×

Acetilcolina Intraocular 1%

Components:
Acetylcholine Chloride
Method of action:
Diuretic, Ophthalmologicals
Available in countries
See all
close
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 2019.09.20

Name of the medicinal product

Acetilcolina Intraocular 1%

Qualitative and quantitative composition

Acetylcholine Chloride

Therapeutic indications

The information provided in Therapeutic indications of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

To obtain rapid and complete miosis after delivery of the lens in cataract surgery as well as in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid complete miosis is required.

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

Acetilcolina Intraocular 1%-E is for intraocular irrigation only. A freshly prepared 1% solution should be used in the anterior chamber of the eye during surgery.

Adults and Elderly: In most cases a satisfactory miosis, which will last for approximately 20 minutes, is produced in seconds by 0.5 - 2.0ml. A second application may be made at the discretion of the surgeon if prolonged miosis is required.

Children:

Safety and effectiveness in children has not been established.

Route of administration: Intraocular irrigation during surgery.

Contraindications

The information provided in Contraindications of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

There are no known contra-indications to the use of Acetilcolina Intraocular 1%-E in cataract or anterior segment surgery.

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

If miosis is to be obtained quickly and completely, obstructions to miosis such as anterior or posterior synechiae may require surgery prior to administration of Acetilcolina Intraocular 1%-E. In cataract surgery Acetilcolina Intraocular 1%-E should be used only after delivery of the lens.

If blister or paper backing is damaged or broken, sterility of the Acetilcolina Intraocular 1%-E vial cannot be assured. The solvent should be in the upper chamber before use. If the centre rubber plug in the univial does not go down when the plunger-stopper is pressed or is already down, the vial should not be used.

Aqueous solutions of Acetilcolina Intraocular 1%-E are unstable. The solution should therefore be prepared immediately before use. Any remainder should be discarded.

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

Not applicable.

Undesirable effects

The information provided in Undesirable effects of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

Adverse reactions which are indicative of systemic absorption have been reported rarely in the literature. Symptoms include bradycardia, hypotension, flushing, breathing difficulties and sweating. Isolated cases of corneal oedema, corneal clouding and corneal decompensation have been reported with the use of Acetilcolina Intraocular 1%-E, although a causal relationship has not been established.

Overdose

The information provided in Overdose of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

The symptoms of overdosage are likely to be effects resulting from systemic absorption, ie bradycardia, hypotension, flushing, breathing difficulties and sweating. Atropine sulphate (0.5 - 1mg) should be given intramuscularly or intravenously and should be readily available to counteract possible overdosage. Adrenaline (0.1 - 1mg subcutaneously) is also of value in overcoming severe cardiovascular or bronchoconstrictor responses.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

Acetylcholine is a physiological neuromediator of postganglionic parasympathetic nerve fibres (muscarinic action), skeletal muscles and ganglia of the sympathetic system (nicotinic action).

The ocular parasympathetic receptors of the muscarinic type are very numerous and localised:

- at the level of the pupillary sphincter, whose contraction causes miosis

- at the level of the ciliary muscle, whose contraction allows accommodation and facilitates the flow of the aqueous humor by opening of the trabecular meshwork. In addition, the acetylcholine can have an inhibitory effect on the aqueous secretion. These two last factors result in a decrease in the intraocular pressure.

- at the level of the lacrimal glands, whose stimulation causes tearing.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

Topical: Not applicable.

Preclinical safety data

The information provided in Preclinical safety data of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

The active ingredient of Acetilcolina Intraocular 1%-E is acetylcholine, a natural neurohormonal transmitter the pharmacological activity and toxicity of which have been clearly defined. The effect of Acetilcolina Intraocular 1% has been demonstrated in several animal studies. The addition of electrolytes in Acetilcolina Intraocular 1%-E resulted in very good local tolerability in the cat. Given that a low single dose of acetylcholine is administered by the intraocular route, the risk of systemic toxicity is very low.

Incompatibilities

The information provided in Incompatibilities of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

None known. The filter hub is recommended only for use with Acetilcolina Intraocular 1%-E.

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of Acetilcolina Intraocular 1% is based on data of another medicine with exactly the same composition as the Acetilcolina Intraocular 1% of the medicine (Acetylcholine Chloride). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Acetilcolina Intraocular 1% directly from the package or from the pharmacist at the pharmacy.
more... close

The reconstituted preparation is a clear, colourless solution.

Warning: Do not use if blister or peelable backing is damaged or broken. Open under aseptic conditions only. The contents of the blister can be guaranteed as sterile.

Directions for preparing Acetilcolina Intraocular 1%-E

1. Inspect unopened blister to ensure that it is intact. Peel open blister.

2. Aseptically transfer the ampoule, vial and syringe tip filter hub to sterile field. Maintain asepsis during preparation of solution.

3. Aseptically attach a sterile 18 to 20 gauge, bevelled needle to the luer tip of a sterile disposable syringe with twisting motion to assure secure fit.

4. Break open the ampoule containing the solvent. The One Point Cut (OPC) ampoule must be opened as follows: Hold the bottom part of the ampoule with the thumb pointing to the coloured point. Grasp the top of the ampoule with the other hand, positioning the thumb at the coloured point and press back to break at the existing cut under the point.

5. Remove the needle protector and withdraw the solvent from the ampoule into the syringe. Discard ampoule.

6. Remove and discard plastic cap from top of vial.

7. Insert the needle through the centre of the vial stopper.

8. Transfer the solvent from the syringe to the vial.

9. Shake gently to dissolve drug.

10. Slowly withdraw the solution from the vial through the needle into the syringe.

11. Discard needle.

12. Aseptically open tip filter hub pouch.

13. Aseptically attach filter hub onto luer tip of syringe with a twisting motion to assure secure fit.

14. Aseptically attach a sterile blunt tip irrigation cannula to male luer of filter prior to intraocular irrigation.

15. Discard appropriately after use. Do not reuse the filter hub.

The solution must be mixed just before use since aqueous solutions of acetylcholine are unstable. Only clear and colourless solutions should be used.

Acetilcolina Intraocular 1%-E should not be re-sterilised. The filter hub is recommended only for use with Acetilcolina Intraocular 1%-E. Aspiration through the filter is not recommended. However, if utilised, discard needle and syringe filter to prevent recontamination of fluids during injection.

Do not aspirate and inject through the same filter.

Do not use unless a clear and colourless solution is produced. For single use only. Discard any unused solution.