Flipal

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Flipal

Quick Facts

Property Description
Active ingredient Mefenamic Acid
Form Capsule (for oral use)
Pharmacological class Nonsteroidal Anti-inflammatory Drug (NSAID)
Common use Relief of pain, inflammation, and fever
Origin Synthetic organic compound

What Type of Medicine is Flipal and What is its Composition?

Flipal is defined as a prescription-only medication whose active component is Mefenamic Acid, belonging to the high-level pharmacological class of Nonsteroidal Anti-inflammatory Drugs (NSAIDs). Mefenamic Acid is a synthetic organic compound identified chemically as an anthranilic acid derivative, a specialized subgroup known as a fenamate. It is an oral NSAID, a classification which is clinically recognized for its established efficacy in managing symptomatic pain. Flipal is provided as a single active ingredient product, typically administered in a capsule form for the oral route, often targeting the adult patient group for conditions that cause acute discomfort.


How Does Flipal Function at a High Level?

Flipal's fundamental function involves modulating the body's physical response by interfering with specific chemical messengers related to inflammation. The drug acts as a Cyclooxygenase (COX) inhibitor, thereby disrupting the synthesis of compounds known as prostaglandins. Prostaglandins are key biological mediators that signal pain, induce swelling, and elevate body temperature. By interrupting this chemical signaling pathway, the medicine achieves its overarching general purpose: providing simultaneous symptomatic relief through its analgesic (pain-relieving), anti-inflammatory (swelling-reducing), and antipyretic (fever-reducing) properties.

Regulatory References

  1. NIH LiverTox
  2. NIH DailyMed
  3. NIH MedlinePlus

What side effects are possible with Flipal?

Possible Side Effects and Safety Information for Flipal

Official regulatory documents from government health authorities organize the safety information for Flipal based on adverse reaction occurrence and systemic effects.

Adverse Reaction Scope

Adverse reactions are formally categorized using standardized frequency terms (e.g., very common, common, uncommon), which quantify the documented likelihood of each side effect. These effects are also grouped by System Organ Class (SOC), providing a systemic overview of the drug's influence across different parts of the body, such as the nervous system, gastrointestinal tract, and other major systems.

Classification Description
Very Common Occurring in 10% or more of patients.
Common Occurring in 1% to less than 10% of patients.
Uncommon Occurring in 0.1% to less than 1% of patients.
Serious Adverse Reactions Events documented as potentially life-threatening or fatal, which are detailed in official prescribing information.

Safety Considerations and Limitations

Contraindications are explicitly documented, outlining conditions or patient states where the medicine must not be used due to an unacceptable safety risk.

Population-Specific Safety Information addresses differing risk profiles for certain groups, such as patients with pre-existing conditions like severe liver impairment or those in unique physiological states, including pregnancy and breastfeeding, as documented by regulatory bodies. Furthermore, official safety data may indicate how the frequency or severity of certain adverse reactions is linked to the dose administered or the duration of exposure.

This structured approach—through frequency bands, system groupings, and population-specific notes—establishes the official risk profile of Flipal, defining both the likelihood of general side effects and the specific conditions that restrict its use.

Overdose and Emergency Response

Overdose and when to seek help

Official regulatory documentation requires that the potential for Flipal overdose be addressed by specific, immediate actions due to the risk of serious complications. Overdose information is based on documented clinical manifestations and emergency protocols.

Documented Manifestations and Risks

Classification Overdose Presentations
Documented Manifestations Symptoms may include central nervous system depression (e.g., extreme somnolence or agitation), along with signs of cardiovascular instability (e.g., tachycardia, hypotension).
Serious Outcomes Life-threatening complications listed in regulatory profiles include respiratory depression, seizures, coma, and cardiogenic shock.
Special Considerations Overdose severity may be heightened in specific groups, such as patients with pre-existing hepatic impairment, due to changes in drug clearance.

Emergency Response and Management

Immediate medical help is required for any known or suspected Flipal overdose.

Official instructions mandate that emergency medical services or a certified Poison Control Center be contacted immediately. Management involves primarily supportive and symptomatic care, including maintaining a patent airway and continuous observation. Gastric decontamination, such as administering activated charcoal, may be warranted in some cases. The product label will specify whether a specific pharmacological antidote is available; in its absence, supportive management remains the definitive treatment approach. Continuous monitoring of vital signs and physiological functions is typically required during and following the acute event.

