Mag64

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Mag64

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Mag64

Mag64 is an Over-the-Counter (OTC) Combination Product that serves as a Mineral Supplement and Electrolyte Replenisher. It is an oral preparation designed to address nutritional requirements by providing two essential ionic compounds critical for metabolic health.

Property Description
Active ingredient Magnesium Chloride and Calcium Carbonate (INN)
Form Oral Delayed-Release Tablet
Pharmacological class Minerals and Electrolytes
Common use Dietary supplementation and mineral replenishment
Origin Derived from naturally occurring ionic compounds

1. Defining Mag64: Classification and Core Identity

This preparation is a combination medicine, formulated to deliver both Magnesium and Calcium simultaneously, differentiating it from single-ingredient supplements. As an electrolyte replenisher, its formulation is recognized for providing essential co-factors required for numerous biological processes. It is typically used when a diet is insufficient in these key minerals or when losses occur, such as those associated with high physical activity. Mag64 is one of several brands, alongside analogues like Slow-Mag, that utilize this specific combination and delivery system.

2. Composition, Source, and Delivery Form

The active components are the mineral salts Magnesium Chloride and Calcium Carbonate, which are sourced from naturally occurring ionic compounds. The distinct feature of this preparation is its form: the Oral Delayed-Release Tablet. The enteric coating ensures the tablet resists dissolution in the acidic stomach environment, releasing the mineral salts primarily in the small intestine. This controlled delivery aids in the efficient absorption and utilization of the highly soluble Magnesium Chloride Hexahydrate.

3. General Purpose of the Mineral Combination

The primary utility of Mag64 is the replenishment of elemental Calcium and Magnesium stores to support fundamental bodily functions. These minerals are recognized as tightly coupled elements playing key roles in maintaining metabolic balance. By restoring sufficient levels of these ions, the supplement assists in maintaining proper neuromuscular functioning and is essential for both muscle contraction and relaxation (including the heart rhythm) and for supporting healthy bone maintenance.

Regulatory References

  1. NIH Office of Dietary Supplements

What side effects are possible with Mag64?

Possible Side Effects and Safety Information

This section outlines the officially documented adverse effects and safety constraints for combination mineral supplements containing Magnesium Chloride and Calcium Carbonate, based strictly on government regulatory sources.


Documented Adverse Reactions

Adverse effects are primarily associated with the Gastrointestinal Disorders system-organ class and are often classified as Common in regulatory documents.

  • Common Side Effects: Diarrhea, Constipation, Upset stomach or stomach discomfort, Nausea, and Vomiting.

Serious Adverse Reactions and Systemic Imbalance

Serious adverse reactions are typically linked to mineral accumulation or toxicity, requiring caution and monitoring:

System-Organ Class Serious Adverse Reaction Note
Metabolism/Nutrition Hypercalcemia (high calcium) Risk associated with high-dose, long-term use.
Metabolism/Nutrition Hypermagnesemia (high magnesium) Risk increased in patients with impaired kidney function.
Nervous System Confusion, Drowsiness Potential signs of severe mineral imbalance.
Cardiac Disorders Bradycardia (slow heart rate) Symptom of severe magnesium imbalance.

Safety Constraints and Special Populations

Official labeling defines specific restrictions and cautions:

  • Contraindications: Use is strictly contraindicated in individuals with severe renal insufficiency (severe kidney disease), pre-existing hypercalcemia, or known hypersensitivity to the active ingredients. A history of nephrolithiasis (kidney stones) is also a restricting factor.
  • Population Cautions: Patients with mild to moderate renal impairment and older adults require particular caution due to increased risk of mineral accumulation. The risk of toxicity is explicitly associated with long-term, high-dose exposure.

Overdose and Emergency Response

Overdose involving Mag64 (Magnesium Chloride and Calcium Carbonate) is primarily associated with Hypermagnesemia, which can lead to severe systemic effects as documented in government regulatory information.

Documented Manifestations and Progression

Official overdose manifestations include cardiovascular changes such as hypotension (low blood pressure) and bradycardia (slow heart rate). Neurologically, signs progress from confusion and drowsiness to the loss of deep tendon reflexes (areflexia), which is a critical clinical sign indicating severe toxicity. Gastrointestinal symptoms, including nausea and vomiting, are also documented.

When to Seek Immediate Medical Help

The onset of severe or life-threatening symptoms requires immediate medical attention. Regulatory documents explicitly state that the sharp drop in blood pressure, signs of circulatory collapse, and respiratory depression are triggers for urgent care. The disappearance of the patellar reflex is a key clinical sign noted in official documentation that necessitates immediate medical intervention to prevent progression to respiratory or cardiac arrest. Patients with renal impairment are documented to have an increased risk of severe toxicity due to impaired mineral excretion.

