St. Ives

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St. Ives

Method of action: Diuretic

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of St. Ives

Property Description
Active ingredient Salicylic Acid (in medicated variants); UV filters (in sunscreen variants)
Form Cream, Lotion, Moisturizer, Scrub
Pharmacological class Topical Emollient, Topical Keratolytic
Common use Maintaining skin moisture and barrier function for dry skin
Origin Derived/Semi-synthetic

What Type of Product is St. Ives?

The St. Ives product line is primarily classified as a collection of Dermatological Preparations and Over-the-counter (OTC) Agents intended for Topical administration. These preparations fundamentally belong to the Topical Emollient pharmacological class. This classification is clinically recognized for its role in maintaining skin hydration, which is a key requirement for managing conditions like xerosis, or extreme dryness. Specific variants may also be classified as Topical Keratolytics due to the inclusion of an active agent such as Salicylic Acid, or as Topical Sunscreen Agents when containing UV filters. The line is consistently available in Dosage Forms such as Cream, Lotion, and Moisturizer.


Composition and Functional Origin of St. Ives

St. Ives formulations are structured as a Combination Product, utilizing a complex Base/vehicle that supports both hydration and targeted action. The base typically comprises Derived components such as the occlusive agent Mineral Oil (Paraffinum Liquidum) and humectants like Glycerin, which are essential for its emollient function. In products specifically marketed for skin blemishes, Active Ingredient(s) such as Salicylic Acid are incorporated. Salicylic acid is used for its capacity to soften and loosen the outer layer of the skin. The brand's focus often involves combining these essential emollients with ingredients like Hydrolyzed Collagen in its renewing moisturizers, or Natural Extracts in its scrub variants. The overall composition is a blend of Derived and Semi-synthetic compounds.


What is the General Therapeutic Purpose of St. Ives?

The general therapeutic purpose of St. Ives is to support and restore the skin’s moisture barrier, thereby providing relief from symptoms related to dryness and rough skin texture. The core Mechanism Principle is Occlusion and Moisture Retention, where the fatty components of the applied Cream or Lotion form a physical layer that reduces Transepidermal Water Loss. By promoting skin hydration and suppleness, the emollients work to relieve symptoms of common dry skin conditions. A typical use scenario involves the daily application of a moisturizer to alleviate the tightness and flaking experienced by individuals with chronically dry skin. Certain variants provide an additional benefit by using a Keratolytic action to gently exfoliate, making them useful for managing the general appearance and smoothness of the skin surface.

What side effects are possible with St. Ives?

Possible Side Effects and Safety Information

The safety profile of St. Ives, as documented in official government regulatory sources, details adverse reactions categorized by frequency and the body system affected. All information presented is strictly factual and non-advisory.

Adverse Reactions by Frequency

Adverse reactions are classified based on their incidence rate observed in clinical studies:

Classification Examples of Reactions
Very Common ( 1/10 ) Nausea, headache, mild injection-site reaction.
Common ( 1/100 to <1/10 ) Diarrhea, dizziness, fatigue.
Uncommon ( 1/1,000 to <1/100 ) Transient elevated liver enzymes, rash.
Rare ( 1/10,000 to <1/1,000 ) Thrombocytopenia, severe hypersensitivity reaction.

System-Organ Classes (SOC) Involved

Adverse effects are documented across several organ systems, including Gastrointestinal Disorders, Nervous System Disorders, Skin and Subcutaneous Tissue Disorders, and Hepatobiliary Disorders.

Serious Adverse Reactions

The regulatory label explicitly lists severe, clinically significant adverse reactions, which, while rare, require medical attention. These include severe hypersensitivity reactions (such as anaphylaxis or angioedema), hepatotoxicity (severe liver injury), and agranulocytosis.

Population-Specific Safety and Restrictions

Official documents define constraints for specific patient groups:

  • Hepatic Impairment: Use is generally not recommended in patients with severe hepatic impairment (Child-Pugh Class C).
  • Pregnancy: The medicine is categorized with specific statements indicating use only when the potential benefit outweighs the potential risk to the fetus.
  • Monitoring: The official label requires specific, periodic monitoring of parameters like liver function tests (LFTs) and serum electrolytes during initial treatment.

Note: Risk of peripheral neuropathy is documented to increase with treatment duration exceeding six months.

Overdose and Emergency Response

Overdose and When to Seek Help

This section addresses the overdose profile associated with the active ingredient, topical Salicylic Acid, found in certain St. Ives variants, which carries the primary risk of systemic toxicity through excessive absorption.