Therapeutic Uses of Flipal

What Flipal Treats: Main Uses and Benefits

Flipal is used for managing symptom clusters that may become intense, such as symptoms related to physical discomfort and inflammatory or irritative states. Its use is aligned with established therapeutic domains.


Acute Symptom Management and Relief

Flipal is commonly used across conditions presenting with acute episodes, and may be part of symptomatic management for physical discomfort. Its use is relevant for easing symptom clusters that may become intense, such as those associated with physical discomfort, including headaches, muscular aches, joint pain, and is also relevant for easing symptoms linked to organ-specific functional stress, such as post-procedural discomfort.

Menstrual Symptom Relief

This medication plays a role in managing symptoms that create noticeable physiological strain, such as primary dysmenorrhea (painful periods), and is considered relevant in contexts involving episodic or fluctuating manifestations, such as heavy menstrual bleeding. Applied during phases of increased distress or discomfort, it helps ease challenging symptoms that cluster during the menstrual cycle. This assistance provides supportive relief when symptoms interfere with routine activities, and helps improve day-to-day comfort during symptomatic periods.

Quick Fact: Relief for Acute Discomfort
Common Use Context Conditions involving episodic or fluctuating manifestations
Primary Symptom Focus Symptoms related to physical discomfort and inflammation
Benefit Framing Provides supportive relief when symptoms interfere with routine activities

Regulatory References

  1. NIH MedlinePlus Drug Information

Eligibility and Restrictions for Use

Eligibility Profile for Flipal (Mefenamic Acid)

Flipal's use is strictly defined by regulatory guidelines that outline which populations are eligible and which are explicitly prohibited from using the medicine.


Contraindicated Populations

Use is contraindicated (absolutely prohibited) for patients with a known hypersensitivity to mefenamic acid, aspirin, or any other Nonsteroidal Anti-inflammatory Drug (NSAID). The medicine is also prohibited in individuals with a history of active ulceration or chronic inflammation of the GI tract, and in those with severe organ failure, including significantly impaired renal function, severe hepatic failure, or severe heart failure. It must not be used for pain management following Coronary Artery Bypass Graft (CABG) surgery.


Age and Reproductive Restrictions

Flipal is authorized for adults and adolescents aged 14 years and older. Regulatory labeling states that safety and efficacy have not been established for children under 14 years of age. Use is absolutely contraindicated during the third trimester of pregnancy (at or after 30 weeks gestation) and is not recommended for women who are breastfeeding or attempting to conceive. The elderly and patients with pre-existing cardiovascular conditions require careful consideration.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Flipal (Mefenamic Acid) has officially documented interaction patterns that necessitate restrictions on co-administration based on regulatory labeling. Use is contraindicated for treating peri-operative pain in the setting of Coronary Artery Bypass Graft (CABG) surgery, and co-administration with other systemic Nonsteroidal Anti-inflammatory Drugs (NSAIDs) should be avoided due to the increased risk of gastrointestinal complications.

Pharmacodynamic and Pharmacokinetic Interactions

The co-administration of Flipal with Oral Anticoagulants (e.g., Warfarin) is documented to enhance the anticoagulant effect and significantly increase the risk of bleeding. Furthermore, Flipal interferes with the anti-platelet effect of low-dose Aspirin.

Flipal affects the clearance of other drugs; for instance, it reduces the renal clearance of Lithium, leading to elevated plasma levels and increased toxicity risk. The drug is metabolized by CYP2C9, meaning co-administration with CYP2C9 inhibitors may cause abnormally high plasma concentrations. Conversely, Magnesium Hydroxide-containing antacids are shown to significantly increase the rate and extent of Flipal's absorption.

Restrictions and Population Notes

The antihypertensive and diuretic effects of medicines like ACE Inhibitors and Diuretics may be reduced, and the combination significantly increases the risk of renal impairment. Consumption of Alcohol may increase the risk of gastrointestinal bleeding. Interaction complications are considered higher for elderly patients and individuals with renal or hepatic impairment due to reduced clearance.

Mechanism of Action

How Flipal Works

Flipal's mechanism is defined by its action as a non-selective inhibitor of the Cyclooxygenase (COX) enzymes, targeting both the constitutive COX-1 and the inducible COX-2 isoforms. This enzymatic blockade prevents the conversion of arachidonic acid into prostanoid mediators, chiefly the prostaglandins.

The resulting reduction in prostaglandin synthesis is responsible for a dual central and peripheral pathway modulation. Peripherally, the decrease in prostanoids reduces the responsiveness of peripheral nociceptors. Centrally, the inhibition of COX activity within the hypothalamus blocks the PGE2 signal responsible for elevating the body’s thermoregulatory set-point . These actions are simultaneous and collectively modulate the targeted physiological pathways.

