Hima

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Hima

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Hima

Quick Facts

Property Description
Active Ingredients Zinc Oxide, Zinc Sulfate
Form Semisolid (Cream, Ointment, Paste)
Pharmacological Class Topical Protectant, Astringent
Common Use Protection and relief of minor skin irritations
Origin Synthetic inorganic compounds

Hima: Definition and Pharmacological Classification

Hima is defined as a proprietary dermatological pharmaceutical preparation categorized primarily as a Topical Protectant and Astringent agent, designed exclusively for dermal route application. This status means the medication offers localized surface action rather than systemic effects. Hima is formulated as a fixed-dose combination product, an approach that combines agents with distinct mechanisms for surface-level action.

Composition and Active Ingredients (Zinc Oxide, Zinc Sulfate)

The active ingredients in Hima are the inorganic salts Zinc Oxide (ZnO) and Zinc Sulfate (ZnSO4), which are derived from synthetic inorganic compounds. This formulation is prepared as a semisolid dosage form, such as an ointment, cream, or paste. The Zinc Oxide component is recognized as a skin protectant, contributing to the product's role in establishing a physical barrier against external irritants.

The semisolid form and the combination of ingredients differentiate Hima by offering a durable and targeted protective layer, making it suitable for sustained coverage on friction points or localized areas. The product’s classification aligns it with over-the-counter (OTC) medication classes used for non-prescription skin support.

General Purpose: What Does Hima Help Relieve?

Hima's general purpose is to relieve minor dermal discomfort and protect the skin. Topical zinc compounds are utilized for their soothing and tissue-protective properties. The combination establishes a physical skin protection barrier while utilizing the mild astringency of Zinc Sulfate to promote a drier environment, providing defense and support for irritated skin areas.

Regulatory References

  1. dermatological pharmaceutical preparation - NCI
  2. Routes of Drug Administration - NCI
  3. Inorganic Salts - PubChem
  4. Zinc Oxide Drug Information - MedlinePlus
  5. Zinc Sulfate Drug Information - MedlinePlus
  6. Synthetic Compound - NCI
  7. Dosage Form - NCI
  8. soothing and tissue-protective properties

What side effects are possible with Hima?

Possible Side Effects and Safety Information

The official safety profile for Hima, a preparation containing Zinc Oxide and Zinc Sulfate, is predominantly characterized by adverse reactions localized to the application site, consistent with its classification as a topical protectant for external use. This safety information is derived from authoritative government regulatory documents, which typically focus on local effects due to the negligible systemic absorption of the active ingredients.


Documented Adverse Reactions and Frequencies

Adverse reactions associated with topical zinc compounds are mainly categorized under Skin and subcutaneous tissue disorders. The most frequently noted local effects include:

  • Itching (pruritus)
  • Skin rash or hives (urticaria)
  • Localized burning or stinging at the application site

For many of these localized reactions, regulatory documentation often reports the frequency not known, as the incidence is derived primarily from spontaneous reporting rather than controlled clinical trials.


High-Level Safety Considerations

The most serious safety concern documented in regulatory texts is the potential for Hypersensitivity Reactions, which falls under Immune system disorders. Signs of a severe allergic reaction, such as swelling of the face, throat, or tongue, or difficulty breathing, represent a rare but clinically significant adverse reaction tier.

Due to the nature of the product, specific safety warnings related to renal or hepatic impairment are typically absent, as systemic exposure is minimal. However, official labeling mandates fundamental limitations:

  • The product is strictly for External Use Only.
  • It is contraindicated in individuals with known hypersensitivity or allergy to the active ingredients.
  • Contact with the eyes must be avoided.

Regulatory safety notes also indicate that use must be discontinued if the treated condition worsens or does not show improvement within a specified period.

Overdose and Emergency Response

Overdose and When to Seek Help

Overdose with Hima is a medical emergency that can be fatal and requires immediate action. Symptoms are primarily related to severe Central Nervous System (CNS) and respiratory depression.

Documented Overdose Manifestations

Symptoms of an overdose may include profound drowsiness, disorientation, or unconsciousness (coma), and extremely small (pinpoint) pupils. The most critical manifestation is slow and shallow breathing that can progress to complete cessation of breathing (apnea).

When to Seek Immediate Medical Help

If you suspect an overdose, seek immediate medical attention by calling the local emergency number (such as 911 in the U.S.) or the Poison Control Center (1-800-222-1222). Do not attempt to let the person 'sleep it off' or treat with home remedies.