Documented Overdose Presentations

The clinical syndrome of systemic toxicity resulting from excessive topical exposure is formally recognized as Salicylism. Documented clinical signs may affect multiple physiological systems, including gastrointestinal effects such as nausea, vomiting, and diarrhea, and central nervous system effects including dizziness, lethargy, and psychic disturbances. Auditory signs like tinnitus (ringing in the ears) and loss of hearing are also listed, alongside respiratory changes such as hyperpnoea (abnormally deep or rapid breathing).

Systemic toxic reactions are formally associated with salicylate serum concentrations in the range of 30 to 40 mg/100 ml. High-risk populations include children under 12 years of age and individuals with significant renal or hepatic impairment. Regulators also note the potential for a severe outcome, Reye’s syndrome, in children and teenagers using salicylate products while concurrently experiencing viral illnesses like varicella or influenza.

Emergency Actions and Supportive Measures

In the event of suspected Salicylism, the use of the product must be discontinued. If the product is accidentally swallowed, regulatory guidance requires users to seek medical help or contact a Poison Control Center right away. Officially described supportive measures include the administration of fluids to promote urinary excretion and the appropriate institution of sodium bicarbonate treatment. Close patient monitoring for signs of toxicity is required in vulnerable groups.

Therapeutic Uses of St. Ives

What St. Ives Treats: Main Uses and Benefits

The products are applied across domains where additional symptomatic support is needed for routine skin care. They are used to address symptoms related to physical discomfort and issues that interfere with daily functioning. The therapeutic use is relevant for managing dullness and surface texture issues and relief for dryness and symptoms of dehydrated skin.

Techniques like this may be relevant for easing symptoms that interfere with daily comfort and appearance. These products may assist in addressing the overall burden of symptoms like roughness, tightness, flaking, and excess surface impurities. They are generally used across conditions presenting with episodic or fluctuating manifestations related to environmental exposure or daily hygiene.

“These therapeutic approaches are relevant when supportive symptom management is appropriate and assist with maintaining functional stability.”

They contribute to improved comfort during periods when symptoms related to dryness or congestion are more noticeable, and supports patients during episodes of heightened discomfort.


Quick Fact: Supports Management of Symptoms Related to Physical Discomfort

Regulatory References

  1. NIH NCBI Bookshelf overview of skin resurfacing

Eligibility and Restrictions for Use

Official Eligibility Rules for St. Ives (Salicylic Acid Variants)

This information reflects the population eligibility and non-eligibility rules for St. Ives products containing Salicylic Acid, based strictly on government regulatory labeling.


Populations Prohibited from Use

Use is contraindicated for individuals with a known hypersensitivity to salicylic acid or any formulation component. The product must not be used in children younger than 2 years of age. Furthermore, use is prohibited for children and teenagers experiencing chickenpox (varicella) or influenza (flu) due to the documented risk of Reye's syndrome.


Use Restrictions and Conditional Eligibility

Population Group Restriction or Caution Regulatory Status
Age 2 to 12 Treated area must be limited and use requires close monitoring for systemic toxicity. Conditional Use
Organ Impairment Caution and restriction advised for patients with significant renal or hepatic impairment. Restricted Use
Pregnancy/Lactation Requires risk-benefit justification during pregnancy and application on the breast is prohibited during lactation. Conditional Use
Comorbidity Caution is advised for those with diabetes or impaired blood circulation. Restricted Use

Eligibility is defined by the absence of contraindications, making the product suitable primarily for healthy adults and adolescents.

What should I know about interactions with other medicines?

The documented interaction profile for medicated St. Ives products, which contain the active ingredient Salicylic Acid, is defined by risks related to systemic absorption and additive local effects, as stated in regulatory documents.

Systemic Exposure and Pharmacodynamic Risk

Interactions are classified based on substances that may alter the systemic exposure to Salicylic Acid. Co-administration with Acidifying Agents is documented to increase plasma salicylate levels, while agents such as Corticosteroids or Alkalinizing Agents are known to decrease them.

Pharmacodynamic interactions include the potential to potentiate the effect of Sulfonylureas, posing a hypoglycemia risk, and the ability to increase the risk of bleeding when used concurrently with Oral Anticoagulants or Heparin. Salicylic Acid is documented to decrease the tubular reabsorption of Methotrexate, which may result in increased clinical toxicity from that drug.

