Эфизол

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Эфизол

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Эфизол

Quick Facts

Property Description
Active ingredients Dequalinium Chloride, Sodium Ascorbate
Form Lozenges (Pastilles)
Pharmacological class Local Anti-infective, Oropharyngeal Antiseptic
Common purpose Managing symptoms and microbial load in mouth/throat
Origin Synthetic Compound

What Type of Medicine is Эфизол?

Эфизол (Efizol) is classified as a Combined Drug and Stomatological Preparation, supplied in the Dosage Form of Lozenges designed for Oral Administration via Local Application. Pharmacologically, it is categorized as a Local Anti-infective and Oropharyngeal Antiseptic. Its primary active agent, Dequalinium Chloride, is formally classified as an Anti-Infective Agent, Local, a property that is recognized for providing focused action against pathogens in the oropharyngeal area. The convenience of the lozenge form, dissolving slowly in the mouth, is a differentiating factor that ensures sustained drug delivery compared to liquid rinses, maximizing local contact time.

What are the Active Ingredients in Эфизол?

The medication contains two distinct Active ingredients: the primary Antiseptic, Dequalinium Chloride, and Sodium Ascorbate. Dequalinium Chloride is a Synthetic Compound belonging to the Quaternary Ammonium Compound (QAC) class, which works to exert a powerful Bactericidal Effect and Fungicidal Effect through physical Membrane Disruption. The secondary component, Sodium Ascorbate, is a form of Ascorbic Acid (Vitamin C) that is recognized for its Antioxidant Effect. The antioxidant properties of Ascorbic Acid are associated with supporting the body's natural defense and repair mechanisms in local tissues, providing a composition feature unique to this preparation.

What is the General Purpose of Эфизол?

The general purpose of Эфизол is to deliver sustained Antimicrobial Action directly to the lining of the oropharynx via Local Application from the dissolving lozenge. This targeted approach is intended for reducing the microbial population that contributes to the discomfort and symptoms associated with Oropharyngeal Infections. By leveraging its potent Antiseptic properties, the product aims to reduce the load of infectious agents, supporting the local environment against the proliferation of microorganisms.

What side effects are possible with Эфизол?

Possible Side Effects and Safety Information

The safety profile of Эфизол (Dequalinium Chloride, Sodium Ascorbate lozenges) is characterized by a low incidence of adverse reactions, as documented in official regulatory summaries. The most commonly noted effects are primarily localized to the area of application, consistent with its function as a topical oropharyngeal antiseptic.

Official Adverse Reactions and Frequency

Adverse reactions listed in regulatory documents are generally classified as Rare, meaning they occur at a very low frequency across the patient population (ge 1/10,000 to < 1/1,000). These include:

Classification Affected System-Organ Class Specific Reactions
Rare Gastrointestinal / Administration Site Local Irritation, Stomatitis (inflammation of the mouth)
Rare Skin and Subcutaneous Tissue Rash, Pruritus (itching)
Rare Immune System Disorders Hypersensitivity Reactions

Hypersensitivity Reactions are considered the most clinically significant type of adverse reaction documented, though still classified as rare.


Population-Specific Safety Considerations

Official labeling addresses specific population constraints based on available data:

  • Pregnancy and Lactation: The safety of the active ingredients during these periods has not been definitively established. Use requires a careful, documented assessment of the potential benefits versus the risks.
  • Older Adults: No specific dosage reduction is explicitly deemed necessary for use in the elderly population.

Safety-Related Restrictions

The most important safety limitation defined in official prescribing information is the strict Contraindication for use in individuals with a known Hypersensitivity to Dequalinium Chloride, Sodium Ascorbate, or any other components (excipients) in the lozenge. The regulatory profile indicates that overdosage is not expected to present a serious issue beyond possible mild gastrointestinal discomfort.

Overdose and Emergency Response

Overdose and when to seek help for Эфизол

Official regulatory documents state that specific clinical data concerning an overdose with the lozenge product, Эфизол, are not available. Overdose scenarios are instead based on the known systemic effects of the individual active components. Regulators mandate that immediate medical attention must be sought if any adverse symptoms are experienced after taking more than the officially recommended dose.

Manifestations of exceeding the dose may involve signs related to the local antiseptic, which primarily include gastrointestinal discomfort. Systemic intake of high amounts of the Sodium Ascorbate component may present with common systemic symptoms such as nausea, vomiting, indigestion, diarrhea, headache, fatigue, and disturbed sleep. The required clinical approach for managing an overdose is officially defined as symptomatic treatment.

Of particular note are the documented severe outcomes associated with the Ascorbate component. The potential for oxalate stone formation in the kidneys is a recognized risk linked to chronic, excessive use. Furthermore, a specific population risk exists: individuals with Glucose-6-phosphate dehydrogenase (G6PD) deficiency are documented to face an increased risk of severe hemolysis following high-dose exposure to the Ascorbic Acid component. These population-specific risks and the required immediate action define the overall official regulatory overdose profile.