Official Emergency Management

The peripheral effects of severe toxicity are officially described as being antagonized by the intravenous administration of a calcium salt (e.g., Calcium Gluconate). Supportive measures documented in official labeling include providing artificial ventilation if respiratory paralysis occurs, along with using intravenous fluids and diuretics to enhance mineral excretion. Monitoring must include testing the patellar reflex, monitoring serum magnesium levels, and obtaining an ECG.

Therapeutic Uses of Mag64

Mag64 is commonly used across therapeutic domains where additional supportive management is needed in contexts involving systemic mineral imbalance. This mineral combination is considered relevant in situations where patients experience symptoms that become more disruptive during flare-ups linked to a chronic lack of essential electrolytes. It is commonly used to help with symptoms of increased neurological or muscular activity, such as involuntary muscle cramps, spasms, and tension.

This supportive approach is considered relevant for use in conditions where symptoms may intensify temporarily, including Hypomagnesemia, concerns regarding long-term bone structure maintenance, and systemic depletion following periods of high physiological stress. Mag64 supports patients during difficult episodes by easing distress and may help patients cope more steadily with symptom fluctuations.

“This supplement provides support that helps ease the overall symptom burden and assists with maintaining functional stability.”


Quick Fact: Support for Symptoms of Muscle Cramps and Tension Mag64 is commonly used to help ease symptoms of increased neurological or muscular activity that interfere with daily functioning, assisting with managing discomfort and contributing to easing the overall symptom load during symptomatic periods.

Regulatory References

  1. NIH MedlinePlus overview of Magnesium

Eligibility and Restrictions for Use

Eligibility to Use Mag64: Official Regulatory Guidelines

Eligibility for Mag64, a combination mineral supplement (Magnesium Chloride and Calcium Carbonate), is strictly defined by regulatory authorities to prevent mineral accumulation and toxicity.

Populations Who Must Not Use Mag64 (Contraindications)

Official labeling contraindicates the use of Mag64 in patients with several serious conditions:

  • Severe Renal Impairment: Patients with significant kidney failure must not use this product due to the high risk of hypermagnesemia (excessive blood magnesium levels), which the kidneys cannot excrete.
  • Pre-existing Electrolyte Imbalance: Individuals with documented hypermagnesemia or hypercalcemia (excessive blood calcium levels) are contraindicated, as the supplement would exacerbate these conditions.
  • Hypersensitivity: Use is prohibited in patients with a known allergy to Magnesium Chloride, Calcium Carbonate, or any components of the tablet.

Age and Conditional Restrictions

  • Adults (≥ 18 years): This is the standard eligible population for use in dietary supplementation.
  • Pediatric Use: Use in children under 12 years is generally not recommended because the safety and efficacy profile for this adult formulation are not established in this age group.
  • Pregnancy and Lactation: Use is generally considered acceptable when medically necessary and under a physician's supervision, provided mineral intake remains within recommended daily limits.
  • Restricted Use: Patients with moderate renal impairment or those taking certain medications (e.g., cardiac glycosides) should only use Mag64 with caution and under medical guidance.

What should I know about interactions with other medicines?

Mag64 Interactions with other medicines and products

Mag64 (a magnesium-containing product) can interact with a variety of medications, primarily by affecting their absorption or by having additive effects on mineral levels in the body. It is important to consult a healthcare professional regarding potential interactions before starting Mag64.


Reduced Absorption of Other Drugs

Magnesium can bind to certain medications in the digestive tract, which can significantly reduce the amount of the drug absorbed into the bloodstream, making it less effective. To prevent this, doses must be separated in time. Affected drugs include:

  • Certain Antibiotics: Specifically, tetracyclines (e.g., doxycycline) and fluoroquinolones (e.g., ciprofloxacin).
  • Bisphosphonates: Drugs used to treat osteoporosis (e.g., alendronate).
  • Levothyroxine: Used to treat an underactive thyroid.

Alteration of Blood Mineral Levels

Some medications can alter the body's magnesium levels, either by causing excessive loss or by increasing retention, which may be amplified by taking a magnesium supplement. Conversely, Mag64 may potentiate the effects of some drugs.

  • Diuretics (Water Pills): Certain types, such as loop and thiazide diuretics, can increase magnesium loss. Other types, like potassium-sparing diuretics, may increase the risk of elevated magnesium levels.
  • Proton Pump Inhibitors (PPIs): Long-term use of these acid-reducing medications (e.g., omeprazole, esomeprazole) has been associated with low magnesium levels.
  • Blood Pressure Medications: Mag64 may have additive blood-pressure-lowering effects when taken with certain calcium channel blockers.

