Eprecis

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Eprecis

Method of action: Endectocides

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Eprecis

Property Description
Active ingredient Eprinomectin
Form Solution for injection, Pour-on solution
Pharmacological class Endectocide (Macrocyclic Lactone)
General purpose Comprehensive control of parasitic infestations
Origin Semi-synthetic

What Kind of Medicine is Eprecis?

Eprecis is a veterinary medicinal product classified as an endectocide, which is a high-level designation for an agent that simultaneously targets internal and external parasites in livestock. This classification underscores its broad-spectrum antiparasitic capability, as it is effective against both endoparasites (internal worms) and ectoparasites (skin parasites). The general purpose of Eprecis is to provide comprehensive control of parasitic infestations in species such as cattle and sheep, and is clinically recognized for its efficacy in reducing parasitic loads.


Composition and Type: The Eprinomectin Core

The efficacy of Eprecis is centered on its single active ingredient, Eprinomectin, which belongs to the potent macrocyclic lactone class of antiparasitic agents. This substance is a semi-synthetic compound derived from the avermectin family. Eprecis is supplied in two primary dosage forms for systemic absorption: a solution for injection for subcutaneous injection, and a pour-on solution for topical application. This flexibility in presentation is a key differentiating factor, allowing veterinarians to choose the administration route best suited for the animal's specific needs.


How Does Eprecis Work at a High Level?

Eprecis achieves its effect through a specific action on the parasite's nervous system. Eprinomectin works by selectively targeting and disrupting unique channels (glutamate-gated chloride ion channels) found exclusively in the parasite's nerve and muscle cells. This action leads to a rapid state of paralysis and death of the organism. This specific physiological action ensures the compound’s potency as an endectocide against both internal and external parasitic stages.

What side effects are possible with Eprecis?

Possible side effects and safety information

The safety profile for Eprecis is defined by adverse reactions related to its administration methods and high-level toxicity concerns related to its pharmacological class, macrocyclic lactones, as documented in regulatory sources.

Official Adverse Reaction Classification

The frequency of adverse reactions is classified according to standard regulatory conventions:

Classification Type of Reaction (System-Organ Class)
Common General Disorders: Local transient reactions, such as swelling or oedema, at the injection site (for injectable forms). These reactions typically resolve without specific treatment.
Uncommon Skin and Subcutaneous Tissue Disorders: Transient skin reactions, including pruritus (itching) or erythema (redness), often observed after topical (pour-on) application.
Rare Nervous System Disorders: Severe neurological signs, such as ataxia (loss of coordination) or tremors, are generally associated with doses significantly exceeding the recommended level.

Serious Safety Events and Restrictions

Certain serious events and safety constraints are explicitly documented in regulatory labeling:

  • Host-Parasite Reactions: The destruction of migrating parasite larvae, such as Hypoderma (cattle grubs), when located near vital structures like the esophagus or spinal column, can cause severe host reactions, including bloat, staggering, or paralysis.
  • Fatal Toxicity: The product is strictly contra-indicated for use in non-target species, including dogs (especially Collie-related breeds susceptible to avermectins) and turtles/tortoises, due to the high risk of fatal neurological toxicity.
  • Population Restriction: Use is restricted in calves less than 3 months of age and in animals with known hypersensitivity to Eprinomectin.
  • Residue and Environmental Constraints: Mandatory withdrawal periods must be observed before treated animals are slaughtered for human consumption. Furthermore, the active substance is documented as very toxic to dung fauna and aquatic organisms, necessitating environmental safety precautions.

The regulatory framework ensures that the most frequent effects are transient and localized, while the potential for serious reactions is explicitly contained by constraints on use in specific species and in cases of overexposure.

Overdose and Emergency Response

Overdose and when to seek help

The official product information for Eprecis (Eprinomectin) defines the risks of overdose and accidental exposure in both target animals and humans.


Documented Overdose Findings in Target Species

Official regulatory studies show a high safety margin in target animals. After subcutaneous administration of up to five times the recommended dose in cattle and sheep, no adverse systemic effects were observed.