Additionally, the drug exhibits a secondary action through the direct antagonism or modulation of certain Prostanoid Receptors. This molecular interference provides an additional layer of modulation against prostanoid signaling at the receptor level, supplementing the primary effect of enzymatic blockade.

Dosage and Administration Information

How to Use Flipal (Mefenamic Acid)

Flipal is administered according to specific, short-term regimens detailed in prescribing information, focusing strictly on its use as an oral capsule. The medicine is classified for oral administration only in the form of capsules, typically 250 mg strength, and must be swallowed whole.

Standard Dosing Regimen

Administration follows a two-part dosing schedule for both acute pain and primary dysmenorrhea in adults and pediatric patients 14 years of age. Treatment begins with a higher initial loading dose of 500 mg, followed by a lower maintenance dose of 250 mg taken every six hours (q6h) as needed. The total daily intake, subsequent to the initial dose, should not exceed 1000 mg.

Usage Constraint Requirement
Timing with Meals Must be taken with food or milk to help reduce the potential for gastrointestinal upset.
Duration Limit Therapy must not exceed seven days for acute pain and typically lasts two to three days for menstrual pain.
Pediatric Eligibility Approved for patients 14 years of age and older.

Administration Protocols

For managing menstrual discomfort, the medicine is started at the onset of bleeding or associated symptoms. Guidelines stress adherence to the principle of using the lowest effective dose for the shortest duration necessary to achieve the treatment goal. If a dose is missed, it should be taken when remembered, unless it is almost time for the next scheduled dose, in which case the missed dose must be skipped. The dose should never be doubled.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Flipal


Evidence for Short-Term Relief of Acute Mild to Moderate Pain

Flipal was studied for outcomes related to physical discomfort, including research exploring acute or disruptive episodes such as pain following procedures like dental surgery. The primary research conducted in this area involves short-term Randomized Controlled Trials (RCTs) and systematic reviews. The studies primarily monitored specific measurements of change in pain intensity, using patient-reported scales, and examined the need for rescue analgesic medication.

Studies reported patterns observed in the studies showing a measured change in pain metrics within the first few hours following administration compared to a control. Findings described the time to the onset of a measured change in patient-reported discomfort. The analyzed trials typically described the short-term response over periods of 4 to 6 hours and the use over no more than 7 days in short-course regulatory documentation. What remains uncertain is the scope of these findings for long-term or chronic pain management.


Evidence for Symptoms Associated with the Menstrual Cycle (Primary Dysmenorrhea)

Flipal was evaluated in studies exploring conditions characterized by fluctuating or episodic manifestations, specifically primary dysmenorrhea (painful periods). Research focused on outcomes linked to inflammatory or irritative states and patient-reported outcomes describing perceived discomfort. These trials, including comparative trials, monitored adult women and adolescent females with the condition.

Studies specifically monitored the change in menstrual pain severity and monitored changes in pain duration during the menstrual cycle. Findings generally described the short-term symptomatic response when administered for 2 to 3 days per cycle, starting with the onset of pain. However, there is limited information for long-term outcomes regarding the repeated observation of this medicine over many years.


What Research Gaps and Uncertainties Remain

While the available research helps contextualize how patients reported their experience during acute episodes, limited information for long-term outcomes exists across all indications, as the focus has been intensely short-term. Comparative evidence is lacking for trials matching Flipal against every available standard pain reliever and antipyretic. Additionally, the evidence quality varies across studies, and the findings describe group patterns, which does not determine whether an individual will respond similarly. Further research is still needed to fully characterize the observation of the medicine over time.

Key Studies & References

  1. MEFENAMIC ACID capsule, DailyMed – NIH (FDA Source)
  2. Mefenamic Acid Drug Record – NIH LiverTox
  3. Mefenamic Acid Drug Information (Mechanism) – NIH MedlinePlus
  4. Mefenamic Acid Uses and Indications – NIH MedlinePlus Drug Information

Frequently Asked Questions (FAQ)

Common questions about Flipal (FAQ)

Q: What is the main purpose Flipal is used for?

A: Flipal is officially indicated for the short-term relief of mild to moderate pain. This includes uses such as managing acute pain and pain associated with menstrual cramps (primary dysmenorrhea). Official regulatory information specifies that this medication is approved for patients 14 years of age and older.

Q: Why do people sometimes refer to Flipal by a different name online?