Therapeutic Uses of Эфизол

The active agent is indicated for use in situations involving certain distressing symptoms related to infections and inflammation of the mouth and throat.

This medicine is generally used for the symptomatic management of acute, localized infections of the oropharynx, including common conditions like pharyngitis, tonsillitis, and stomatitis. The therapeutic benefit is focused on addressing symptom clusters that may become intense or disruptive and are associated with irritation and localized lesions. The medication may assist with easing symptoms related to physical discomfort, such as acute sore throat pain, discomfort stemming from inflamed tissues, minor breaks in the mouth lining, such as aphthous ulcers and glossitis, and specific infective ailments like oral candidiasis (thrush). This relief contributes to improved day-to-day comfort during periods when speaking and swallowing are difficult.

The medication is considered relevant in clinical settings marked by the discomfort of specific oral infective ailments.

This supportive role may help patients cope with difficult episodic or recurrent symptom patterns, providing support that helps ease the overall symptom burden.

Quick Fact: Supportive Relief for Pain and Discomfort
Symptom focus Symptoms related to acute sore throat, oral irritation, and inflammation
Use context Seasonal or acute localized infections (e.g., pharyngitis, stomatitis)
Primary benefit Contributes to improved comfort and eases overall symptom load

Eligibility and Restrictions for Use

Who can and cannot use Эфизол?

Eligibility for Эфизол (Dequalinium Chloride and Sodium Ascorbate lozenges) is strictly defined by regulatory warnings and contraindications related to hypersensitivity, age, and reproductive status, as documented in official prescribing information.

Contraindicated Populations
Individuals with known hypersensitivity to Dequalinium Chloride, Sodium Ascorbate, or any of the excipients.
Children under 4 years old, due to the physical risk of the lozenge falling into the airways (choking hazard).

Age-Related Eligibility

The medicine is contraindicated for children under four years old. Use is permitted for children from 4 to 10 years old only under a conditional restriction requiring a specific, modified administration method. Adults and children over 10 years old are permitted to use the medicine under standard labeled conditions. Use is generally permitted for older adults without required dosage reduction.

Special Population Status

Safety has not been established for use in pregnant women or breastfeeding women, according to regulatory documentation. No explicit restrictions are documented based on the status of renal impairment or hepatic impairment.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory documents for Эфизол (which contains Dequalinium chloride and Ascorbic acid) define the product's interaction profile primarily through the absence of dedicated studies. The label explicitly states that no formal investigations into potential interactions with other medicinal products have been performed to date.

Documented Interaction Profile

Because dedicated clinical interaction studies are currently unavailable, the official regulatory information does not list specific interacting medicines, product classes, or dietary substances that require modification or avoidance.

This means the regulatory documents do not contain explicit statements regarding:

  • Specific Interacting Medicines: No individual prescription or over-the-counter medicines are explicitly listed for required caution or contraindication.
  • Timing Constraints: No rules are provided for spacing the administration of Эфизол relative to other medications.
  • Mechanistic Basis: There are no documented statements describing pharmacokinetic (e.g., enzyme inhibition/induction) or pharmacodynamic interaction mechanisms.
  • Interaction-Related Restrictions: No procedural or condition-specific restrictions are defined based on concurrent product use.

The regulatory structure emphasizes that the formal interactions section is empty due to the lack of clinical data on co-administration risks, rather than proof of their absence. Consequently, the official labeling provides no classifications regarding the severity or clinical relevance of potential interactions.

Mechanism of Action

The mechanism of action for Эфизол is based on the complementary, localized dual-action of its two active components, engaging two distinct mechanistic pathways: microbial eradication and local vascular modulation.

Anti-Infective Mechanism: Microbial Cell Integrity Disruption

This domain covers the action of Dequalinium Chloride, a quaternary ammonium compound. Its function involves a non-selective biophysical interaction that rapidly targets and disrupts the cell membranes of both bacteria and fungi, inhibiting essential microbial enzymes and leading directly to microbial cell death. This mechanism acts to reduce the concentration of pathogenic microorganisms at the site of application.

Supportive Mechanism: Local Vascular and Oxidative Stress Modulation

The secondary mechanism involves Sodium Ascorbate, which acts to stabilize the integrity of the microcapillary endothelial barrier. This action limits fluid extravasation, thereby reducing localized fluid accumulation (edema). Additionally, its antioxidant properties neutralize the reactive oxygen species produced by local inflammation, further contributing to the maintenance of mucosal barrier integrity.