Required Emergency Actions

The immediate treatment for Hima overdose is maintaining an open airway and providing rescue breathing. The opioid effects of Hima can be rapidly reversed by the administration of naloxone, which is an antidote that can restore normal breathing. Due to the high risk, individuals using the drug are encouraged to carry naloxone. Using Hima with alcohol or other drugs significantly increases the risk of a stronger, more unpredictable, and potentially fatal overdose.

Therapeutic Uses of Hima

What Hima Treats: Main Uses and Benefits

Hima is primarily used to provide supportive therapeutic relief in situations involving certain distressing dermatological symptoms. It is applied when symptoms create noticeable interference with daily stability and comfort.

Hima is utilized to help manage the discomfort associated with minor skin irritations and symptoms across conditions such as diaper rash, chafed skin, windburn, chapped skin, minor cuts, scrapes, and first-degree burns. This symptomatic support is also relevant for managing manifestations like oozing and weeping related to irritants such as poison ivy.

The medication supports the handling of distressing symptoms related to wetness exposure and friction, contributing to improved comfort during symptomatic periods. The primary benefit provides support that helps ease the overall symptom load. This application offers symptomatic relief that may help patients cope more steadily with symptom fluctuations in both acute and chronic irritation contexts.


Quick Fact: Relief for Surface Discomfort

Symptom Focus Conditions Addressed Primary Benefit
Redness & Soreness Diaper rash, chafing, minor burns Supports the patient during difficult episodes by easing distress
Oozing & Weeping Poison ivy, acute irritations Supports general well-being during symptomatic phases
Surface Disruption Chapped skin, windburn, minor cuts Contributes to improved comfort during periods of heightened symptoms

Regulatory References

  1. DailyMed Label for Zinc Oxide Ointment

Eligibility and Restrictions for Use

Who Can and Cannot Use Hima?

Eligibility for Hima (carboprost tromethamine) is strictly defined by official regulatory bodies, focusing on the patient's existing health status and the context of use.

Do NOT Use This Medicine (Contraindications):

This medicine is absolutely contraindicated and must not be used by patients with:

  • Hypersensitivity or allergy to Hima or any of its components.
  • Acute pelvic inflammatory disease (PID).
  • Active cardiac, pulmonary, renal, or hepatic (liver) disease.

Use Requires Special Caution (Precautions):

Healthcare professionals must use this medicine with caution in patients who have a history of certain conditions, including:

  • Asthma or other lung diseases.
  • High or low blood pressure (hypertension/hypotension) or cardiovascular disease.
  • Renal or hepatic disease (even if not currently active).
  • Diabetes, epilepsy, anemia, or jaundice.
  • A compromised (scarred) uterus.

Other Eligibility Contexts:

  • Pregnancy: It is contraindicated for use during pregnancy, except for the therapeutic indications of managing refractory postpartum hemorrhage or in certain procedures for terminating non-viable pregnancies (13th to 20th weeks of gestation).
  • Setting: This medicine must be administered only by medically trained personnel in a hospital setting equipped with immediate intensive care and acute surgical facilities.

What should I know about interactions with other medicines?

Interactions with other medicines and products — official regulatory information for Hima

The interaction profile of Hima, a dermal product containing Zinc Oxide and Zinc Sulfate, is structured by its non-systemic route of application. Regulatory authorities document that the product has negligible systemic absorption, which fundamentally limits the potential for systemic drug interactions.

Interaction scope Officially Documented Information
Medicinal product categories with documented interactions: Other topical preparations (local physical interference).
Specific interacting medicines (if explicitly listed): None listed; interaction relates to the physical effect of co-applied products.
Mechanistic basis of interactions (only if stated in label): Local physical interference (disruption of the protective barrier). No systemic pharmacokinetic or pharmacodynamic mechanisms are documented.
Timing-based interaction rules (if applicable): No mandatory timing separation from systemic drugs is documented.
Population-specific interaction notes (if applicable): None documented.
Interaction-related restrictions: Co-application of other topical preparations on the same area may interfere with the protective barrier function.
Interaction classifications (high-level) Officially Documented Information
Interaction severity classification (as defined in official documents): No formal severity classification is assigned due to the non-systemic nature of the product.
Regulatory basis (EMA / FDA / etc.): Defined by general monographs and labeling for non-systemic topical protectants.
Interaction-context constraints (as defined in official documents): Interactions are limited to the site of application (local dermal interaction) and are not systemic.

Resulting interaction structure

Official interaction statements:

  • Negligible Systemic Interaction: Regulatory labeling indicates that pharmacokinetic interactions (e.g., those involving CYP enzymes or drug transporters) with orally or parenterally administered medicinal products are not formally documented.
  • Absence of Contraindications: No combinations are classified as formally contraindicated by regulatory authorities based on a systemic interaction risk with Hima.
  • Local Interference: The only documented constraint is the local physical interference caused by the co-application of other topical preparations, which may compromise the protective barrier.

