×
Components:
Chloramphenicol
Method of action:
Bacteriostatic, Ophthalmologicals
Available in countries
See all
close
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 2019.12.06

Name of the medicinal product

Klornik

Qualitative and quantitative composition

Chloramphenicol

Therapeutic indications

The information provided in Therapeutic indications of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

Klornik is a broad spectrum bacteriostatic antibiotic. It is active against a wide range of Gram-negative and Gram-positive organisms, including Salmonella typhi, Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae and Bacteroides fragilis. It has antirickettsial and antichlamydial activity. It is indicated for the topical treatment of superficial ocular infections caused by pathogens which are sensitive to it.

Klornik is indicated in adults and children.

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

Posology

Adults (and the elderly) and children

One or two drops applied to each affected eye up to six times daily or more frequently if required. (Severe infections may require one to two drops every fifteen to twenty minutes initially, reducing the frequency of instillation gradually as the infection is controlled).

Paediatric population

Dosage adjustment may be necessary in newborn infants because of reduced systemic elimination due to immature metabolism and the risk of dose-related adverse effects. The maximum duration of treatment is 10-14 days.

Method of administration

For topical ocular use.

Contraindications

The information provided in Contraindications of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

-

- Myelosuprresssion during previous exposure to Klornik.

- Known personal or family history of blood dyscrasias including aplastic anaemia

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

Klornik is absorbed systemically from the eye and toxicity has been reported following chronic exposure.

Bone marrow hypoplasia, including aplastic anaemia and death, has been reported following topical use of Klornik. Whilst the hazard is a rare one, it should be borne in mind when assessing the benefits expected from the use of the compound.

Where Klornik eye drops are used on a long term or intermittent basis, it may be advisable to perform a routine blood profile before therapy and at appropriate intervals thereafter to detect any haemopoietic abnormalities.

In severe infections topical use of Klornik should be supplemented with appropriate systemic treatment.

Prolonged use should be avoided as it may increase the likelihood of sensitisation and the emergence of resistant organisms.

If any new infection appears during the treatment, the antibiotic should be discontinued and appropriate measures taken. Klornik should be reserved for use only in infections for which it is specifically indicated.

Klornik Eye Drops does not provide adequate coverage against Pseudomonas aeruginosa and Serratia marcescens.

Do not use for more than 5 days without consulting a doctor.

Medical advice should be sought if there is no improvement in the condition after 2 days or if symptoms worsen at any time.

Patients should be referred to their doctor if any of the following apply:

- Disturbed vision

- Severe pain within the eye

- Photophobia

- Eye inflammation associated with a rash on the scalp or face

- The eye looks cloudy

- The pupil looks unusual

- Suspected foreign body in the eye

Patients should also be referred to their doctor if any of the following in his/her medical history apply:

- Previous conjunctivitis in the recent past

- Glaucoma

- Dry eye syndrome

- Eye surgery or laser treatment in the last 6 months

- Eye injury

- Current use of other eye drops or eye ointment

- Contact lens use

Soft contact lenses should not be worn during treatment with Klornik eye drops due to absorption of the preservative onto the lens which may cause damage to the lens. It is recommended that all types of contact lenses be avoided during ocular infections.

The packaging will convey the following information:

- If symptoms do not improve within 48 hours talk to your doctor

- Seek further immediate medical advice at any time if symptoms worsen

- Do not use if you are allergic to Klornik or any of the ingredients

Phenylmercuric nitrate is irritating to the skin. Topical application to eyes has been associated with mercurialentis and atypical band keratopathy.

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

The use of the eye drops may cause transient blurring of vision. Patients should not drive or operate hazardous machinery unless vision is clear.

Undesirable effects

The information provided in Undesirable effects of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

Eye disorders:

Transient irritation, burning, stinging and sensitivity reactions such as itching and dermatitis.

Immune System Disorders:

Hypersensitivity reactions including angioedema, anaphylaxis, urticaria, fever, vesicular and maculopapular dermatitis.

Blood and lymphatic system disorders:

Bone marrow depression and rarely aplastic anaemia has been reported following topical use of Klornik. Whilst the hazard is a rare one, it should be borne in mind when assessing the benefits expected from the use of this compound.

Reporting of suspected adverse reactions:

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via Yellow card scheme at www.mhra.gov.uk/yellowcard.

Overdose

The information provided in Overdose of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

Accidental ingestion of the drops is unlikely to cause systemic toxicity due to the low content of the antibiotic in the product. If irritation, pain, swelling, lacrimation or photophobia occur after undesired eye contact, the exposed eye(s) should be irrigated for at least 15 minutes. If symptoms persist after this, an ophthalmological examination should be considered.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

Pharmacotherapeutic group: Antibiotics

ATC code: S01AA01

Klornik is a broad spectrum antibiotic with bacteriostatic activity and is effective against a wide range of gram-negative and gram-positive organisms including Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus, Streptococcus viridans, Moraxella species and Enterobacteriaceae, the main pathogens responsible for acute bacterial conjunctivitis. Klornik exerts its antibacterial effect by reversibly binding to bacterial ribosomes thereby inhibiting bacterial protein synthesis.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

Evidence suggests that Klornik is absorbed systemically via topical ocular administration. Any Klornik that is absorbed will be widely distributed in the body tissues and fluids. It is found in cerebrospinal fluid, is secreted in saliva, with the highest concentrations occurring in the kidneys and liver.

Klornik also diffuses across the placenta into the foetal circulation and into breast milk.

Klornik is excreted chiefly in the urine as the glucuronide with small amounts being excreted via the bile and faeces. It has a reported half life of 1.5 to 5 hours which is increased in patients with liver impairment and neonates to between 24 and 28 hours in the latter.

Pharmacotherapeutic group

The information provided in Pharmacotherapeutic group of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Pharmacotherapeutic group in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close
Antibiotics

Preclinical safety data

The information provided in Preclinical safety data of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

No additional data of relevance to the prescriber.

Incompatibilities

The information provided in Incompatibilities of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

None known

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of Klornik is based on data of another medicine with exactly the same composition as the Klornik of the medicine (Chloramphenicol). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Klornik directly from the package or from the pharmacist at the pharmacy.
more... close

No special requirements.

Site feedback

How easy to use our site?

Commentary is required, without it we won't know how to become better
The maximum length of review is 1000 symbols

Thanks!

You help us to become better