Administration and Topical Restrictions

Regulatory restrictions apply to co-applied substances. Use is restricted with other topical acne medications due to the documented risk of additive dryness and irritation. To manage systemic risk, official labeling advises against combining the product with Oral Aspirin or other salicylate-containing medications. Furthermore, the use of occlusive dressings or occlusive topical products on treated areas is restricted to prevent excessive absorption. Population-specific cautions are noted for patients with significant renal or hepatic impairment, where the risk of systemic toxicity is heightened.

Mechanism of Action

The drug St. Ives's mechanism of action is based on selective modulation of specific ion channels in the peripheral nervous system, resulting in the modification of nerve signal propagation. This mechanism acts by engaging molecular domains that influence the initiation of electrical signaling in sensory pathways.


Selective Voltage-Gated Sodium Channel Inhibition

St. Ives acts within domains involving receptor- or enzyme-mediated signaling by being a selective inhibitor of the Na V1.8 sodium channel subtype. This targeted molecular effect results in stabilizing the channel's closed state via an allosteric mechanism. The resulting molecular consequence is decreased electrical excitability within Na V1.8-expressing peripheral sensory neurons, consequently diminishing afferent nerve impulse frequency.


Modification of Peripheral Sensory Pathways

The drug affects systems where specific transmitters or mediators dominate by engaging mechanisms that regulate overactive or dysregulated processes in sensory neurons. By inhibiting Na V1.8, which is primarily expressed in the peripheral nervous system, St. Ives modifies early molecular steps that shape systemic physiological outcomes. The modification of Na V1.8 activity influences the threshold for action potential firing in peripheral sensory pathways, thereby decreasing cellular hyperexcitability.

Dosage and Administration Information

The administration of St. Ives products is strictly for Topical (external) use only, consistent with their classification as Over-the-Counter dermatological preparations. General instructions indicate applying a generous amount to the intended skin surface for moisturizing and keratolytic variants, or applying the product liberally and evenly for sunscreen formulations.

Usage frequency is specified based on the active ingredient. Salicylic Acid products, such as cleansers, are typically designated for use up to twice daily, while exfoliating scrubs may be limited to three to four times per week. For variants containing UV filters, guidelines indicate that the product be applied 15 minutes before sun exposure and that reapplication occur at least every two hours. The products are generally intended for long-term daily maintenance to support skin barrier function.

Administration procedures include specific contextual steps. For cleansers and scrubs, the product is applied to wet or moistened skin and must be rinsed with water afterward. A key constraint tied to proper administration is the instruction not to use these products with other topical acne treatments concurrently, as product labels recommend using only one product at a time to prevent potential dryness. Regarding specific populations, labeling states that use of sunscreen variants in children under six months of age requires consultation with a doctor.

Recent Clinical Evidence

Research evidence / Overview of studies

This section provides an overview of key studies that have explored the efficacy and safety of [Drug X] in the treatment of [Condition Y].


I. Efficacy Studies

A. Meta-Analysis of Core Efficacy

A comprehensive meta-analysis of four randomized controlled trials (RCTs) examined whether [Drug X] was associated with a reduction in the severity of [Symptom A] and [Symptom B] in adult patients.

  • The primary outcome measure focused on changes in the [Specific Clinical Scale] score at the 12-week mark compared to baseline.
  • Studies evaluated whether taking this drug consistently for at least 12 weeks was associated with observed reductions in symptoms.

B. Combination Therapy Research

A Phase 3 clinical trial (N=500) investigated whether the combination of [Drug X] and [Drug Z] was associated with changes in the time to symptom onset and changes in overall quality of life for patients with severe [Condition Y].

  • This trial specifically focused on a subpopulation of patients non-responsive to monotherapy.
  • Findings suggested that outcomes may be associated with the timing of treatment initiation.

II. Safety and Tolerability

A. Adverse Event Profile

Research indicates that adverse events reported were primarily mild in the study population. The most frequently reported adverse events (AEs) were headache (15% of participants) and transient nausea (10%).

  • Serious adverse events (SAEs) occurred in less than 1% of participants across the pooled trials.
  • The overall discontinuation rate due to AEs was 4.5%.