Connection to the overall interaction profile:

The regulatory documentation defines the product’s interaction profile by its status as a non-systemic topical protectant. This classification explicitly excludes the presence of systemic interaction risks, resulting in an absence of documented metabolic or transporter-based interactions. The only officially noted constraint is the procedural requirement of managing other topicals to preserve physical barrier integrity.

Mechanism of Action

How Hima Works

The action of this combination product is entirely local and operates through two complementary mechanisms to establish a physical layer and alter local surface conditions.


️ Establishing the Physical Barrier and Shielding Mechanism

The primary action of Zinc Oxide is to engage the Physical Barrier Pathway by forming a continuous, inert layer over the epidermal surface. This is a physical protection/shielding mechanism where the formed layer prevents direct contact between the skin and external physical or chemical irritants. This action modifies the initial steps of the damage cascade by eliminating the trigger, which in turn reduces the probability of downstream signaling associated with local inflammation.


Astringent Action and Tissue Hydration Modulation

The second mechanism involves Zinc Sulfate which initiates rapid astringency. This is a chemical interaction that targets superficial skin proteins, causing their coagulation and precipitation. This coagulation tightens the tissue and lowers the permeability of the local cell membranes. The resulting physiological effect is the active modulation of the Tissue Hydration Pathway, which lowers membrane permeability and promotes a state of reduced local moisture.


Zn^2+ Ion-Mediated Biochemical Support

Both active ingredients provide the Zinc ion ( Zn^2+), which acts as a modulator and cofactor in several dermal repair and anti-inflammatory pathways. This supporting mechanism reinforces the primary physical and astringent actions by assisting the regulation of local enzymatic activity and signaling, which impacts the structural dynamics of the epidermal layer.

Dosage and Administration Information

How Hima is Used: Administration Guidelines

The administration of Hima, a topical protectant containing Zinc Oxide and Zinc Sulfate, is described by instructions detailing its procedural application, frequency, and preparation requirements.


Administration Scope

Feature Guideline
Route of administration Application is strictly topical to the dermal surface, meaning the product is for external use only.
Dosing schedule The application amount is non-quantifiable, but a sufficient quantity is applied liberally to ensure the entire affected area is completely covered.
Frequency and Schedule The product is used on an as-needed or context-driven basis. For conditions like diaper rash, reapplication is typically performed with each diaper change, especially when exposure to wetness may be prolonged.
Preparation requirements The skin area is cleansed with mild soap and water and allowed to dry completely before the semisolid preparation is applied.
Age-group administration rules The same application principles and frequency apply to both pediatric (infants) and adult populations for the indicated uses.

Resulting Procedural Structure

The use protocol follows a sequence to ensure proper barrier formation. The procedural structure is defined by three key steps:

  • Preparation: Cleanse the intended application area and allow the skin to dry completely.
  • Application: Apply the semisolid preparation liberally to form a continuous, covering layer.
  • Repetition: Reapply as necessary, particularly when the protective layer is removed due to friction or wetness exposure.

This structured approach describes the conditions under which the product is used (clean, dry skin) and defines a usage pattern that is continuous and responsive to environmental factors rather than a fixed time schedule.

Recent Clinical Evidence

Research evidence / Overview of studies for Hima


Evidence for Use in Diaper Dermatitis (Diaper Rash)

Research has examined the use of topical preparations containing zinc compounds, like Hima, in conditions involving periods of heightened symptoms, specifically diaper dermatitis. The evidence base includes short-term Randomized Controlled Trials (RCTs) and Systematic Reviews that explore outcomes in infants and young children. These studies monitored outcomes related to physical discomfort and symptom intensity, such as the rate of change in skin condition metrics and the change in rash severity scores over defined time intervals.

The studies report how symptoms evolved in the observed populations over treatment durations typically lasting less than one week. Findings describe patterns observed in the studies related to the function as a physical barrier and astringent action associated with these topical ingredients. This research contributes to the broader evidence landscape supporting the role of zinc compounds as a barrier protectant evaluated in research contexts involving fluctuating or unstable symptoms of the diaper area.


Evidence for Use in Minor Skin Irritations and Protection

Research explored outcomes in settings involving minor skin conditions, including small cuts, scrapes, chafed skin, and discomfort from irritant exposure. This evidence is supported by regulatory consensus regarding the compound's role as an over-the-counter (OTC) Topical Protectant, as well as data from controlled human skin irritation models. The research examined outcomes related to inflammatory or irritative states, such as the reduction in redness (erythema), temporary relief from perceived discomfort, and the ability to dry out oozing or weeping skin surfaces.

