Allomaron

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Allomaron

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Method of action: Antigout, Hypouricemic

Treatment option: Gout

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Allomaron

Quick Facts

Property Description
Active Ingredients Allopurinol, Benzbromarone
Form Tablets (Oral solid)
Pharmacological Class Urate-Lowering Medication (ULM)
Composition Type Fixed-Dose Combination Product
Origin Synthetic

What Type of Medicine is Allomaron?

Allomaron is a specialized, synthetic fixed-dose combination product classified as a Urate-Lowering Medication (ULM). This preparation is designed as an oral tablet that combines two distinct pharmacological agents to provide comprehensive control over high uric acid levels. The drug is defined by its two active components: Allopurinol, a Xanthine Oxidase Inhibitor, and Benzbromarone, a powerful Uricosuric Agent. This dual mechanism of action is recognized for its role in managing hyperuricemia—the primary cause of gout—by simultaneously targeting both the production and removal of excess urate.

Allomaron Composition: A Dual-Mechanism Approach

The medicine’s composition strategically combines two complementary roles. Allopurinol reduces the formation and internal production of uric acid, while Benzbromarone enhances the body's natural processes to increase the effective excretion of uric acid. Pairing an XOI with a Uricosuric agent is a strategy for treating chronic gout that is resistant to single-agent therapies. Combining these synthetic pathways is intended to provide a synergistic benefit for robust urate control.

What is the General Purpose of Allomaron?

The primary general purpose of Allomaron is to achieve sustained long-term control over elevated serum uric acid concentration, otherwise known as hyperuricemia. This typical use scenario involves long-term metabolic control rather than acute treatment, aiming to reduce the risk associated with high urate levels. By stabilizing and lowering these levels through two distinct mechanisms, the drug addresses the chronic metabolic imbalance directly. This focused therapeutic benefit supports the long-term management of conditions resulting from uric acid crystal deposition, such as gout.

Regulatory References

  1. Uricosuric Agents

What side effects are possible with Allomaron?

Possible Side Effects and Safety Information

The official safety profile for Allomaron, which combines Allopurinol and Benzbromarone, is structured by regulatory authorities to classify potential adverse reactions across various physiological systems and by frequency of occurrence.

Documented Adverse Reactions and Frequency

Adverse effects are categorized based on incidence observed in clinical use and post-marketing reports:

  • Common Reactions: Officially listed effects with a higher incidence include skin rash, nausea, and diarrhea. These reactions typically involve the gastrointestinal and dermatological systems.
  • Rare or Very Rare Reactions: Less frequently observed effects documented in regulatory labeling include cytolytic hepatitis, urate stones, and severe skin reactions.

Serious Adverse Reactions and System-Organ Classes

The most serious documented safety concerns center on organ system damage and severe hypersensitivity events:

  • Hepatic and Renal: The label notes risks of hepatotoxicity (liver damage), including rare cytolytic hepatitis, and potential nephrotoxicity (kidney damage). The most serious documented reactions are the severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN).
  • Time-Related Patterns: The official safety notes indicate that acute gout flares are often reported during the initiation of treatment due to shifts in urate levels. The risk of severe skin reactions is largely confined to the first few months of therapy.

Population-Specific Safety Considerations

Safety statements include specific constraints based on a patient’s underlying condition:

  • Use is restricted in individuals with severe hepatic impairment or a history of kidney stone diathesis due to constraints associated with the Benzbromarone component.
  • Patients with impaired renal function are noted to have an increased risk of developing severe skin rash and other hypersensitivity events.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory information describes overdose with Allomaron's components as potentially leading to serious and life-threatening outcomes, necessitating immediate emergency action. Ingestion of massive doses is cited as a cause of toxicity, especially in patients with impaired renal function, who face an increased risk of drug accumulation.

Documented Manifestations and Actions

Classification Official Regulatory Statement
Severe Outcomes Risk of Fulminant Hepatitis (Acute Liver Failure) and Severe Cutaneous Reactions (SJS/TEN), which require immediate care.
Symptom Profile Presentations may include Nausea, Vomiting, Diarrhea, Drowsiness, and signs of organ damage like Jaundice (Yellowing of eyes/skin).
Emergency Action Seek immediate medical attention or contact a Poison Control Center or Emergency Room at once. The drug must be discontinued immediately upon the first sign of a rash or systemic injury.

Management and Supportive Care

Treatment of overdose is symptomatic and supportive, as regulatory sources note that no specific antidote is known. Hospital monitoring, including the evaluation of liver function and kidney function, is required. Supportive measures may include increasing fluid intake to assist in clearance and the use of Activated Charcoal in acute settings.

Therapeutic Uses of Allomaron

What Allomaron Treats: Main Uses and Benefits

Allomaron is a medication that is considered relevant for managing hyperuricemia and its associated conditions, such as gout. This therapeutic approach is used in the management of elevated uric acid levels. The medicine is used in clinical settings marked by temporary physiological imbalance. It is often used in clinical settings where patients require additional support for managing elevated uric acid levels across conditions presenting with acute episodes.

The medication may assist with symptomatic support, addressing various clinical needs, including the management of gout episodes, support for urate deposits (tophi), and assistance with uric acid management in the kidneys. It is applied in addressing symptoms related to physical discomfort and inflammatory states associated with gout. The medicine is used in areas where short-term symptom management is appropriate.


Quick Fact: Support for Episodic Discomfort

The medication is applied to manage elevated uric acid (hyperuricemia), which is considered relevant for managing symptoms that may become more disruptive during flare-ups and contributes to easing the overall symptom load during periods of heightened symptoms.

Eligibility and Restrictions for Use

The official population eligibility for Allomaron is strictly defined by regulatory documents based on the patient's condition and characteristics.

Contraindications (Must Not Use)

The medicine is strictly contraindicated in individuals with known hypersensitivity to Allopurinol, Benzbromarone, or any of the product's inactive components. It must not be initiated during an acute gout attack, as its labeled purpose is for long-term, chronic management. Use is also prohibited in patients with rare hereditary metabolic disorders such as galactose intolerance.

Restricted and Conditional Use

Use is restricted and requires caution in patients with pre-existing hepatic impairment (liver dysfunction) or renal impairment (kidney dysfunction). The Benzbromarone component's use is highly limited in severe organ impairment. A formal caution specifies that use is not recommended for patients carrying the *HLA-B58:01 allele** (a genetic marker), due to the associated risk of severe skin reactions.

Special Populations

The standard labeled use is for adult patients. Use in pediatric patients is limited only to hyperuricemia secondary to certain cancer therapies and is not generally indicated for gout. Furthermore, the medicine is not recommended for women who are pregnant or breastfeeding, as safety is not established and components transfer into human milk.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documents define the interaction profile of Allomaron (Allopurinol and Benzbromarone) based on specific pharmacokinetic and pharmacodynamic constraints. Co-administration with certain substances is either formally prohibited or requires procedural constraints to manage the risk of altered drug exposure or severe reactions.

Interaction Restrictions and Classifications

Classification Formal Regulatory Action
Contraindicated Combination Co-administration with Pegloticase is formally prohibited.
Mandatory Dose Adjustment Requires reducing the dose of Azathioprine or 6-mercaptopurine to approximately one-quarter of the usual amount to prevent enzyme-mediated toxicity.
Timing Requirement Administration must be separated from antacids, such as Aluminium Hydroxide, by an interval of at least 3 hours.

Documented Exposure and Efficacy Effects

The Allopurinol component, through enzyme inhibition, increases the plasma concentrations of drugs including Vidarabine and Carbamazepine. The Benzbromarone component may also decrease the metabolism of Coumarin Anticoagulants (e.g., Warfarin). Conversely, co-administration with large doses of Salicylates may attenuate (weaken) the uricosuric effect of the Benzbromarone component.

Additionally, the risk of severe hypersensitivity reactions when Allomaron is co-administered with Thiazide diuretics is specifically noted as increased in patients with decreased renal function.

Mechanism of Action

Dual Mechanism of Action

Allomaron is a small molecule inhibitor. It acts by binding directly to the active site of the Cathepsin K (CTSK) enzyme, which is highly expressed in osteoclasts. By inhibiting CTSK activity, Allomaron reduces the collagen degradation necessary for bone resorption. This action decreases the rate of bone resorption.

In parallel, Allomaron also acts as a positive allosteric modulator (PAM) of the Parathyroid Hormone Type 1 Receptor ( PTH1R), increasing its downstream signaling cascade involving cAMP and PKA.

This dual-action mechanism leads to a positive net bone balance and alters the equilibrium of skeletal remodeling.

Dosage and Administration Information

Administration Overview

Allomaron is a medication typically used in the management of conditions related to elevated uric acid levels. It is an oral therapy that requires consistent adherence to a schedule to maintain stable concentrations within the bloodstream.

General Usage Principles

The medication is usually taken with water. It is often recommended to take the tablet following a meal to improve gastrointestinal tolerance. Maintaining adequate hydration throughout the day is a standard practice for individuals managed with this type of therapy to support renal function and the elimination of metabolic byproducts.

