Comtrex Cold

Comtrex Cold is effective in treating the

symptoms of common cold, flu, and hay fever including

sneezing, runny nose, sinus and nasal congestion (stuffy

nose), fever, headache, aches, itchy and watery eyes, and

general discomfort.

Acetaminophen (Comtrex Cold) is a pain reliever and fever reducer.

Chlorpheniramine (Comtrex Cold) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine (Comtrex Cold) is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Acetaminophen (Comtrex Cold), Chlorpheniramine (Comtrex Cold), and Pseudoephedrine (Comtrex Cold) is a combination medicine used to treat headache, fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Acetaminophen (Comtrex Cold), Chlorpheniramine (Comtrex Cold), and Pseudoephedrine (Comtrex Cold) may also be used for purposes not listed in this medication guide.

See also:
What is the most important information I should know about Comtrex Cold?

Comtrex Cold should not be used in patients who have previously exhibited hypersensitivity to aspirin and/or nonsteroidal antiinflammatory agents. Comtrex Cold should not be given to patients with a recent history of gastrointestinal bleeding or in patients with bleeding disorders (e.g., hemophilia).

Use Comtrex Cold liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Comtrex Cold liquid may be taken with food if it upsets your stomach.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Comtrex Cold liquid and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Comtrex Cold liquid.

See also:
What other drugs will affect Comtrex Cold?

Uricosuric Agents: Comtrex Cold may decrease the effects of probenecid, sulfinpyrazone, and phenylbutazone. Alcohol: Has a synergistic effect with aspirin in causing gastrointestinal bleeding. Corticosteroids: Concomitant administration with aspirin may increase the risk of gastrointestinal ulceration and may reduce serum salicylate levels. Pyrazolone Derivatives (phenylbutazone, oxyphenbutazone, and possibly dipyrone): Concomitant administration with aspirin may increase the risk of gastrointestinal ulceration. Nonsteroidal Antiinflammatory Agents: Comtrex Cold is contraindicated in patients who are hypersensitive to nonsteroidal anti-inflammatory agents. Urinary Alkalinizers: Decrease aspirin effectiveness by increasing the rate of salicylate renal excretion. Phenobarbital: Decreases aspirin effectiveness by enzyme induction. Phenytoin: Serum phenytoin levels may be increased by aspirin. Propranolol: May decrease aspirins anti-inflammatory action by competing for the same receptors. Antacids: Enteric Coated Comtrex Cold should not be given concurrently with antacids, since an increase in the pH of the stomach may effect the enteric coating of the tablets.

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What are the possible side effects of Comtrex Cold?

Paracetamol may cause pancreatitis, allergic reactions in the form of a rash or blood disorders (including neutropenia, pancytopenia, leucopenia, agranulocytosis and thrombocytopenia). These should disappear on stopping the treatment. The rash usually appears as red areas or allergic wheals, and may be accompanied by fever and involvement of the mucous membranes.

The most common side-effect due to Chlorpheniramine (Comtrex Cold) is sedation varying from slight drowsiness to deep sleep, including lassitude, dizziness, and inco-ordination. Paradoxical central nervous system stimulation may occur especially in children, with insomnia, nervousness, euphoria, irritability, tremors, and less frequently, nightmares, hallucinations, and convulsions.

Other side effects may include dry mouth; thickened respiratory tract secretions and tightness of the chest, blurred vision, urinary difficulty and retention, constipation and increased gastric reflux. In addition, gastro-intestinal disturbances may occur such as nausea, vomiting, diarrhoea or epigastric pain.

Hypersensitivity reactions may occur. Blood disorders including agranulocytosis, leucopenia, haemolytic anaemia and thrombocytopenia, have been reported. Other less frequently reported side-effects include hypotension, tinnitus, headache and paraesthesias.

Chloropheniramine should be given with care to patients with glaucoma, urinary retention, prostatic hypertrophy or pyloroduodenal obstruction. Caution is advised in patients with epilepsy and severe cardiovascular disorders.

Chlorpheniramine (Comtrex Cold) may enhance the sedative effect of central nervous system depressants including alcohol, barbiturates, hypnotic, analgesics, sedatives and tranquillisers. Care should be taken when taking medicines containing tricyclic anti-depressants or atropine together.

Elderly patients are more susceptible to the central nervous system depressant and lowering of blood pressure effects even at dose quantities effective for treatment.

The warning signs of damage caused by ototoxic medicines may be masked by Chlorpheniramine (Comtrex Cold).

Other central nervous system depressants, such as alcohol, barbiturates, hyponotics, narcotic analgesics, sedatives and tranquillisers, if taken together will increase the chance of sedation. Be careful when taking medicines containing tricyclic anti-depressants or atropine together.

Pseudoephedrine (Comtrex Cold) hydrochloride may cause giddiness, headache, nausea, vomiting, sweating, thirst, rapid or irregular heart beat (tachycardia, ventricular arrhythmia), pain in front of the heart (precordial pain), palpitations, raised blood pressure (hypertension), micturition, difficulty in urination, muscular weakness, tremors, anxiety, restlessness and inability to sleep, fear, confusion, psychotic states, reduced appetite, dyspnoea, sweating, hypersalivation, altered metabolism including disturbance in glucose metabolism. Tolerance with dependence may occur after continued use.

The effects of Pseudoephedrine (Comtrex Cold) hydrochloride are lessened by medicines containing guanethidine, reserpine, methyldopa and may be diminished or enhanced by tricyclic antidepressants. It may increase the possibility of irregular heart beat in patients taking digitalis.

Pseudoephedrine (Comtrex Cold) may increase blood pressure and therefore special care is advisable in patients receiving antihypertensive therapy.

The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Comtrex Cold also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)