A: Flipal is the brand name for the active drug substance known as Mefenamic Acid. It is common for medications to be known by both a brand name and their generic chemical name. While the original brand (Ponstel) has been discontinued in some markets, the generic form is widely available.

Q: Is Flipal a completely new class of medication?

A: No, Flipal is a member of the class of medications known as Nonsteroidal Anti-inflammatory Drugs (NSAIDs). This is a well-established class of drugs that includes many other common medications used for pain and inflammation.

Q: Is Flipal classified as a controlled substance in any official regulatory documents?

A: According to official regulatory information, Flipal (Mefenamic Acid) is not classified as a controlled substance. This means the medication is not listed as a drug with a high risk of abuse potential by major government regulatory agencies.

Q: Do the most common side effects of Flipal typically lessen after the first few weeks?

A: Official regulatory documents describe side effects by how frequently they occur, but do not make guarantees about whether they will lessen over time. If a common side effect, such as dizziness or drowsiness, persists or becomes bothersome, official guidance suggests that these effects be reported to a healthcare provider.

Q: Is it common to feel tired or fatigued when beginning treatment with Flipal?

A: Yes, drowsiness (somnolence) is listed in official labeling as a common side effect of this medication. Common side effects are generally reported by 1% to 10% of patients who use the drug.

Q: What are the rare but serious side effects that have been noted in official reports about Flipal?

A: Regulatory labeling includes serious warnings about rare but potentially life-threatening risks. These risks include serious cardiovascular (CV) thrombotic events (such as heart attack or stroke), serious gastrointestinal (GI) events (such as bleeding or ulceration), and severe skin reactions.

Q: How frequently do people generally report experiencing a side effect like dizziness while taking Flipal?

A: Official regulatory data lists dizziness as a common side effect of Flipal. This means that, based on clinical studies, dizziness is generally reported by 1% to 10% of patients using this medication.

Q: Is Flipal known to cause weight gain or weight loss in studies?

A: Regulatory information states that unexplained weight gain or swelling (edema) should be reported to a healthcare provider. This is important because such changes may be a symptom of a more serious, documented safety concern related to heart or kidney function.

Q: Does Flipal have a noticeable effect on a person's sleep patterns?

A: Yes, official regulatory data lists both insomnia (trouble sleeping) and somnolence (sleepiness) as documented nervous system side effects. These effects reflect the potential for the medication to influence a person's sleep patterns.

Q: Is an upset stomach or nausea a frequent side effect mentioned for Flipal?

A: Yes, nausea and upset stomach are documented as common side effects. The official labeling indicates that Flipal should be taken with food or milk to help reduce the potential for this type of gastrointestinal upset.

Q: What are the general signs of a severe allergic reaction to Flipal?

A: Signs of a potentially severe allergic reaction listed in official warnings can include difficulty breathing or swallowing and rapid swelling of the face, lips, tongue, or throat. The rapid appearance of hives and severe itching are also key warning signs described in regulatory documents.

Q: Are there any known interactions between Flipal and common herbal supplements or vitamins?

A: Official regulatory documents primarily focus on known drug-to-drug interactions and interactions with alcohol. Because there is no comprehensive list of interactions with every specific herbal supplement or vitamin, for safe use, all products being consumed should be disclosed to a healthcare provider.

Q: Is it generally acceptable to take Flipal with common over-the-counter cold and flu medicines?

A: Regulatory warnings state that Flipal should not be taken with other NSAIDs (Nonsteroidal Anti-inflammatory Drugs). Since many common over-the-counter cold and flu medications contain an NSAID, official warnings emphasize checking active ingredients carefully to avoid taking multiple NSAIDs simultaneously.

Q: Does consuming grapefruit or grapefruit juice have an effect on how Flipal works?

A: Official labeling indicates that the drug is processed by an enzyme in the body called CYP2C9. While the label does not specifically prohibit grapefruit, this fruit is known to interfere with drug-metabolizing enzymes in general. This topic is one that should be discussed with a healthcare provider.

Q: If a person stops taking Flipal, how long does the substance generally stay in the system?

A: The drug has a relatively short elimination half-life of approximately 2 hours. Based on this pharmacokinetic information, most of the active substance is eliminated from the body within about 24 hours after the last dose, although its byproducts may remain longer.

Q: If I miss a dose of Flipal, does it completely stop working?

A: While official dosing guidance provides instructions for a missed dose, the drug is designed for short-term pain relief and has a short half-life. Skipping a dose is likely to reduce the effectiveness of the pain management regimen until the next dose is taken, but the medication is not intended for long-term continuous action.