Dosage and Administration Information

Administration Protocol

The lozenge form of Эфизол (Dequalinium Chloride/Sodium Ascorbate) is intended for administration via the oral route for local application within the oropharynx. The product is designed to be sucked slowly in the mouth and not chewed or swallowed whole; this method is utilized to ensure sustained contact of the active components with the lining of the throat and mouth.


Dosing and Schedule

The standard dosing regimen for adults and children over 10 years of age specifies the use of one lozenge every two to three hours. Administration is limited by a maximum, which should not exceed 8 to 10 lozenges within any 24-hour period. For children between the ages of 4 and 10 years, the dose is half (1/2) a lozenge per administration, with the maximum daily intake constrained to 4 to 5 lozenges. The product is not suitable for children under 4 years due to administration risks associated with the dosage form.


Procedural Constraints and Duration

To maintain the local concentration of the antiseptic agent, the protocol involves abstaining from consuming any food or liquids for 30 minutes following the use of the lozenge. The total treatment course is duration-limited; use should generally not exceed 5 to 7 days. Use may be continued for one to two days after the initial discomfort has subsided, provided it adheres to the overall maximum course length. This describes the standardized use of the medicine.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Эфизол


Evidence for Acute Throat and Tonsil Infections (Pharyngitis/Tonsillitis)

Studies relevant to the use of Эфизол have been conducted during periods of increased symptom activity in the throat and tonsils. Research has primarily explored the lozenge form containing the main antiseptic component, Dequalinium Chloride. The available research includes short-term Randomized Controlled Trials (RCTs), where the agent was compared with a non-active substitute (placebo) to monitor the change in symptoms in the study groups. Researchers typically included patients with infections that were not confirmed to be caused by specific bacteria like Streptococcus, making the evidence relevant in trials assessing short-term or episodic symptom patterns common to viral or unspecified causes.

The studies examined outcomes related to physical discomfort, tracking how patients reported the intensity of pain, such as sore throat pain and difficulty swallowing. In these trials, research also monitored local clinical markers, such as the appearance of the tonsils, and sometimes tracked bacteriological findings to monitor how the presence of microbes varied during the study period. Studies reported measurements of changes in symptoms over the short-term course of the illness. In general, research highlights that studies monitored outcomes suggesting a localized pattern of change in the oropharyngeal area.

Research on Local Oral Lesions (Stomatitis, Aphthous Ulcers, and Glossitis)

Evidence concerning the use of the preparation for discomfort related to minor mouth lesions, such as canker sores (aphthous ulcers) or inflammation of the mouth (stomatitis), is largely derived from smaller clinical trials and general clinical observation. The research explored how symptoms changed in conditions characterized by fluctuating or episodic manifestations of mucosal disruption in the mouth lining. In these contexts, the studies examined outcomes related to physical discomfort, specifically tracking how patients reported pain and monitoring the duration until lesions showed a change in status. Findings from these studies report how symptoms evolved in the observed populations over defined, short-term intervals of high symptom activity.


Understanding the Research Gaps and Uncertainty

The overall evidence base for Эфизол describes several areas where certainty remains low. One key gap is the limited number of large-scale, recent comparative studies that fully evaluate the combined effect of both active components, Dequalinium Chloride and Sodium Ascorbate, in the lozenge against a placebo. While studies have explored the single antiseptic component, comparative evidence is lacking for the specific dual-component product in large adult populations.

Furthermore, the evidence quality varies across studies, particularly for the indications involving local oral lesions. Because sample sizes were modest and follow-up durations were short in many studies, the existing data provides insight into short-term changes in outcomes describing episodic or acute changes, rather than providing comprehensive long-term predictions. Research so far contributes to understanding symptom patterns but does not determine whether an individual will respond similarly.

Key Studies & References

  1. Dequalinium Lozenges - SingHealth (Information on uses, side effects, and administration of lozenges)
  2. dequalinium | Dosing & Uses - medtigo (General drug information, including non-oral uses and administration)

Frequently Asked Questions (FAQ)

Common questions about Эфизол (FAQ)


Q: Can Эфизол be used for a sore throat that is not caused by bacteria?

Studies and official product information indicate that the active ingredient is an antiseptic with activity against a range of microorganisms. This includes not only bacteria but also yeasts and fungi. This broad spectrum activity is a component of its classification as an antiseptic for various infections of the mouth and throat.


Q: Is it normal to feel a strange taste in my mouth after using Эфизол?

A strange or unpleasant taste is not explicitly listed in official adverse reaction documents. However, occasional undesirable effects such as soreness of the tongue and general mouth discomfort are listed. If symptoms are experienced, information should be sought from a healthcare professional.


Q: Does Эфизол interact with common pain relievers like paracetamol or ibuprofen?

According to the official product information, no clinically significant drug interactions are known with other medications, including common pain relievers. The regulatory documents also note that no formal interaction studies have been performed to date to investigate this.


