Acneris-AD

Acneris-AD

Adapalene, Clindamycin Phosphate

Acne.

Externally, Before applying the Acneris-AD gel, it is necessary to clean and dry the skin. A light touch, evenly apply the gel to affected skin 1 time a day before bed, avoiding contact with eyes and lips.

The therapeutic effect develops after 1-4 weeks, the course of therapy-2-4 weeks. Persistent improvement — after 3 months of treatment. Repeated courses of treatment after consultation with a doctor.

The drug should be used only according to the method of use and in the doses specified in the instructions for use. With excessive application of the gel, the positive effect does not occur faster.

hypersensitivity to the components of the drug,

Crohn's disease, ulcerative colitis, pseudomembranous colitis, including in the anamnesis (with simultaneous systemic (oral, intravenous, intravenous) use of clindamycin),

pregnancy,

lactation period,

age up to 12 years (no safety and efficacy data available).

With caution: dermatitis, eczema, allergic diseases, simultaneous use of muscle relaxants.

From the skin and subcutaneous fat: dry skin, irritation, burning sensation, erythema, contact dermatitis, discomfort, sunburn at the site of application of the drug, peeling of the skin, skin soreness, swelling of the skin, increased production of sebaceous glands, urticaria.

On the part of the visual organ: irritation, itching and swelling of the eyelids, erythema in the eyelid area, burning sensation in the eyes.

From the digestive system: abdominal pain, gastrointestinal disorders (diarrhea, nausea, vomiting).

Other: allergic reactions, folliculitis, is caused by gram-negative flora, a possibility of development of pseudomembranous colitis.

In case of skin irritation, treatment should be suspended until the irritation disappears or the frequency of use should be reduced.

If you experience any of the above or other side effects not listed above, you should consult your doctor.

Unlikely. When applied topically, clindamycin can be absorbed in amounts that cause systemic effects.

Treatment: in case of accidental ingestion of the drug, it is necessary to wash the stomach and immediately consult a doctor. Conducting symptomatic and supportive therapy.

A combined drug for external use, the active ingredients of which are adapalene and clindamycin.

Adapalene - retinoid metabolite, which has an anti-inflammatory effect and pronounced comedonolytic activity (affects open and closed comedones), normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of the drug is based on the binding of adapalene to specific nuclear receptors of retinoic acid. Adapalene normalizes the process of differentiation of epithelial cells of follicles, thus reducing the formation of microcomedones. It suppresses chemotaxis and chemokinetic reactions of human polynuclear cells, as well as inhibits the metabolism of arachidonic acid and the formation of inflammatory mediators. Thus, we can say that under the influence of adapalene, the cell-mediated inflammatory component of acne decreases

Clindamycin - a bacteriostatic antibiotic from the lincosamide group, it has a wide spectrum of action, binds to the 50S subunit of the ribosomal membrane and suppresses protein synthesis in the microbial cell. Clindamycin phosphate after application to the skin is rapidly hydrolyzed by phosphatases in the ducts of the sebaceous glands to form clindamycin, which has antibacterial activity. The sensitivity of all the studied strains is shown Propionibacterium acnes to clindamycin in vitro (MPC 0.4 mcg / ml).

The absorption of adapalene through the skin is very low (about 4% of the applied dose). Excretion from the body occurs mainly with bile. After external administration of clindamycin phosphate, very low concentrations of clindamycin are detected in the blood serum and urine.

• Acne treatment agents [Dermatotropic agents in combinations]

Studies of interactions with other drugs have not been conducted. However, you should not simultaneously use other retinoids or antibiotics for external use, or drugs with a similar mechanism of action.

Caution should be exercised when using cosmetics with an exfoliating, irritating or drying effect at the same time because of the possible additional irritating effect.

The absorption of adapalene through the skin is low, so the development of interaction with drugs of systemic action is unlikely.

After external administration of clindamycin, very low concentrations of clindamycin are detected in the blood serum and urine.

There is cross-resistance of microorganisms to clindamycin and lincomycin.

Antagonism between clindamycin and erythromycin has been noted.

It has been established that clindamycin disrupts neuromuscular transmission and, therefore, may enhance the effect of other peripheral muscle relaxants, so the drug should be used with caution in patients receiving drugs of this group.

Concomitant administration with medications containing erythromycin is not recommended.