Consult your doctor or pharmacist for advice on appropriate timing of doses or whether a medication adjustment is necessary.

Mechanism of Action

The mechanistic effects of Mag64 are governed by the established physiological roles of the magnesium ion Mg^2+, which is released upon intestinal absorption and contributes to systemic concentration.

Enzyme Co-factor and Cellular Energy Regulation

Magnesium acts as a co-factor for over 300 enzymatic reactions, including those involving ATP (adenosine triphosphate) such as oxidative phosphorylation and glycolysis. This interaction is central to metabolic processes, modifying early molecular steps to regulate energy-producing cascades and supporting downstream cellular processes.

Neuromuscular and Cardiac Pathway Modulation

Mg^2+ affects systems where ion transmitters dominate, serving as a physiological calcium channel blocker and a necessary co-factor for the Na^+/ K^+-ATPase pump. This engages mechanisms that regulate neuronal and muscular excitation, modulating signaling at the neuromuscular junction and affecting electrical conductance in cardiac tissue.

Bone Signaling and Homeostasis Support

The ion is necessary for protein synthesis and the normal function of parathyroid hormone, which influences calcium homeostasis. These modifications support a regulated state within pathways controlling bone matrix development and Mg^2+-dependent skeletal tissue regulation.

Dosage and Administration Information

How to Use Mag64: Official Administration Guidelines

Mag64 is an Over-the-Counter (OTC) Oral Delayed-Release Tablet containing Magnesium Chloride and Calcium Carbonate. Instructions for its use focus on the procedure for administration and standard dosing schedules.


Official Administration and Dosing

Mag64 is only approved for Oral administration. The dosage is designed to supplement dietary intake and maintain mineral levels, following standard guidelines for mineral replenishment.

Instruction Category Official Guideline
Route of Administration Oral only.
Standard Daily Dose Typically 1 to 2 tablets per dose, taken once or twice daily, for a total of 2 to 4 tablets per 24 hours.
Timing with Meals Often advised to be taken with a meal to aid absorption and reduce the potential for digestive upset.

Required Administration Procedure

Due to the medicine’s form as a Delayed-Release Tablet, specific steps must be followed to ensure the active ingredients are properly released in the small intestine:

  1. The tablet must be swallowed whole.
  2. It is strictly forbidden to crush, chew, or break the tablet, as this compromises the enteric coating.

Co-Administration Timing and Special Populations

Patients are instructed to separate the administration of Mag64 from many other oral medicines. This is necessary because elemental calcium and magnesium can interfere with the absorption of certain other drug classes. A separation of at least 2 hours before or 2 hours after taking other oral medications is required.

Dosing requirements for specific groups, such as children and during pregnancy or lactation, must be based on the specific Recommended Dietary Allowances (RDAs) and should follow the advice of a healthcare provider.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Mag64


1. Evidence for the Correction of Mineral Imbalance (Hypomagnesemia)

Research has examined the use of oral mineral salts within Randomized Controlled Trials (RCTs) and established clinical protocols. These studies primarily monitored biomarker outcomes—specifically, how serum and urinary magnesium levels changed after administration—to document the correction of a diagnosed deficiency. Studies reported measurements showing that oral administration was associated with the reversal of acute mineral imbalance detected through laboratory testing. The research observed that mineral supplementation contributed to achieving normal electrolyte values. While the correction of low levels is established, long-term functional outcomes are not consistently characterized for this specific mineral combination.


2. Research on Muscular Symptoms and Neuromuscular Activity

Research was studied for outcomes related to physical discomfort, such as muscle cramps and spasms, through placebo-controlled RCTs and systematic reviews. Research reports indicate varied and inconsistent findings regarding the effect on general muscle cramps. Some smaller trials reported how symptoms evolved in the observed populations, while other, larger studies did not observe similar patterns. The evidence quality varies across studies, and the research is often limited and heterogeneous. There is limited information on how the combined use of magnesium and calcium (as found in Mag64) compares to taking the minerals separately.


6. Areas of Uncertainty and Research Gaps

Scientific reviews and analysis examined the existing evidence base to identify where the current research provides limited or inconsistent insight. Evidence quality varies across studies, and the research highlights what is known—and what is still uncertain. Specifically, comparative evidence is lacking between Mag64’s specific two-mineral combination and single-mineral alternatives. Key limitations include that long-term outcomes are not fully established, and findings were mixed regarding the overall consistency of effect on neuromuscular symptoms.

