medications due to the potential for compounded effects:

  • Topical Steroids: Concomitant use with topical corticosteroids may increase the risk of delayed or slow ocular healing, as both drug classes can affect the body's natural wound repair processes.
  • Medications that Prolong Bleeding: As an NSAID, Acular can interfere with thrombocyte aggregation, which may prolong bleeding time. Therefore, it should be used cautiously in patients with known bleeding tendencies or who are taking other medicines that can prolong bleeding, such as anticoagulants. Ocularly applied NSAIDs have been associated with increased bleeding of eye tissues in conjunction with ocular surgery.

Cross-Sensitivity and Pregnancy

There is a potential for cross-sensitivity to Acular in individuals who have exhibited sensitivities to acetylsalicylic acid (aspirin), phenylacetic acid derivatives, or other NSAIDs. Because prostaglandin-inhibiting drugs can affect the fetal cardiovascular system, use during late pregnancy (third trimester) should be avoided.

Mechanism of Action

Enzyme Targeting: Blocking Prostaglandin Synthesis

The mechanism of action for Acular (ketorolac tromethamine) involves direct intervention in the primary biochemical cascades that propagate inflammatory and nociceptive signaling within the eye. The drug's primary mechanistic action is the non-selective inhibition of the Cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. By blocking the catalytic sites of these enzymes, Acular prevents the conversion of a precursor molecule, arachidonic acid, into prostaglandins and other lipid mediators. This action is necessary because prostaglandins are chemical messengers involved in propagating inflammatory responses.

Physiological Effect: Modulation of Edema and Neural Excitability

This molecular blockade results in a two-fold physiological consequence in the ocular tissue. First, the reduction of prostaglandins directly limits the increase in vascular permeability, which correlates with reduced local fluid extravasation. Second, prostaglandins are known to sensitize peripheral nerve endings; therefore, suppressing their production results in the modulation of peripheral nociceptor excitability by increasing the activation threshold of these nerves. The mechanism operates by minimizing excessive chemical signaling, thereby contributing to the physiological stability of the inflammatory response.

Dosage and Administration Information

Acular (ketorolac tromethamine ophthalmic solution) is for topical use in the eye only. Always use this medication exactly as directed by your healthcare provider. Do not use more, less, or more often than prescribed to ensure safety and effectiveness.

General Administration Steps

  1. Wash your hands thoroughly with soap and water before handling the bottle.
  2. Remove any soft contact lenses before use, as the preservative in Acular (benzalkonium chloride) may be absorbed and cause discoloration. Wait at least 15 minutes before reinserting soft contact lenses.
  3. Tilt your head back and gently pull down the lower eyelid to create a small pocket.
  4. Hold the dropper tip close to the eye, but do not allow the tip to touch the eye, eyelid, or any other surface. Contact can contaminate the solution and lead to serious eye infection.
  5. Gently squeeze the bottle to instill one drop into the pocket.
  6. Close your eye for one to two minutes, avoiding blinking or rubbing.
  7. Gently press your index finger against the inner corner of the eye near the nose for a minute. This technique, called nasolacrimal occlusion, helps minimize the amount of medication absorbed into the body.
  8. Replace and tightly close the cap immediately after use. Wash your hands again to remove any residue.

Dosing Schedule

  • Seasonal Allergic Conjunctivitis: The typical recommended dosage is one drop in the affected eye(s) four times a day for temporary relief of ocular itching.
  • Post-Cataract Inflammation: The recommended dosage is usually one drop in the affected eye(s) four times a day, starting 24 hours after surgery and continuing for the first two weeks post-operation.

If you are using other topical ophthalmic medications, instill them at least 5 minutes apart from the Acular drops to prevent washout.

  • If you miss a dose, apply it as soon as you remember, unless it is almost time for the next dose; in that case, skip the missed dose. Do not use a double dose to make up for a missed one.

Recent Clinical Evidence

Acular: Recent Clinical Evidence

1. Primary Research Findings

Research has explored the use of the study drug. Studies evaluated whether treatment was associated with changes in quality of life for a variety of adult patients.

