Components:
Ethambutol
Ethambutol
Method of action:
Anti-Tuberculosis, Chondroprotective
Anti-Tuberculosis, Chondroprotective
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Name of the medicinal product

Abbutol

Qualitative and quantitative composition

Ethambutol

Therapeutic indications

The information provided in Therapeutic indications of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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For the primary treatment and re-treatment of tuberculosis and for prophylaxis in cases of inactive tuberculosis or large-tuberculin-positive reaction.

Abbutol should only be used in conjunction with other anti-tuberculosis drugs to which the patient's organisms are susceptible.

Consideration should be given to official guidance on the appropriate use of antimicrobial agents.

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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Posology

For oral use.

Dosage should be determined according to the body weight of the patient. The usual daily dosage is 15-25mg/kg body weight given as a single dose.

Abbutol should not be used as a sole anti-tuberculosis agent, but should be given with at least one other anti-tuberculosis drug to avoid development of resistant strains.

Adults

For primary treatment and prophylaxis: Abbutol should be administered in a single daily dose of 15 mg/kg body weight; concomitant drugs should be maintained at their usual recommended dosage.

For re-treatment: For the first 60 days of treatment, Abbutol should be administered in a single daily dose of 25 mg/kg body weight. Thereafter the dosage should be reduced to 15 mg/kg body weight; concomitant drugs should be maintained at their usual recommended dosage levels.

Children

For primary treatment and re-treatment: For the first 60 days of treatment, a single daily dose of 25 mg/kg body weight. Thereafter the dosage should be reduced to 15 mg/kg body weight; concomitant drugs being maintained at their usual recommended dosage levels.

For prophylaxis: A single daily dose of 15 mg/kg body weight; concomitant drugs being maintained at their usual recommended dosage levels.

As children may be less likely or unable to report ocular toxicity, particular caution may be warranted .

Older people Dosage as for adults. However, patients with decreased renal function may need to have the dosage adjusted as determined by blood levels of Abbutol.

Contraindications

The information provided in Contraindications of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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Known hypersensitivity to Abbutol or to any of the other ingredients.

Known optic neuritis or retrobulbar neuritis, unless clinical judgement determines that the benefit outweighs the potential risk.

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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Ocular toxicity:

Abbutol causes ocular toxicity and patients should be advised to report any changes of visual acuity. It is recommended that patients undergo a full ophthalmic examination before starting treatment. This should include visual acuity, colour vision, perimetry and ophthalmoscopy. and should be monitored every four weeks during treatment. For patients with pre-existing visual defects or renal insufficiency the frequency of tests should be increased to every second or third week or more, depending on clinical assessment. Each eye should be tested separately as ocular toxicity can be unilateral or bilateral. Opthalmologic examination should include tests for black-white/chromatic visual acuity (e.g Snellen eye chart and 65-test) and opthalmoscopy.

Patients who are unable to report their visual acuity should be more closely monitored for any signs of deterioration during treatment with Abbutol. Abbutol should be used in young children and those with language or communication difficulties, where appropriate, with advice concerning the need to report visual side-effects being given to parents or other family members. However, routine ophtalmological examinations may be considered desirable when treating young children

Abbutol therapy should be stopped immediately if visual disturbances are observed .

Renal impairment:

Renal function should be checked before treatment with antituberculosis drugs and appropriate dosage adjustments made. Abbutol should preferably be avoided in patients with renal impairment, but if used the dose should be reduced and the plasma-drug concentration monitored. Toxic effects are more common if renal function is impaired.

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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Abbutol may produce a unique type of visual impairment . Numbness and paraesthesia of the extremities has been reported. Therefore, patients should be advised not to drive or operate machinery if they experience any of these effects.

Undesirable effects

The information provided in Undesirable effects of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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The most important adverse effect resulting from Abbutol use is retrobulbar neuritis with a reduction in visual acuity.

The adverse event data below contains all reactions that are considered at least possibly related to Abbutol and is based on data collected, mainly from published literature post authorisation. The undesirable effects have been arranged by body system, organ class and absolute frequency, and are defined using the following convention:

Very common ≥1/10); common ≥1/100, < 1/10); uncommon ≥1/1,000, < 1/100); rare ≥1/10,000, < 1/1,000); very rare (< 1/10,000)

SOC

LLT

Occurrence

Blood and lymphatic system disorders:

thrombocytopenia, leukopenia, neutropenia, eosinophilia

Very rare

Immune system disorders

hypersensitivity, allergic reactions, anaphylaxis, allergic pneumonitis.

Very Rare

Metabolism and nutrition disorders

hyperuricaemia.

Very common

gout.

Very rare

Psychiatric disorders

confusion, disorientation, hallucination

Very rare

Nervous system disorders

visual disturbances caused by optic neuritis (retrobulbar neuritis)*

Common

peripheral neuritis, peripheral neuropathy, paraesthesia (especially in the extremities), numbness

rare

burning pain, weakness (hands and feet), dizziness, headache, eye disorders

Very rare

tremor

Unknown

Respiratory, thoracic and mediastinal disorders

pneumonitis, pulmonary infiltrates, with or without eosinophilia

Very rare

Gastrointestinal disorders:

metallic taste, nausea, vomiting, anorexia, flatulence, abdominal pain, diarrhoea, loss of appetite, upset stomach.