These studies focused on episodes where symptoms become more noticeable and often used healthy adult volunteers to monitor the skin's response to irritants. Research describes the ability of these preparations to create a physical barrier and leverage the mild astringency of zinc sulfate to manage wetness, which was observed in some studies to provide temporary support during acute irritative episodes.


What is Still Uncertain About Hima's Research Base

The research landscape has limitations. For instance, long-term effects are not fully established, meaning the current research cannot provide comprehensive insight into sustained or preventative use over many months. Study designs primarily reflect acute intervention, and follow-up durations were limited, typically lasting only a few days to one week. Furthermore, data for certain groups remain insufficient, particularly evidence tracking outcomes in populations with pre-existing chronic skin conditions.

Key Studies & References

  1. Zinc compounds: MedlinePlus Drug Information
  2. DailyMed Label for Zinc Oxide Ointment

Frequently Asked Questions (FAQ)

Common questions about Hima (FAQ)

Q: How quickly does Hima typically start to have an effect?

A: Topical preparations containing zinc compounds are often described as beginning to work shortly after application by creating a physical barrier. Official regulatory labeling advises assessing initial response within 7 days, as use should be stopped if symptoms worsen or do not show improvement after this timeframe.

Q: Is Hima used for long-term health issues or just short-term treatment?

A: Hima is intended for short-term, acute skin protection and relief of minor irritations. Official product information advises stopping use if the condition lasts more than 7 days, or if it clears up and occurs again quickly. This guidance indicates that the approved scope of the product is for temporary, acute skin issues.

Q: Can taking Hima cause feelings of fatigue or tiredness?

A: According to official regulatory documents for this topical protectant, systemic effects such as fatigue or tiredness are not listed as documented adverse reactions. Because the product is only applied externally and has minimal absorption into the bloodstream, side effects are usually limited to the application site.

Q: Can consuming alcohol while taking Hima cause problems?

A: Given its topical application, the product has negligible systemic absorption, and regulatory documents do not list warnings or interactions related to alcohol. This lack of interaction is consistent with the product’s non-systemic use.

Q: What should I do if I forget to take a scheduled amount of Hima?

A: Hima is not a fixed-schedule medication but is used on an 'as-needed' basis, such as applying it when the area needs protection. Official instructions do not include a specific procedure for a 'missed dose' because the application should simply be resumed when the protective layer is required.

Q: What happens if I stop taking Hima suddenly?

A: Official regulatory documents do not describe any known risks of withdrawal symptoms or rebound effects when use of this topical preparation is suddenly discontinued. If the condition is improving, use can typically be stopped when the protective layer is no longer necessary.

Q: Is Hima safe for use during pregnancy or while breastfeeding?

A: Regulatory guidance indicates that the manufacturer makes no specific recommendation regarding use during pregnancy or while breastfeeding. Given the minimal systemic absorption of the active ingredients, the risk is considered low. Use of the product during these periods should be reviewed based on individual context.

Q: Are there any long-term health risks associated with taking Hima for many years?

A: The available regulatory documents and research evidence primarily reflect the results of short-term studies for acute conditions. As a result, the long-term effects of using this topical preparation continuously over many months or years are not fully established in the current evidence base.

Q: What is the typical length of treatment with Hima?

A: Hima is intended for acute, short-term use for temporary skin irritations. Official labeling instructs users to stop use if the condition does not improve within 7 days, which defines the timeframe for use without professional consultation.

Q: What is the purpose of the different strengths of Hima tablets?

A: Hima is not available as a tablet but as a semisolid formulation (ointment, cream, or paste) for topical use. Various strengths are available across different topical products to address varying needs, as determined by professional context.

Q: Is Hima primarily processed by the liver?

A: No. When applied to the skin, Hima has negligible systemic absorption, meaning very little of the active ingredients enters the bloodstream. Hima is not processed by these organs in the same way that oral medicines are, due to its minimal systemic absorption.

Q: Can Hima be used by children?

A: Yes, official labeling confirms that Hima is indicated for use by children, including infants, for its specific approved conditions such as diaper rash. The same non-directive application principles apply to both pediatric and adult populations.

Q: Is Hima generally considered safe for older adults?

A: Regulatory documents do not include specific safety warnings for older adults. This is consistent with the product’s negligible systemic absorption, which limits the risks to localized effects on the skin that are not specific to any age group.

Q: Are there any common over-the-counter medicines that interact with Hima?

A: Official documentation states that Hima does not have known systemic interactions with other medicines taken by mouth, including other over-the-counter products. The only documented constraint is the local physical interference when other topical preparations are co-applied on the same area.

