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Medically reviewed by Oliinyk Elizabeth Ivanovna, PharmD. Last updated on 01.04.2022
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Acclean Plus (Sodium Fluoride)
Sodium Fluoride
Primary Osteoporosis (postmenopausal, presenil, senile, idiopathic), steroid osteoporosis (prevention and treatment), special forms of local osteopathy.
Inside, after eating, swallow whole, drink a small amount of liquid-40 mg 2 times a day (morning and evening) for 1 year, with arthralgia against the background of Acclean Plus (sodium Fluoride)and an intermittent course (3 months therapy — 3 months break) is possible.
Prevention of steroid osteoporosis: 40 mg / day. The maximum single dose is 80 mg. the duration of treatment is at least 4 years.
Severe disorders of liver or kidney function, childhood and adolescence, growth period, pregnancy, lactation.
On the part of the gastrointestinal organs: rarely, nausea.
From the musculoskeletal side: pain in the lower extremities and joints, in some cases with prolonged intake of fluoride in excessive doses, it is possible to develop osteosclerosis and/or ectopic calcification (especially when combined with vitamins A or D).
It should artificially induce vomiting, drink milk. Set gastric lavage with acidified water or 1% calcium chloride solution, sodium sulfate inside 30 G as a laxative, in/B — 20 ml of 10-20% calcium gluconate solution at intervals of 15-20 minutes. It is recommended to monitor calcium levels in the blood. For the Prevention of ventricular fibrillation, the prescription of procainamide or Lignocaine. Carrying out correction of dehydration and loss of sodium chloride, if necessary — anti-shock measures.
Absorbed from the gastrointestinal tract almost completely (93-97%). The speed of suction is affected by the degree of filling the stomach with food. Calcium, magnesium and aluminum ions form compounds with fluorine and slow down the absorption of the latter. Cmax in the blood plasma it is reached through 4 h.50% of the received fluorine is incorporated into the blood regardless of the dose. Accumulation in organs or soft tissues is not observed. The therapeutic concentration of fluoride in serum is 95-190 ng / ml, equivalent to 15-20 mg of fluorine ions. The state of equilibrium is achieved within three days after the daily intake of twice in a single dose of 40 mg, with a therapeutic concentration ranging from 130 to 220 ng/ml.Excreted by the kidneys.
- Macro and micronutrients
- Bone and cartilage metabolism correctors
Antacids reduce the effect (prematurely dissolve the shell), they should be taken in 2 h before.