Not known

1Hepatobiliary disorders:

hepatitis, jaundice, transient increase in liver enzymes

Not known

hepatic failure,

Very rare

Skin & subcutaneous tissue disorders

rash, pruritus, urticaria,

rare

photosensitive lichenoid eruptions, bullous dermatitis, Stevens Johnson syndrome, epidermal necrolysis.

Very rare

Renal and urinary disorders:

nephrotoxicity including interstitial nephritis.

Very rare

General disorders and administration site conditions:

malaise, joint pains, pyrexia.

Very rare

* This effect is thought to be dose related, and frequency is dependent on both dose and duration of treatment. It occurs most frequently with doses of 25 mg/kg body weight and after two months of therapy, however optic neuritis has also occurred after only a few days of therapy. The effect is often reversible upon discontinuation of therapy. To avoid permanent damage visual acuity should be checked regularly during treatment and therapy discontinued immediately when visual disturbances occur. Visual disturbances may be unilateral or bilateral; therefore each eye should be tested separately . Typical signs include: blurred vision, eye pain, impairment of colour vision (red-green colour blindness), constriction of visual field (central or peripheral scotoma), and any loss in vision. Recovery of visual acuity has usually occurred over a period of weeks to months after the drug was discontinued, and patients have then received Abbutol at lower dosage without toxicity

1Liver function tests should be performed in patients who develop symptoms suggestive of hepatitis or who become generally unwell during treatment.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard

Overdose

The information provided in Overdose of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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Symptoms: Gastrointestinal disturbances, vomiting, fever, headache, anorexia, dizziness, hallucinations and/or visual disturbances.

Treatment: There is no specific antidote, but gastric lavage should be employed if necessary.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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ATC Code : J04AK02 - Other drugs for treatment of tuberculosis

Abbutol is bacteriostatic. It is effective against Mycobacterium tuberculosi and M.bovis with an MIC of 0.5 – 8µg per ml. The exact mechanism of action is unknown. While it has activity against some atypical mycobacteria including M.Kansasii, activity against other micro-organisms has not yet been reported.

It is effective against tubercle bacilli resistant to other tuberculostatics.

Cross-resistance has not yet been reported. Primary resistance to Abbutol is uncommon but resistant strains of M.tuberculosis are readily produced if Abbutol is used alone.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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Absorption: Abbutol is readily absorbed after oral administration and this absorption is not significantly impaired by food.

Distribution: After a single oral dose of 25 mg/kg bodyweight, within 4 hours peak plasma concentrations of up to 5µg/ml are obtained, by 24 hours the concentration decreases to less than 1µg/ml. Abbutol readily diffuses into red blood cells and into the cerebrospinal fluid when the meninges are inflamed. It has also been reported to cross the placenta.

Metabolism and Excretion: Most of a dose is excreted unchanged in the urine and up to 20% in the faeces, within 48 hours. From 8 – 15% of a dose appears in the urine as inactive metabolites.

Preclinical safety data

The information provided in Preclinical safety data of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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Abbutol has been shown to be teratogenic in pregnant mice and rabbits when given in high doses. When pregnant mice or rabbits were treated with high doses of Abbutol hydrochloride, fetal mortality was slightly but not significantly (P>0.05) increased. Female rats treated with Abbutol hydrochloride displayed slight but insignificant (>0.05) decreases in fertility and litter size. In foetuses born of mice treated with high doses of Abbutol hydrochloride during pregnancy, a low incidence of cleft palate, exencephaly and abnormality of the vertebral column were observed. Minor abnormalities of the cervical vertebra were seen in the newborn of rats treated with high doses of Abbutol hydrochloride during pregnancy. Rabbits receiving high doses of Abbutol hydrochloride during pregnancy gave birth to two foetuses with monophthalmia, one with a shortened right forearm accompanied by bilateral wrist-joint contracture and one with hare lip and cleft palate.

Incompatibilities

The information provided in Incompatibilities of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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None.

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
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None.

Name of the medicinal product
Abbutol
Qualitative and quantitative composition
Ethambutol
Therapeutic indications
The information provided in Therapeutic indications of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

For the primary treatment and re-treatment of tuberculosis and for prophylaxis in cases of inactive tuberculosis or large-tuberculin-positive reaction.

Abbutol should only be used in conjunction with other anti-tuberculosis drugs to which the patient's organisms are susceptible.

Consideration should be given to official guidance on the appropriate use of antimicrobial agents.

Dosage (Posology) and method of administration
The information provided in Dosage (Posology) and method of administration of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

Posology

For oral use.

Dosage should be determined according to the body weight of the patient. The usual daily dosage is 15-25mg/kg body weight given as a single dose.

Abbutol should not be used as a sole anti-tuberculosis agent, but should be given with at least one other anti-tuberculosis drug to avoid development of resistant strains.

Adults

For primary treatment and prophylaxis: Abbutol should be administered in a single daily dose of 15 mg/kg body weight; concomitant drugs should be maintained at their usual recommended dosage.

For re-treatment: For the first 60 days of treatment, Abbutol should be administered in a single daily dose of 25 mg/kg body weight. Thereafter the dosage should be reduced to 15 mg/kg body weight; concomitant drugs should be maintained at their usual recommended dosage levels.

Children

For primary treatment and re-treatment: For the first 60 days of treatment, a single daily dose of 25 mg/kg body weight. