Clotrimazolo Farmakopea

Clotrimazolo Farmakopea Venous stomatitis.

Fungal lesions of the skin and mucous membranes caused by dermatophytes, mold and yeast-like fungi, multi-colored lichen, erythrasma, candidiasis vulvovaginitis, trichomoniasis, mycoses complicated by secondary pyoderma, sanitation of the birth canal before childbirth.

Externally, the cream is applied in a thin layer to the affected areas of the skin 2-3 times a day and gently rubbed in. For a lesion the size of a palm, a column of cream 0.5 cm long is enough.

The duration of therapy is individual and depends on the severity and location of the disease. To achieve a complete recovery, do not stop treatment with the cream immediately after the disappearance of acute symptoms of inflammation or subjective complaints. The duration of therapy should be on average about 4 weeks.

With dermatomycosis-3-4 weeks, erythrasma-2-4 weeks, multi-colored lichen-1-3 weeks, candidiasis vulvitis and balanitis-1-2 weeks.

For fungal diseases of the skin of the legs, it is recommended to continue therapy for about 2 weeks after the symptoms of the disease are relieved.

Externally, intravaginally, the ointment is applied in a thin layer to the affected area of the skin 3 times a day until the subjective symptoms disappear, and for another 2 weeks. A single dose is a column of 5 mm per palm-sized surface area. For vaginal infections-enter deep into the vagina with an applicator 1 time per day. With candida vulvovaginitis and candida balanitis-2-3 times a day for 1-2 weeks. The total duration of treatment for dermatomycosis is 3-4 weeks, erythrasma-2-4 weeks, multi-colored lichen-1-3 weeks.

The drug is usually well tolerated. In rare cases, with hypersensitivity to the components of the drug, allergic reactions are noted — redness of the oral mucosa, a burning and tingling sensation at the site of application of the drug, urticaria.

If irritation occurs, the drug should be discontinued.

Allergic reactions: hyperemia, itching, rash.

Hypersensitivity to the components of the drug.

Hypersensitivity, pregnancy (I trimester).

Clotrimazole is an imidazole derivative, a broad-spectrum antifungal agent.

The antimycotic effect is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes a change in its structure and properties and leads to cell lysis.

To clotrimazole sensitive dermatophytes, yeast-like fungi (genus Candida, Torulopsis glabrata, Rhodotorula), mold fungi, as well as the causative agent of multi-colored lichen Pityriasis versicolor and the causative agent of erythrasma.

It has an antimicrobial effect against gram-positive (staphylococci and streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as in relation to Trichomonas vaginalis.

It has a wide spectrum of action. Active against dermatophytes, yeast fungi of the genus Candida, Corynebacterium minutissimum, Staphylococcus spp., Streptococcus spp., Trichomonas.

When applied topically, clotrimazole adsorption from the mucous membranes is negligible.

It is characterized by a high penetrating power. The concentration in the epidermis is higher than in the dermis and subcutaneous tissue. It has practically no systemic effect.

When used concomitantly with amphotericin B, nystatin, the activity of clotrimazole may decrease.

The effectiveness reduces nystatin.