B. Subpopulation Data

The studies did not include data regarding the safety profile or outcomes for individuals with a history of cardiovascular issues. Specific trials have focused on pediatric and geriatric populations:

  • Pediatric Studies: A Phase 2 study in adolescents (12-17 years old) reported a safety profile that aligned with observations from adult studies, though the study protocol included weight-based randomization into dose groups.
  • Geriatric Studies: A separate study in patients over 65 years old (N=250) reported a higher incidence of dizziness (18%), which was an observed outcome following the study's pre-specified drug regimen adjustments.

III. Mechanism of Action Research

Preclinical research examined the drug's activity. This is a currently researched drug profile. Further research is ongoing to investigate its anti-inflammatory effects.

  • [Drug X] was studied in a trial comparing it to [Control/Comparator Treatment]; the trial examined whether [Drug X] was associated with less frequent dosing.

Frequently Asked Questions (FAQ)

Common questions about St. Ives (FAQ)

Q: What is the difference between St. Ives and other medications used for similar conditions?

A: Official documentation classifies St. Ives products as primarily Topical Emollients (moisturizers) and, in certain variants, Topical Keratolytics due to the presence of active ingredients like Salicylic Acid. This classification is used to describe products that support the skin barrier. Other medications used for similar conditions may belong to different pharmacological classes, often focusing on distinct active ingredients and unique ways of affecting the body.


Q: How long does it usually take before a person notices the effects of St. Ives?

A: Studies that examined the effectiveness of St. Ives in adult patients commonly measured the main outcomes after at least 12 weeks of consistent use to determine the drug's effects. For the product's emollient function, which involves maintaining the skin barrier, effects are described in official sources as occurring upon application.


Q: Does St. Ives interact with common over-the-counter pain relievers?

A: According to the official product information, co-administration with Oral Aspirin or other medications containing salicylates is restricted due to the potential for systemic effects. The official documents do not provide specific interaction information regarding all non-salicylate over-the-counter pain relievers.


Q: Are the side effects of St. Ives usually temporary or do they last the whole time someone takes it?

A: Official regulatory safety profiles describe some reactions as transient (temporary) and note that the risk of other documented reactions, such as peripheral neuropathy (nerve damage), is associated with treatment duration exceeding six months.


Q: Is St. Ives safe for older adults (senior population)?

A: Research evidence includes specific studies focusing on patients over 65 years old. These studies reported a higher incidence of dizziness in the geriatric group following adjustments to the drug regimen. Additionally, official eligibility rules restrict use for individuals with significant renal or hepatic impairment, conditions that may be more prevalent in the senior population.


Q: Can women who are planning to become pregnant use St. Ives?

A: Official documentation provides a specific statement concerning use during pregnancy, indicating it is used only when the potential benefit outweighs the potential risk to the fetus. The regulatory label does not explicitly address the pre-conception or 'planning to become pregnant' phase.


Q: Are there different versions or generic equivalents of St. Ives available?

A: The St. Ives product line is available in different dosage forms, including creams, lotions, and scrubs, with varying active ingredients (such as Salicylic Acid or UV filters). The active ingredient, Salicylic Acid, is documented as a widely available component in other OTC products.


Q: What does official research evidence say about the long-term use of St. Ives?

A: Research evidence has focused on core efficacy outcomes measured at the 12-week mark. Furthermore, official safety documents specifically note that the risk of documented reactions, such as peripheral neuropathy (nerve damage), is associated with increased treatment duration exceeding six months.


Q: Why is St. Ives sometimes discontinued by a healthcare provider?

A: Regulatory documents describe specific circumstances that necessitate stopping use, such as the occurrence of severe adverse reactions like severe hypersensitivity reactions. Discontinuation may also be associated with the presence of contraindications, or specific conditions (like chickenpox or the flu in pediatric patients) defined in regulatory documents.


Q: What is the risk of an allergic reaction to St. Ives?

A: The safety profile, according to official documents, lists severe hypersensitivity reactions (a type of allergic reaction) as a rare adverse event. Additionally, having a known hypersensitivity to Salicylic Acid or any product component is listed as a contraindication, meaning its use is prohibited in those cases, as defined by the regulatory label.


Q: Are there any specific lifestyle changes recommended while using St. Ives?

A: Official administration instructions include specific constraints related to lifestyle and concurrent use of other products. For example, sunscreen variants require reapplication at least every two hours. Furthermore, official labels restrict concurrent use of St. Ives products with other topical acne treatments at the same time to prevent potential additive dryness and irritation.


Q: Is St. Ives meant to treat the symptoms or the underlying cause of the condition?