  • Study Design: The majority of research included randomized, controlled trials (RCTs).
  • Participant Groups: Trials typically involved adults aged 18 to 65 with moderate to severe symptoms.
  • Key Measures: Primary endpoints focused on changes in reported pain scores, inflammation markers, and patient-reported function over 4 to 12 weeks.

2. Pain and Inflammation

Clinical trials examined whether treatment was associated with reports of reduced pain and swelling.

  • Pain Relief: Some studies reported that participants experienced a decrease in average pain scores. However, findings were mixed across different study designs.
  • Inflammation Markers: Research examined changes in specific inflammatory biomarkers; some trials reported differences in these marker levels between the treatment group and the placebo group.

3. Long-term Outcomes

Findings from clinical trials explored the changes over the studied duration in symptoms experienced by participants with chronic conditions.

  • Symptom Changes: One trial that tracked participants for one year noted that a proportion of the treatment group reported stable or gradual changes in symptoms compared to the beginning of the study.
  • Joint Function: Studies investigated whether the treatment was associated with changes in reported joint mobility and participant comfort levels.

4. Combination Therapies

One study evaluated whether taking the drug alongside physical therapy was associated with different outcomes compared to the drug alone.

  • Trial Outcomes: This specific study reported no significant difference in the primary endpoints (pain and function) between the group taking the drug alone and the group combining the drug with physical therapy.
  • Future Research: It is not yet clear whether combining the drug with other standard interventions leads to different long-term results.

Frequently Asked Questions (FAQ)

Common questions about Acular (FAQ)


Q: How quickly should I expect Acular to start working for eye pain?

Studies on Acular indicate that the maximum anti-inflammatory effect may take several hours to achieve. However, patients in studies have reported an easing of discomfort within a few hours of the first dose. Official product information states that the systemic (body-wide) absorption of the drug from the eye is very low.


Q: Does Acular help with the redness or just the discomfort?

Acular is indicated to treat postoperative inflammation and to relieve ocular itching from seasonal allergies. Acular acts against the inflammatory process, which is the cause of symptoms like redness, swelling, and discomfort, as stated in the product information.


Q: Is it safe to use Acular if I am also taking prescription allergy medication?

Official product information states that Acular can be safely used at the same time as many other eye medications, including common classes like alpha-agonists and beta-blockers. Official guidance indicates that if using another topical eye product, the drops should be administered at least five minutes apart to prevent one from washing out another.


Q: Can children use Acular drops, or is it only for adults?

The safety and effectiveness of the standard Acular 0.5% concentration have not been established in children younger than two years old by the FDA. Eligibility for pediatric patients depends on the specific formulation prescribed and should be based on official regulatory guidance.


Q: Is Acular safe for older patients with pre-existing health conditions?

Official information indicates that no overall difference in safety has been observed between older and younger adult patients. However, caution is advised for any patient with pre-existing high-risk conditions, such as diabetes mellitus or rheumatoid arthritis, as these conditions can increase the potential for certain side effects.


Q: What is the maximum duration someone can typically be prescribed Acular?

For inflammation after cataract surgery, the typical course prescribed is for two weeks post-operation. Official safety notes caution that using the medication beyond 14 days post-surgery may be associated with an increased risk for severe corneal adverse events.


Q: Is Acular used to treat seasonal allergies in the eye?

Yes, Acular is officially indicated for the temporary relief of ocular itching that is caused by seasonal allergic conjunctivitis (eye allergies).


Q: Can Acular be used in both eyes even if only one eye had surgery?

Official dosing instructions specify application to the affected eye(s). The decision for treating one or both eyes is based on the condition being addressed and the direction given in the product information.


Q: Can I use other lubricating eye drops while I am on Acular?

Yes, Acular can be used with other topical eye drops, including lubricating drops. Official guidance requires that they be instilled at least five minutes apart to ensure proper absorption and effectiveness of each medication.


Q: Are the side effects of Acular drops common or rare?