Key Studies & References

  1. Impact of magnesium on bone health in older adults: A systematic review and meta-analysis
  2. Hypomagnesemia (Merck Manual Professional Edition)

Frequently Asked Questions (FAQ)

Common questions about Mag64 (FAQ)

Q: Is it true that Mag64 can cause changes in sleep patterns?

Official safety information lists drowsiness and confusion as potential signs of severe mineral imbalance. Other sleep changes, such as insomnia or general sleep disturbances, are not explicitly noted in the regulatory documents. Concerns about unexpected changes can be discussed with a healthcare provider.

Q: What happens if I miss taking Mag64 one day?

General patient instructions recommend continuing with the regular schedule if a dose is missed. Product information generally states that compensating for a missed dose by taking extra is not recommended. Consistent and regular use is defined by the dosing schedule provided on the product label.

Q: Can Mag64 affect the results of standard lab tests?

Yes, official regulatory information indicates that Mag64 is formulated to replenish the body's mineral levels. Because of this, it can directly affect the laboratory test results for serum magnesium and serum calcium. These electrolyte levels are commonly monitored by healthcare providers during mineral supplementation.

Q: What is the risk of becoming dependent on Mag64?

Mag64 is an Over-the-Counter (OTC) mineral supplement and is not classified as a controlled substance by government agencies. Official information does not indicate a risk of dependence or addiction associated with its use.

Q: Can people with liver problems use Mag64 safely?

The primary caution and need for dosage adjustment with Mag64 relate to impaired kidney function, as the kidneys are responsible for excreting excess minerals. Official documents do not typically specify dosage adjustments for patients solely with liver impairment. Reviewing one's full medical history with a healthcare professional before use is standard procedure.

Q: What are the most common reasons someone might stop taking Mag64?

According to post-marketing surveillance and safety reports, the most common reasons patients stop using mineral supplements are related to Gastrointestinal (GI) side effects. These reactions frequently include diarrhea, constipation, or general stomach upset.

Q: Does Mag64 cause weight gain or weight loss?

Weight gain or weight loss are not listed as common or serious adverse reactions in the official product labeling and safety information. Side effects are primarily confined to the digestive and nervous systems in cases of imbalance.

Q: Is it a problem if I occasionally drink alcohol while using Mag64?

Official product labeling generally does not list a specific interaction between the active mineral ingredients in Mag64 and moderate alcohol consumption. However, if Mag64 causes drowsiness or dizziness, caution should be exercised when drinking alcohol.

Q: Is there a generic version of Mag64 available?

Yes, official product listings indicate that the specific combination of magnesium chloride and calcium carbonate in a delayed-release oral tablet is available. This allows the product to be sold as both a brand-name supplement and under its full generic name.

Q: What does it mean if Mag64 is classified as a 'Schedule X' drug?

Mag64 is classified by regulatory bodies as an Over-the-Counter (OTC) Mineral Supplement. This product is not listed or scheduled as a controlled substance with potential for abuse by any government agency.

Q: What specific ingredients in Mag64 cause it to have certain side effects?

Gastrointestinal side effects, such as diarrhea or stomach upset, are often associated with the presence of high concentrations of magnesium or calcium salts. These effects are generally more common at higher intake levels.

Q: Can Mag64 be taken with common pain relievers like ibuprofen or acetaminophen?

While specific pain relievers like ibuprofen or acetaminophen are not individually highlighted in interaction warnings, Mag64 can affect the absorption of many oral medications. To prevent this interference, the product labeling requires separating Mag64 from all other oral medicines by at least two hours.

Q: What are the warning signs that Mag64 might not be working for someone?

Mag64 is intended to correct mineral imbalances. Official information suggests that signs of non-response would include the persistence or worsening of the symptoms (e.g., muscle symptoms or signs of deficiency) that led to its use, despite consistent and correct dosing.

Q: What patient population was Mag64 originally tested on in clinical trials?

Clinical trials that established the efficacy of Mag64 often focused on adult populations with documented mineral deficiencies or those identified with relevant risk factors. The full details regarding the demographics (such as age range and gender distribution) of these trials are available in regulatory documents.

Q: What should I do if the side effects of Mag64 are bothering me?

Official patient information advises that discontinuation of use may be appropriate if unwanted side effects are experienced. For any severe or concerning side effects, seeking immediate emergency medical help is recommended.

Q: What happens if I stop taking Mag64 suddenly?

Official guidelines on mineral supplements suggest that stopping use suddenly generally does not cause defined withdrawal symptoms. However, if Mag64 was being used to address a deficiency, the original mineral imbalance may gradually return if the underlying cause is not resolved.

Q: Are there any specific lifestyle changes recommended while taking Mag64?