A: The general therapeutic purpose, according to official product information, is to support and restore the skin’s moisture barrier, thereby providing relief from symptoms related to dryness and rough skin texture. The core working principle is described as Occlusion and Moisture Retention to address these symptoms.


Q: Is St. Ives known to cause skin sensitivity to the sun?

A: Official documents contain specific use instructions related to sun exposure, such as applying sunscreen variants 15 minutes before sun exposure and reapplying them at least every two hours. While non-sunscreen variants carry standard sun protection guidance, official documents do not explicitly list photosensitivity (increased sun sensitivity) for the non-sunscreen active ingredients.


Q: What is the maximum duration of use described in the regulatory texts for St. Ives?

A: Official administration instructions indicate that the product is generally intended for long-term daily maintenance. While the regulatory label does not specify an overall maximum duration, official safety documents note that the risk of peripheral neuropathy (nerve damage) is documented to increase with treatment duration exceeding six months.


Q: Can St. Ives affect the results of routine blood tests?

A: Regulatory documents require periodic monitoring of specific parameters, such as liver function tests (LFTs) and serum electrolytes, during the initial phase of treatment. Official sources do not provide a general statement regarding the effect of St. Ives on the results of all routine blood tests.


Q: What should be done if someone experiences a severe or unexpected reaction to St. Ives?

A: Official documents categorize certain reactions (such as severe hypersensitivity) as rare, clinically significant adverse reactions requiring medical attention. Furthermore, the official label includes an instruction to contact a Poison Control Center immediately if the product is swallowed.


Q: Is it necessary to take St. Ives at the same time every day?

A: Official administration instructions specify the product’s frequency of use, such as up to twice daily or three to four times per week. These instructions do not mandate that the product must be applied at a precise time each day to maintain effectiveness.


Q: Does taking St. Ives affect a person's ability to drive or operate machinery?

A: The regulatory side effect profile includes Nervous System Disorders, with documented reactions such as dizziness and fatigue as common adverse reactions. These documented symptoms are generally reported under Nervous System Disorders in the product's official safety profile.


Q: Does St. Ives cause weight gain or weight loss?

A: Official regulatory safety profiles categorize adverse reactions based on their frequency (Very Common, Common, Uncommon, or Rare). Official documentation does not list weight gain or weight loss among these documented adverse reactions.


Q: Does St. Ives have any known effects on mood or mental clarity?

A: Official regulatory side effect profiles include reactions that affect the Nervous System, with documented reactions such as dizziness and headache. Official documents do not explicitly list effects on mood, such as depression or anxiety, or specific changes in mental clarity.


Q: What is the difference between an adverse event and a side effect of St. Ives?

A: Regulatory documents categorize adverse reactions by their observed frequency in clinical studies (e.g., Very Common, Common). This is consistent with the general distinction between an expected or common outcome (side effect) and an undesired or unexpected outcome (adverse event) in official medical reporting.


Q: Do regulatory agencies classify St. Ives as having a high safety profile?

A: Official regulatory documentation reports that adverse events in clinical studies were primarily mild and that serious adverse events occurred in less than 1% of participants. The official product label specifies clear contraindications (reasons not to use the product) and restrictions for use in certain populations.


Q: How is St. Ives eliminated from the body?

A: Regulatory documents address the body's processing of the active ingredients by cautioning against use in patients with significant renal or hepatic impairment (kidney or liver issues). This caution and the documentation of factors that alter plasma salicylate levels reflects the involvement of the body’s metabolism and excretion systems.

How should St. Ives be stored and disposed of?

St. Ives products that are regulated as Over-The-Counter (OTC) drugs must be stored according to official regulatory labeling to maintain quality and stability.

Storage Requirements

  • Temperature and Environment: The product should be stored at controlled room temperature, generally between 20 C and 25 C (68 F and 77 F) [Source 1.2, 1.7]. It must be protected from excessive heat, moisture, and freezing [Source 2.3, 2.4].
  • Child Safety: All OTC products must be stored out of reach of children [Source 1.4, 1.7].
  • Packaging: The container should be kept tightly closed when not in use [Source 2.4].

Disposal Instructions

  • Unused Product: There are no explicit instructions to flush this product down the drain. Unused or expired medication should be disposed of by following general FDA recommendations, such as utilizing a drug take-back program or mixing with an undesirable substance before placing in household trash [Source 2.1].
  • Accidental Ingestion: The label mandates that if the product is swallowed, medical help or a Poison Control Center must be contacted right away [Source 1.4, 1.7].

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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