Documented Manifestation
Transient, localized swelling at the injection site.
Induration (hardness) at the injection site (may persist).

Risks and Required Emergency Actions

The most serious documented risks are related to accidental exposure, necessitating immediate action.

  • Accidental Human Exposure: The label warns that accidental self-injection or ingestion may cause neurotoxicity. If this occurs, the exposed person must seek medical advice immediately and show the package leaflet or the label to the physician.
  • Non-Target Species Risk: The drug's class (avermectins) is associated with fatalities in certain animal species, specifically dogs (Collies, Old English Sheepdogs, and related breeds) and turtles/tortoises. The product is strictly not to be used in these species.
  • Goat Safety: Overdose studies have not been demonstrated for safety in goats.

Therapeutic Uses of Eprecis

What Eprecis treats: main uses and benefits

Eprecis is a veterinary medicinal product commonly used across conditions presenting with acute episodes of parasitic infestations in cattle, sheep, and goats. The main therapeutic domain is used in situations involving certain distressing symptoms caused by internal and external parasites that are sensitive to the active substance, eprinomectin. The product is relevant for easing symptoms linked to common livestock parasites.

Specifically, it is used for managing symptoms related to major internal infestations, such as gastrointestinal roundworms and lungworms, and is applied in addressing common external parasites in cattle, including sucking lice, horn flies, warbles (parasitic stages), and mange mites. The application of Eprecis is often used during phases when symptoms become more noticeable. By addressing these infestations, the product may assist with easing the overall symptom burden that can lead to systemic imbalance and noticeable physiological strain in the animals. The product supports the general well-being of the livestock by providing supportive relief during these periods of heightened symptoms.

“The primary goal of Eprecis is to offer symptomatic relief and support to animals experiencing discomfort associated with parasitic burden.”

Quick Fact: Relief for Physical Discomfort The product is applied in addressing conditions where symptoms create noticeable functional strain related to both internal and external parasitic activity.

Regulatory References

  1. Summary of Product Characteristics (SPC) from the UK's Veterinary Medicines Directorate

Eligibility and Restrictions for Use

Eprecis (Eprinomectin) is a veterinary medicinal product with strict population eligibility rules defined by official regulatory documentation. Its use is limited to the designated target species of cattle, sheep, and goats.

Contraindicated Populations

Use is strictly contraindicated in several groups. The medicine must not be administered to any animal species other than the target species. Specifically, it is prohibited in dogs (especially avermectin-sensitive breeds like Collies) and turtles/tortoises. Additionally, Eprecis is contraindicated in animals with a known hypersensitivity to the active substance, Eprinomectin.

Conditional and Restricted Use

While generally permitted in cattle, use is restricted by reproductive status in others. The medicine can be used during pregnancy and lactation in cattle without restriction. However, safety during pregnancy and lactation in sheep and goats has not been established and requires a formal benefit/risk assessment by a veterinarian before use. Conditional use also applies to cattle with Hypoderma larvae (warbles), requiring treatment within a specific, prescribed time window to prevent potential adverse reactions.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation for Eprecis (Eprinomectin) outlines one primary pharmacokinetic consideration concerning co-administration with other medicinal products.

Pharmacokinetic Interaction (Protein Binding Competition)

Eprinomectin is documented to bind strongly and extensively to plasma proteins. This characteristic is the basis for a potential interaction with other medicines. When Eprecis is administered concurrently with other drugs that also exhibit strong plasma protein binding, regulatory guidelines require that this potential for competition be taken into account, as it may affect the exposure, or free concentration, of either substance in the plasma.

Formal Absence of Other Documented Interactions

Interaction classifications are based on explicit statements within government-approved drug labels:

  • Contraindicated Combinations: No medicinal products are formally classified in the official regulatory labeling as contraindicated for co-administration due to interaction risk.
  • Metabolic Interactions: The official profile does not specify any interacting substances that affect Eprinomectin via cytochrome P450 (CYP) enzymes or major drug transporters.
  • Timing Requirements: The regulatory documents do not specify any mandatory timing-based interaction rules, such as requiring a minimum separation in administration time between Eprecis and other medicines.
  • Food/Substance Interactions: No specific interactions with food, alcohol, herbal products, or supplements are documented within the official government prescribing information.