Q: Can Hima affect the results of standard lab tests?

A: Due to the product's classification as a non-systemic topical protectant and its negligible systemic absorption, it is not expected to interfere with the results of standard blood or urine laboratory tests.

Q: Is Hima a type of pain reliever?

A: Hima is classified as a Topical Protectant and Astringent. While its purpose is to relieve minor discomfort by creating a protective barrier and soothing irritated skin, it is not classified or documented as a systemic pain reliever.

Q: Do I need to take Hima at a specific time of day?

A: No, Hima is used on an as-needed basis rather than according to a fixed time schedule. The instructions specify that it should be applied when needed, such as when the skin requires protection or when the prior layer has been removed.

Q: Is Hima known to cause weight gain or weight loss?

A: Systemic effects, such as changes in weight, are not listed in the official regulatory documents for this topical protectant. The adverse reactions reported are localized to the area of application.

Q: Are there any restrictions on driving or operating machinery while taking Hima?

A: No restrictions on driving or operating machinery are documented in the official labeling. The product is not associated with central nervous system side effects like drowsiness or dizziness because of its non-systemic nature.

Q: Does Hima contain any ingredients that cause allergic reactions?

A: Official labeling warns that Hima should not be used by individuals with a known hypersensitivity or allergy to its active ingredients (Zinc Oxide, Zinc Sulfate) or any of its inactive components. The full list of ingredients is provided in the product information for patients with known sensitivities.

Q: Are there any food types that need to be avoided while using Hima?

A: Regulatory documents do not list any specific dietary restrictions or food types that need to be avoided when using this topical preparation.

Q: Does Hima carry a risk of dependence or withdrawal symptoms?

A: Hima is classified as an Over-The-Counter topical product and is not considered a controlled substance. As such, regulatory documents do not indicate any risk of physical dependence or addiction.

Q: Can Hima interfere with birth control pills?

A: Due to the product's negligible absorption into the bloodstream, Hima is not expected to interfere with the metabolism or effectiveness of systemic medications, including oral birth control pills.

Q: What does it mean if Hima has a 'Black Box Warning'?

A: Hima does not carry a Black Box Warning. This is the strictest warning required by the FDA for certain prescription drugs and is reserved for products with significant, potentially life-threatening risks that are not associated with this topical protectant.

Q: Does Hima have an effect on sleep patterns?

A: Systemic effects on sleep patterns, such as causing insomnia or excessive drowsiness, are not listed in the official regulatory documents for this topical protectant. Reported side effects are localized to the skin.

Q: Can Hima make me more sensitive to sunlight?

A: Photosensitivity or increased sensitivity to sunlight is not listed among the documented adverse reactions in the official regulatory documents for this product.

Q: Are there restrictions on consuming grapefruit or grapefruit juice with Hima?

A: Regulatory documents do not list any warnings or restrictions related to consuming grapefruit or grapefruit juice. This type of interaction is typically associated with oral drugs that are systemically absorbed, which Hima is not.

Q: Can I take Hima if I have a history of heart issues?

A: Regulatory documents do not list pre-existing heart issues as a contraindication or precaution for this topical product. This is consistent with its non-systemic nature, as it is not absorbed internally.

Q: Is Hima considered a controlled substance?

A: No, Hima is classified as an Over-The-Counter (OTC) topical protectant and is not included on the FDA’s list of controlled substances.

Q: Why is Hima prescribed for certain conditions but not others?

A: Hima is approved only for specific surface-level conditions like diaper rash and minor skin irritations. This is because its mechanism of action—creating a physical protective barrier and providing astringency to dry weeping tissue—is only relevant to these indications, as defined by official regulatory labeling.

Q: Can Hima cause skin reactions or rashes?

A: Yes, official regulatory labeling lists localized skin rash, hives (urticaria), itching, burning, and stinging as documented adverse reactions associated with the use of this topical preparation. These effects are typically confined to the application area.

How should Hima be stored and disposed of?

Hima, a semisolid topical product, must be stored within a Controlled Room Temperature range, typically between 15 C and 30 C (59 F and 86 F), as specified in the official labeling. The product must be protected from freezing and excessive heat to maintain stability.

Storage and Safety

Official regulatory documents mandate that Hima be kept in its original container with the cap tightly closed. It must be stored out of the sight and reach of children to prevent accidental exposure. The product is strictly for external use only.

Disposal

Expired or unused Hima must be disposed of via an official drug take-back program. If no program is available, the medicine is not on the flush list and should be mixed with an undesirable substance, sealed in a bag, and discarded in the household trash, in accordance with federal guidelines.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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