Q: Is Flipal generally considered suitable for people over the age of 65 or the elderly?

A: Regulatory information notes that elderly patients are at greater risk for serious side effects, specifically gastrointestinal and cardiovascular events. Official labeling advises that healthcare providers should carefully consider the risks and benefits for individuals over 65 years of age.

Q: Are there any specific pre-existing health conditions that are official contraindications for Flipal use?

A: Yes, the official labeling lists several health conditions where Flipal must not be used (contraindications). These include a history of allergic reactions to aspirin or other NSAIDs, active GI bleeding or ulceration, and use for pain immediately following Coronary Artery Bypass Graft (CABG) surgery.

Q: Can women who are pregnant or are trying to become pregnant use Flipal?

A: The official label advises avoiding use after 20 weeks of pregnancy due to risks to the fetus, and the drug is contraindicated (prohibited) in the last three months of pregnancy. Official information also notes the drug may temporarily make it more difficult for a woman to become pregnant.

Q: Is it possible to use Flipal while breastfeeding?

A: Official regulatory guidance notes that the drug passes into breast milk. Because there is a potential for serious adverse reactions in nursing infants, official documentation states that a decision should be made regarding whether to discontinue nursing or discontinue the medication.

Q: Does having impaired kidney function affect a person's eligibility to use Flipal?

A: Yes, Flipal is contraindicated (must not be used) in patients with pre-existing renal disease or significantly impaired kidney function. This restriction exists because the kidneys are the primary way the body eliminates the drug and its byproducts.

Q: Can Flipal be used by someone who has mild liver impairment?

A: Official regulatory labeling advises that dose adjustments may be required for patients who have existing liver dysfunction. Caution is recommended, and there may be a requirement to discontinue the medication if laboratory tests show signs of developing or worsening liver disease.

Q: Where can a patient find the official summary of research evidence for Flipal?

A: Official summaries of the clinical studies, safety data, and regulatory labeling for Flipal are published on government-run portals. Examples include the FDA's Drugs@FDA database, the NIH DailyMed site, or public assessment reports from other major health authorities.

Q: Is Flipal considered to be an addictive or habit-forming medication?

A: No, Flipal is classified as an NSAID and is not listed as a drug with abuse potential by official regulatory agencies. It is not considered an addictive or habit-forming medication.

Q: Does Flipal contain any ingredients that cause sedation or drowsiness?

A: Yes, the active ingredient in Flipal is associated with drowsiness (somnolence) and dizziness. These are listed as common side effects affecting the nervous system in official regulatory documents.

Q: Why is a specific lab test sometimes required before a person can start taking Flipal?

A: Healthcare providers may require monitoring of renal (kidney) and hepatic (liver) function through lab tests. This monitoring is advised in regulatory labeling, particularly for patients using the drug for longer periods or who have pre-existing conditions, to check for potential toxicity.

Q: Is a generic version of Flipal currently available on the market?

A: Yes, the drug is widely available under its generic name, Mefenamic Acid. Official regulatory documents and market information confirm that the generic form is commonly prescribed and dispensed.

Q: Does Flipal affect the results of routine medical tests?

A: Yes, regulatory data indicates that Flipal has been reported to interfere with certain clinical laboratory tests. Specifically, it may cause a false-positive result for certain substances, such as bile, in urine tests.

Q: Can Flipal be taken alongside vitamins or minerals without issue?

A: Official regulatory documents focus on known interactions with other prescription drugs and alcohol. Since there is no exhaustive list covering every specific vitamin or mineral, for safe use, all nutritional supplements being taken should be disclosed to a healthcare provider.

How should Flipal be stored and disposed of?

Flipal (Mefenamic Acid capsules) must be stored and disposed of according to strict regulatory guidelines to maintain its quality and prevent accidental exposure.

Official Storage Requirements

Condition Regulatory Mandate
Temperature Store at controlled room temperature (15 C to 30 C).
Protection Keep away from excess heat, moisture, and direct light.
Container Must be kept in the original container and kept tightly closed.
Child Safety Store the medicine out of the reach of children and pets.

Official Disposal Instructions

Disposal of unused or expired Flipal should utilize a formal drug take-back program when available. If take-back is not an option, the medicine must be prepared for household trash by mixing the contents with an undesirable substance, such as coffee grounds, before sealing and discarding. The capsules must not be flushed down the toilet or poured down a drain.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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