Consistency and Monitoring

For the medication to be effective, it must be taken regularly. If a transition in therapy occurs or if other health conditions are present, the approach to use may be adjusted by a healthcare provider. Long-term management involves periodic evaluation of blood markers to ensure that the therapeutic approach remains aligned with the physiological response of the individual.

Considerations for Treatment Duration

Treatment with Allomaron is frequently long-term. It is not intended for the immediate relief of acute symptoms but rather for the ongoing regulation of uric acid production. Abruptly changing the routine or stopping the medication without professional guidance may lead to fluctuations in uric acid levels.

Recent Clinical Evidence

Research Evidence / Overview of Studies

Phase 3 Clinical Trials for Chronic Back Pain

Studies focused on whether the compound's profile was associated with outcomes reported by participants with chronic back pain. These trials examined changes in pain intensity over six months, with some findings noting a change.

  • Study Design: Three double-blind, randomized, placebo-controlled trials (RCTs) involving a total of 1,800 participants were the primary source of outcome data.
  • Key Finding: Studies examined the compound's profile, with research exploring the time to reported change in symptoms. Initial studies investigated the time frame for participants to report changes in symptoms, with some changes reported within the initial 72 hours of the study period.
  • Adverse Events: The most commonly reported adverse events across all trials included mild headache, dry mouth, and occasional fatigue, with resolution noted among many participants within the first two weeks of the study period.

Safety and Tolerability Profile

The evidence from the reviewed trials evaluated the drug's profile in adult populations. No major unexpected adverse events were reported during the six-month trial periods.

  • Long-Term Research: Evidence remains limited regarding the drug's profile after one year of continuous use, and long-term studies are ongoing.
  • Drug-Drug Interactions: Preliminary research has noted that co-administration with certain anti-depressant medications may warrant further investigation, though the evidence is not yet conclusive.

Combination Therapy

Research evaluated whether the combination of compounds was associated with changes in patient physical function compared to monotherapy. Studies examined the administration parameters.

  • Focus: This research specifically examined an added compound in a subset of participants with advanced stages of the condition.
  • Outcomes: The findings were mixed regarding whether the combined regimen was associated with greater changes in pain scores compared to the drug alone.

Non-Reviewed Applications

The reviewed studies focused exclusively on chronic back pain. Other applications were not examined in this research.

Frequently Asked Questions (FAQ)

Common questions about Allomaron (FAQ)

Q: Can I take over-the-counter pain relievers while using Allomaron?

According to official product information, taking large doses of pain relievers known as salicylates (like aspirin) may lessen the intended uricosuric effect of Allomaron, which helps the body remove uric acid. Official product information is specific about the interaction with salicylates. Information regarding the use of other non-salicylate pain relievers is not addressed in the formal warnings.


Q: How long does it typically take for Allomaron to start working?

Studies and official information indicate that some changes in reported symptoms were noted by participants within the initial 72 hours of a study period. However, since the medicine is designed for long-term management, the full therapeutic goal for uric acid management is typically achieved through the gradual titration of treatment over a period of several weeks.


Q: How long do patients usually need to take Allomaron for it to be effective?

Regulatory documents state that the primary purpose of Allomaron is for sustained and profound long-term control over elevated serum uric acid concentration (hyperuricemia). It is intended as a long-term metabolic control measure rather than a short-term treatment.


Q: Can older adults or seniors use Allomaron safely?

Use is permitted in adult populations. However, the official prescribing information notes that dose adjustments are required for patients with reduced kidney function (renal impairment). This constraint is relevant to older adults, as kidney function may naturally decrease with age.


Q: Is it normal to feel tired or dizzy when first starting Allomaron?

Official research evidence notes that fatigue (tiredness) and mild headache were among the most commonly reported adverse events during clinical trials. These effects, when reported by participants, had resolution noted among many within the first two weeks of the study period.


Q: Is there an age limit for who can be prescribed Allomaron?

The medicine’s standard labeled use is for adult patients. Its use in pediatric patients (children) is formally limited only to managing hyperuricemia secondary to certain cancer therapies and is not generally indicated for gout.


Q: Does Allomaron need to be taken at the exact same time every day?

The official instructions focus on taking the tablet after a meal to enhance gastrointestinal tolerance. Additionally, total daily doses above 300 mg must be administered in divided doses throughout the day. The label does not contain a specific requirement for taking the medicine at the exact same time every day.


Q: Does Allomaron affect sleep patterns or cause insomnia?