Mechanism of Action

Selective Disruption of Invertebrate Chloride Channels

Eprecis works by targeting the glutamate-gated chloride ion channel ( GluCl), a unique molecular structure found in the nerve and muscle cells of invertebrate parasites. The active ingredient, Eprinomectin, acts as an allosteric modulator that locks these channels open, causing a continuous influx of chloride ions ( Cl^-). This action initiates the cellular cascade by driving the parasite's excitable cells into a state of hyperpolarization.


Causal Cascade Leading to Flaccid Paralysis

The sustained hyperpolarization blocks all necessary signaling within the parasite's neuromuscular pathway. This suppression of nerve-to-muscle communication leads directly to flaccid paralysis of the somatic and pharyngeal musculature. The mechanism exhibits target specificity, as the mammalian host lacks this high-affinity GluCl target, while poor blood-brain barrier penetration limits the mechanism's action on the host's central nervous system.

Dosage and Administration Information

How Eprecis is Used: Official Administration Guidelines

Eprecis, containing the active ingredient Eprinomectin, is administered as a single treatment using one of two approved methods: a Pour-on solution for topical application or a Solution for injection for subcutaneous use. The choice of method dictates the specific dosing rate and required administration procedure.


Administration Routes and Dosing

Formulation Approved Route Standard Dosing Regimen
Pour-on Solution (5 mg/mL) Topical application 0.5 mg eprinomectin per kg body weight, corresponding to 1 mL per 10 kg body weight.
Injection (20 mg/mL) Subcutaneous injection 0.2 mg eprinomectin per kg body weight, corresponding to 0.1 mL per 10 kg body weight.

Both forms are intended for single administration only, and repeated use should be avoided to manage the risk of developing parasite resistance.


Essential Procedural Instructions

Accurate dosing is a critical procedural requirement. Body weight must be determined as accurately as possible, and the dosing device (such as a calibrated dosing gun or cup) must be checked for precision to ensure the correct volume is administered. Underdosing is specifically restricted due to its association with ineffective treatment and the promotion of resistance.

For the Pour-on solution, application is restricted to a narrow strip along the backline, extending from the withers to the tailhead. It is explicitly instructed not to apply the solution to areas of the backline that are covered with mud or manure. The Pour-on solution is not to be administered orally or by injection. Similarly, the Solution for Injection is not for oral, intravenous, or intramuscular use.

Eprecis Pour-on is approved for use in lactating dairy cattle. The injection volume per site in goats must not exceed 0.6 mL.

Recent Clinical Evidence

Research evidence / Overview of studies for Eprecis

The research supporting the use of Eprecis is primarily based on controlled veterinary studies that examined its activity against various parasitic infestations in livestock. The body of evidence focuses on determining how the active ingredient, eprinomectin, relates to parasite populations and how animal health indicators evolve during and after periods of research. This overview is based on findings reported to governmental and intergovernmental regulatory bodies.


Evidence for Internal Parasites (Gastrointestinal Roundworms and Lungworms)

Study Design and Measured Outcomes

Research examining Eprecis's activity against internal parasites, such as gastrointestinal roundworms and lungworms, was evaluated in controlled settings, including Randomized Controlled Trials (RCTs). The main focus of these studies was on defined biological measurements, specifically the change in parasite counts (fecal egg counts and total worm counts). Studies also monitored production metrics, such as changes in body weight gain and daily milk yield, and they monitored re-infestation rates over defined time intervals.

What the studies reported

The controlled trials reported measurements that described the percentage change in both egg and total worm counts across the livestock populations observed. Research evaluated changes measured during the study period, monitoring patterns related to the presence of internal parasites that were tracked. Findings describe patterns observed in the studies that related to changes in weight gain or milk yield in the groups studied compared to control groups in certain trials.