Since Mag64 is a supplement intended to support dietary intake, a healthy, balanced diet is implicitly recommended to complement its use. Regulatory guidance focuses primarily on administration procedures and drug interactions.

Q: What does 'contraindicated' mean in relation to Mag64?

The term contraindication refers to a condition or circumstance, such as severe kidney disease or pre-existing high mineral levels, that makes using Mag64 strictly inadvisable. Using the product when contraindicated could cause harm or severe adverse effects.

Q: Is Mag64 commonly prescribed for a specific duration?

Official Over-the-Counter (OTC) guidelines generally advise not taking supplements for longer than two weeks unless a healthcare professional has recommended extended use. Use beyond the general guidance is typically overseen by a healthcare professional.

Q: Can Mag64 interact with birth control pills?

Mag64 has the potential to interfere with the absorption of many oral medications, including some oral contraceptives, due to its mineral content. Patients are typically instructed to separate Mag64 from all oral medicines by two hours to minimize this risk.

Q: Does Mag64 contain gluten or common allergens?

Official product labeling includes a list of all inactive ingredients (excipients) used in the delayed-release tablet. The inactive ingredients list can be used to confirm the presence or absence of specific allergens like gluten.

Q: What factors might make Mag64 less effective for some people?

Effectiveness can be reduced if Mag64 is taken with certain interacting medications (e.g., antibiotics or thyroid drugs) that interfere with its absorption. Underlying issues, such as severe digestive disorders, may also reduce the body's ability to utilize the mineral content.

Q: What should I do if I suspect an overdose of Mag64?

In the event of a suspected overdose, official regulatory warnings advise seeking immediate emergency medical attention. Contacting a local Poison Control Center right away is also an option.

Q: Are there any common foods or drinks that interact with Mag64?

Official documents advise that the absorption of minerals can be reduced by certain foods. Foods high in oxalic acid (like spinach) or phytic acid (like whole grains) may interfere with calcium absorption. Separation of the dose from these specific foods is a point of discussion with a healthcare provider.

Q: Do older adults typically have different side effects when taking Mag64?

Older adults are specifically cautioned to use the supplement with care because they have an increased risk of mineral accumulation, particularly hypermagnesemia, due to age-related changes in kidney function. This may increase the likelihood of systemic side effects like confusion or slow heart rate.

Q: If I am taking a supplement, do I need to worry about interactions with Mag64?

Yes, interactions can occur if other supplements contain high levels of calcium, magnesium, or other minerals (like iron) that interfere with absorption or create an additive effect. All over-the-counter supplements should be reviewed by a healthcare provider before concurrent use.

Q: How does Mag64 impact the ability to drive or operate machinery?

Because serious adverse reactions related to mineral imbalance can include drowsiness and confusion, patients are advised to be aware of how the supplement affects them. Understanding one's personal response to the product is key before engaging in activities like driving or operating complex machinery.

Q: Does taking Mag64 affect my blood pressure?

Regulatory information notes that Mag64 may have additive blood-pressure-lowering effects if taken at the same time as certain existing blood pressure medications. Magnesium and calcium are known to modulate blood pressure, and this potential interaction is a key consideration.

Q: How does Mag64 affect individuals who have a history of heart issues?

The minerals in Mag64 affect cardiac conduction and heart rhythm. The product should be used with caution in patients with pre-existing heart conditions due to the risk that a severe mineral imbalance could lead to serious symptoms like Bradycardia (a slow heart rate).

Q: Is Mag64 known to interact with herbal remedies?

Official product labeling advises patients to notify their healthcare provider of all medications, vitamins, and herbal products they are using. This is because potential interactions with specific herbal remedies have not been universally tested or definitively ruled out in regulatory studies.

How should Mag64 be stored and disposed of?

Storage and Disposal Requirements for Mag64

The storage and handling of Mag64 (Magnesium Chloride/Calcium Carbonate Delayed-Release Tablet) must strictly follow official regulatory guidelines to maintain product integrity and ensure safety.

Storage Conditions

Requirement Official Regulatory Mandate
Temperature Store at room temperature, at or below 25°C (77°F), away from excess heat.
Container Keep the medication in the original container with the cap tightly closed and protect it from moisture and humidity.
Protection Keep out of the sight and reach of children and use locked safety caps on the container.

Disposal

Unused or expired Mag64 should be disposed of by utilizing a drug take-back program. If this option is unavailable, the product may be disposed of in the household trash by mixing the tablets with an unappealing substance (e.g., used coffee grounds or dirt) and sealing the mixture in a container before discarding. Do not dispose of the medicine in drains or sewerage systems.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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