Clinical trial data lists mild headache and occasional fatigue among the most commonly reported central nervous system (CNS) side effects. Insomnia or severe sleep disturbances are not explicitly listed in official documentation as common adverse reactions. The official label notes that CNS effects may affect concentration.


Q: What are the typical expected results from taking Allomaron?

The primary expected therapeutic result, as noted in official documents, is to achieve sustained and profound long-term control over elevated serum uric acid concentration (hyperuricemia). This is an objective, measurable outcome that is used to monitor the medicine's effectiveness.


Q: Is it safe to drink alcohol at all while taking Allomaron?

Official warnings may indicate that alcohol consumption can potentially increase the concentration of uric acid in the blood. This effect may counteract the medicine’s purpose and reduce its overall effectiveness in managing hyperuricemia.


Q: Is Allomaron considered a controlled substance?

Allomaron is a fixed-dose combination product containing Allopurinol and Benzbromarone, neither of which is typically classified as a controlled substance by regulatory bodies.


Q: Will Allomaron affect my ability to drive or operate machinery?

The official safety label includes adverse events that affect the central nervous system (CNS), such as mild fatigue and occasional dizziness (if reported). The occurrence of such effects may potentially affect concentration or reaction time. Regulatory documents generally recommend being aware of how the medicine affects an individual before engaging in activities requiring concentration.


Q: Does Allomaron cause dependency or withdrawal symptoms?

The official labeling does not classify this medicine as one with a high risk of causing dependency or withdrawal symptoms.


Q: What should I do if I have an allergic reaction to Allomaron?

The official safety label specifically documents the risk of severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson Syndrome (SJS). The presence of these documented risks indicates that any sign of a severe allergic reaction, particularly a rash, warrants immediate communication with a healthcare professional.


Q: What are the signs that Allomaron is actually working for me?

The medicine's purpose is to achieve a target level of serum uric acid concentration. This measurable level is the key objective index used to monitor the medicine's effectiveness. Official guidance emphasizes that professional monitoring of uric acid levels is how the therapeutic goal is confirmed.


Q: Can Allomaron be split, crushed, or chewed?

Allomaron is provided as a tablet intended for oral administration. The official administration section does not contain instructions that allow for the scoring, splitting, crushing, or chewing of the tablet.


Q: Are there any specific foods or beverages that must be avoided with Allomaron?

The official instructions indicate that the medicine should be taken after a meal to enhance gastrointestinal tolerance. However, official regulatory documents do not formally list any specific food groups that must be avoided entirely when using Allomaron.


Q: Does Allomaron have a potential for abuse?

The official labeling does not classify this medicine as one with a high risk of abuse potential or dependency. The active ingredients are not typically scheduled as controlled substances.


Q: Is Allomaron a drug that is eliminated quickly from the body?

The official regulatory label includes a detailed pharmacokinetics section. This section describes the drug's half-life and elimination route, which are objective measures indicating the rate at which the body removes the active ingredients after use.


Q: Can a minor side effect become a serious problem while taking Allomaron?

Official safety notes categorize adverse reactions into two distinct groups: Common Reactions (like skin rash or nausea) and separate Serious Adverse Reactions (such as SJS or hepatotoxicity). This categorization, which is based on incidence observed in clinical use, defines the specific serious risks associated with the medicine.


Q: Can Allomaron affect fertility in men or women?

The Special Populations section of the official label provides specific constraints regarding use in women who are pregnant or breastfeeding. These are the primary reproductive health constraints noted in the official product information.

How should Allomaron be stored and disposed of?

How to Store and Dispose of Allomaron?

The storage and disposal instructions for Allomaron are structured to maintain drug stability and prevent misuse or accidental exposure, in line with official regulatory guidelines.

Storage Component Requirement
Temperature Store at controlled room temperature, typically 20 C to 25 C (68 F to 77 F).
Protection Keep the product in the original container, tightly closed, protected from moisture and excessive humidity. Do not freeze.
In-Use Stability Discard any reconstituted product that has not been used within the defined period (e.g., 6 hours) unless otherwise specified in the official labeling.
Access Control Store the medicine securely, out of the sight and reach of children and pets, preferably in a locked cabinet.

Disposal Instructions: The primary method for disposal is to use an authorized drug take-back program or official collection kiosk. If a take-back program is not available, the medicine should be mixed with an unappealing substance, such as used coffee grounds or cat litter, sealed in a bag or container, and placed in the household trash. The labeling must be consulted to determine if the product is on the official list of medicines recommended for flushing.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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