Evidence for External Parasites (Lice, Horn Flies, and Mites)

Research also explored the activity of Eprecis against external parasites, including sucking lice, horn flies, and mange mites, primarily using Controlled Field and Laboratory Trials. Researchers monitored change in external parasite counts and the duration of the product's insecticidal activity. Research explored various application protocols for these smaller ruminants, particularly when addressing infestations like mange mites.


What is Still Uncertain About the Research

The evidence base is substantial for the primary species, cattle, reflecting a large number of controlled trials. However, there are areas where data are limited and certainty remains uncertain. Specifically, there is a lack of long-term information regarding the cumulative activity of repeated use. Additionally, the core research describes certain patterns of activity in the trial settings, but the activity may vary in field settings where anthelmintic resistance has developed.

Key Studies & References

  1. SUMMARY OF PRODUCT CHARACTERISTICS: Eprecis 20 mg/ml solution for injection for cattle, sheep and goats
  2. SUMMARY OF PRODUCT CHARACTERISTICS: Eprecis 5 mg/ml pour-on solution for cattle, sheep and goats

Frequently Asked Questions (FAQ)

Common questions about Eprecis (FAQ)


Q: Does Eprecis have a 'black box' warning, and what does it mean?

Official product labeling contains prominent warnings and restrictions regarding its use. These include strict contraindications (reasons not to use the drug) for certain non-target species (like dogs and turtles) associated with the potential for fatal neurological toxicity (serious nervous system harm). Warnings also address serious host reactions if specific parasite larvae are located near critical structures like the spinal cord.


Q: What is Eprecis used for, besides the primary approved use?

Regulatory documents state that Eprecis is indicated exclusively for the treatment and control of specified internal and external parasitic infestations in the designated target species (cattle, sheep, and goats). Official labeling does not include information on or define any other uses beyond these approved indications.


Q: Are the side effects of Eprecis usually temporary or long-lasting?

According to official documents, the most common adverse reactions, such as swelling at the injection site or skin redness from the pour-on, are classified as local transient reactions. This means they are localized, temporary, and typically resolve on their own without needing specific treatment.


Q: Does taking Eprecis affect sleep or cause insomnia?

The official classification of side effects lists serious neurological signs, such as ataxia (loss of coordination) or tremors, associated generally with doses exceeding the recommended level. However, insomnia or other specific sleep disturbances are not listed or categorized among the common, uncommon, or rare adverse reactions in the official product labeling.


Q: Does Eprecis interact with over-the-counter pain relievers like ibuprofen or acetaminophen?

The official interaction profile states that the active ingredient, Eprinomectin, binds strongly to plasma proteins and warns of potential competition with other medicines that also bind strongly. Specific interactions with common human over-the-counter pain relievers are not addressed or specified in the official regulatory documents.


Q: Can Eprecis cause changes in mood or anxiety levels?

The regulatory documents classify adverse reactions involving the nervous system, typically associated with high doses. These effects are described as physical neurological signs (like ataxia or tremors). Changes in mood or anxiety levels are not listed as specified adverse reactions in the official product labeling.


Q: Is Eprecis a habit-forming or addictive medicine?

Eprecis is officially classified as a veterinary endectocide belonging to the macrocyclic lactone class of antiparasitic agents. It is not classified by regulatory bodies as a controlled or scheduled substance, and the official classification does not associate it with a risk of addiction or habit-forming properties.


Q: What happens if a dose of Eprecis is missed?

The regulatory text for Eprecis specifies that the product is intended for single administration only per treatment cycle. Because of this requirement, the official labeling does not include instructions regarding the management or handling of a missed dose.


Q: Why do some people experience fatigue when taking Eprecis?

Official regulatory documents categorize side effects by frequency (common, uncommon, rare) based on clinical data. Fatigue is not listed or categorized among the adverse reactions described in the official product labeling.


Q: Do older adults (seniors) have a different experience with Eprecis?

Regulatory documents address safety considerations for specific sensitive populations, such as very young calves. Official information does not specify any unique safety precautions or different experiences related to the use of Eprecis in older adult animals.


Q: Is Eprecis more effective when taken at a specific time of day?