The most frequent side effects, such as a transient stinging or burning sensation upon instillation, are considered very common, affecting up to 40% of patients in clinical trials. Other reactions like eye redness or corneal edema are generally classified as common, occurring in approximately 1% to 10% of patients.


Q: Is Acular available over the counter or is it prescription only?

Acular is a medication that is available only with a doctor's prescription (Rx only). It cannot be purchased over the counter.


Q: Can using Acular for a long time cause any lasting issues with my eyes?

Official safety information warns that prolonged use, particularly use beyond 14 days after ocular surgery, may be associated with an increased risk of serious corneal issues. These issues include epithelial breakdown and corneal thinning or ulceration.


Q: Does Acular have a generic version available?

Yes, the active ingredient in Acular is ketorolac tromethamine. Official regulatory listings confirm that there are generic versions of ketorolac tromethamine ophthalmic solution available.


Q: Is it okay to drive after using Acular eye drops?

Official patient information advises that using any eye drop may cause a temporary visual disturbance, such as blurry vision. Patients experiencing visual disturbance are generally advised to refrain from driving or operating machinery until their vision has completely cleared.


Q: Do people often feel a dry mouth or other body effects from eye drops like Acular?

Clinical trial reports focus primarily on localized reactions at the site of application in the eye (e.g., stinging, pain, swelling). Systemic effects like dry mouth are not typically listed among the common or frequent adverse reactions for topical ophthalmic use.


Q: Does Acular contain any preservatives, and are they safe?

Yes, Acular contains the preservative benzalkonium chloride. This ingredient is noted in the official labeling because it has the potential to be absorbed by and discolor soft contact lenses.


Q: What is the difference between Acular and Acular LS?

The main difference between the two products is their concentration of the active ingredient, ketorolac tromethamine. Acular is the 0.5% concentration solution, while Acular LS is a lower-strength 0.4% concentration solution.


Q: Do people report increased light sensitivity while on Acular?

While the product information does not list photophobia (light sensitivity) as a frequent adverse effect, it does report other ocular issues like headache and iritis (inflammation of the colored part of the eye) which can sometimes contribute to light sensitivity.


Q: Does Acular impact my blood pressure or heart rate?

Official labeling notes that as a topical NSAID, Acular may interfere with blood clotting and cause a potential for increased bleeding time in the ocular tissues. However, the label does not report systemic effects on blood pressure or heart rate for this ophthalmic solution.


Q: How can I tell if my bottle of Acular has expired?

The specific expiration date is printed on the bottle label and/or the outer carton. Additionally, for multi-dose bottles, the solution must be discarded within 28 days or one month after opening, even if the printed expiration date is later.


Q: Can Acular be used while breastfeeding or during pregnancy?

The use of Acular during late pregnancy (the third trimester) is generally advised to be avoided due to the known effects of prostaglandin-inhibiting drugs on the developing fetal heart. For breastfeeding, it is not known if the drug is passed into human milk when given topically, and caution is advised.


Q: Are there any common vision changes people report while on Acular?

In addition to temporary blurry vision immediately after instillation, official adverse reaction reports include other vision-related events. These can include less frequent occurrences of corneal edema (swelling of the cornea) or iritis, both of which can affect vision.

How should Acular be stored and disposed of?

How to Store and Dispose of Acular (Ketorolac Tromethamine Ophthalmic Solution)

Acular must be stored according to specific regulatory requirements to maintain its stability. The product should be stored at Controlled Room Temperature, typically 20 C to 25 C (68 F to 77 F), or below 25 C in some regions. It is mandatory to keep the product from freezing and out of the sight and reach of children.

Handling and Stability

The container must be kept tightly closed and protected from light. For multi-dose bottles, the solution must be discarded within mathbf28 mathbfdays or mathbfone mathbfmonth after opening, depending on the formulation. Single-use vials must be discarded immediately after use.

Disposal

Do not dispose of Acular via household waste or wastewater. Unused or expired medication must be disposed of in accordance with local regulations and by consulting a pharmacist.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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