Q: Can I use Эфизол if I am also taking vitamins or herbal supplements?

Official regulatory documents do not list any known clinically significant interactions with other medicinal products or dietary substances, such as vitamins or herbal supplements. The full list of products being used can be discussed with a healthcare provider.


Q: Is Эфизол a prescription-only medicine?

This type of medication, an oral antiseptic lozenge, is generally classified in many regions as an Over-the-counter (OTC) medicine. This means it is available for purchase without a doctor’s prescription.


Q: What happens if I miss using a dose of Эфизол?

If a lozenge dose is missed, regulatory guidance advises against taking a double dose to compensate. The guidance is to resume the scheduled routine at the next planned time.


Q: Is Эфизол effective for fungal infections in the mouth or throat?

The pharmacological properties of the active ingredient indicate activity against various microorganisms, including yeasts and fungi. This activity is a component of its classification as an antiseptic for oral infections.


Q: Does Эфизол contain sugar, and is it safe for diabetics?

The official excipient list confirms that the standard lozenge formulation contains both sucrose and liquid glucose. This information is intended for consideration by individuals with diabetes or those who monitor their sugar intake.


Q: Can Эфизол cause an allergic reaction, and what signs should I look for?

Hypersensitivity (allergic) reactions are possible, though they are listed as a rare undesirable effect in official documents. Severe signs of a drug allergy may include swelling of the face, tongue, or lips, or difficulty in breathing. This is also why hypersensitivity is a contraindication.


Q: What are the general expectations for the duration of its effect?

The expected duration of the medicine's local effect is reflected by the regulatory-approved re-dosing interval. This interval is typically set at every two to three hours.


Q: Can Эфизол be used by people with other chronic health conditions?

The official regulatory documents list specific contraindications, primarily hypersensitivity and age. The documents are silent on specific restrictions for conditions such as severe kidney or liver impairment, as these are not listed as contraindications. Assessment guidelines from a healthcare professional may be followed by individuals with chronic conditions.


Q: What are the signs that my symptoms are severe enough to see a doctor while using Эфизол?

Official warnings mention that seeking information from a healthcare professional is appropriate if symptoms continue or do not show signs of improvement while using the medication. This guidance is in place for any symptoms that persist despite treatment.


Q: Does the active ingredient in Эфизол enter the bloodstream?

The product is designed for localized action in the mouth and throat for its therapeutic effect. The official regulatory documents generally do not contain detailed data on the systemic pharmacokinetic properties, such as the amount absorbed into the bloodstream.


Q: Why is professional guidance mentioned for using Эфизол?

Professional guidance is primarily mentioned because the safety of the active ingredients has not been established for use during pregnancy or lactation. In these special populations, a healthcare professional must carefully assess the potential benefits versus the risks.


Q: Does Эфизол have a systemic effect?

The medicine is classified exclusively for local therapy of the mouth and oropharynx. The absence of systemic pharmacokinetic data means its regulatory classification focuses entirely on the targeted local effect.


Q: What does the official drug label say about how long the product can be stored?

The official regulatory documents define a specific shelf life for the unopened product, which is often three years from the date of manufacture. Use of the medicine is restricted after the expiry date printed on the packaging.


Q: Is it normal if my throat irritation gets worse immediately after using Эфизол?

Local irritation and soreness of the tongue are listed as possible, though rare, undesirable effects of the lozenge. Official warnings mention that seeking information from a healthcare professional is appropriate if local symptoms significantly worsen or persist.


Q: How is Эфизол eliminated or broken down by the body?

Detailed pharmacokinetic properties, such as how the components are eliminated or broken down by the body, are generally not included in the official regulatory summaries. This is common for products intended for purely local action.


Q: Does Эфизол contain any ingredients that might cause sensitivity in people with asthma?

Regulatory documents list all excipients, which may include colorants like Sunset Yellow (E110) or specific flavoring agents. The full excipient list is available for review by patients who have sensitivities, such as those with asthma, for discussion with a healthcare provider.


Q: Can Эфизол be used for mild infections only?

The official indication is for the local therapy of common infections of the mouth and oropharynx, such as pharyngitis and tonsillitis. The regulatory documentation does not define use based on the subjective severity of the infection.

How should Эфизол be stored and disposed of?

How to Store and Dispose of Эфизол?

The official labeled requirements define precise conditions for storing and discarding Эфизол lozenges.


Storage and Protection

Requirement Condition
Temperature Do not store above 25 C
Packaging Store in the original packaging
Protection Keep protected from moisture and light
Child Safety Keep out of the sight and reach of children

Disposal

The product must not be used after the expiry date printed on the carton. Any unused or expired Эфизол lozenges or associated waste materials must be disposed of in accordance with local regulatory requirements. The general instruction is to not throw away medicines via household waste or wastewater unless specifically authorized by local authorities.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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