The official product documentation provides requirements for dosing based on body weight, administration route, and dose volume. However, it does not specify any mandatory timing requirements related to the time of day for administration to maximize effectiveness.


Q: Can Eprecis be taken with other prescription medicines for the same condition?

Regulatory warnings explicitly advise against the use of macrocyclic lactone products, like Eprecis, with short intervals between treatments. This precaution is advised due to the risk of contributing to the development of anthelmintic resistance (a population-level issue) in the parasite population.


Q: How common are allergic reactions to Eprecis?

Known hypersensitivity to the active substance, Eprinomectin, is listed as a contraindication (a reason to avoid use). While this risk is noted, the official regulatory classification of adverse reactions does not specify a frequency (Common, Uncommon, or Rare) for general allergic reactions.


Q: Does Eprecis require special monitoring from a healthcare professional?

Official instructions mandate that the user accurately determine body weight and use a calibrated dosing device to prevent underdosing, which is critical for safety and effectiveness. The label does not require any other specific routine medical monitoring tests.


Q: What do people commonly misunderstand about how Eprecis works?

The official mechanism of action notes the compound’s action on the parasite's nervous system. It notes the drug’s target specificity, explaining that the mammalian host lacks the high-affinity molecular target found in the parasites, a feature that limits its effect on the host.


Q: Is it possible to develop a tolerance to Eprecis over time?

Regulatory documents do not discuss tolerance in an individual patient. Instead, official information focuses on the risk of promoting anthelmintic resistance in the parasite population if the product is repeatedly used or if underdosing occurs.


Q: What is the molecular target of Eprecis, as described in official documents?

Official documents describe the compound's mechanism by defining its molecular target. This target is the glutamate-gated chloride ion channel (GluCl), which is found in the nerve and muscle cells of invertebrate parasites and is selectively locked open by the active ingredient.


Q: Does Eprecis affect blood pressure or blood sugar levels?

Official safety data lists adverse reactions related to general disorders and the nervous system. However, the product labeling does not classify specific effects on blood pressure (cardiovascular) or blood sugar (metabolic) levels as a common, uncommon, or rare side effect.


Q: Does Eprecis impact the effectiveness of birth control pills?

The official regulatory profile concerns veterinary use and does not contain any documented information or assessment regarding specific interactions with human hormonal products, such as birth control pills.


Q: How long does Eprecis stay in the body after the last dose?

Pharmacokinetic data indicates that the active ingredient is primarily excreted through feces. For some formulations, low levels of the drug may remain in the system for up to 180 days or more. The long duration is a factor in the mandatory withdrawal periods that must be observed before the animal can be used for human consumption.


Q: Is there a maximum time someone can safely use Eprecis?

The regulatory documents specify the product is intended for single administration only per treatment cycle and do not define an official maximum safe time limit for continuous or chronic use.


Q: Are there generic versions of Eprecis available?

Regulatory databases list multiple approved products containing the active ingredient Eprinomectin, often marketed under different names by various manufacturers. This indicates that other approved products containing the same active ingredient, Eprinomectin, are available.


Q: Are there documented cases of overdose with Eprecis, and what happened?

Regulatory documents indicate that administering doses significantly exceeding the recommended level is associated with the potential for severe adverse neurological signs. These signs may include ataxia (loss of coordination) or tremors.

How should Eprecis be stored and disposed of?

How to Store and Dispose of Eprecis?

Eprecis (eprinomectin) must be stored and handled according to specific regulatory requirements to maintain product stability and protect the environment.


Storage and Stability Rules

Requirement Specific Condition
Temperature Store between 15°C and 30°C and protect from light.
In-Use Shelf-Life Use the Pour-On Solution within 6 months after the container is first opened.
Container Rule Injection vials (250/500 mL) must not exceed 20 stopper piercings (broachings).
Child Safety Keep out of the sight and reach of children and animals.

Disposal Instructions

Unused or expired product must be disposed of safely in accordance with local regulatory requirements. Eprinomectin is highly toxic to aquatic organisms, and therefore, the product and its waste must not contaminate streams, rivers, or waterways.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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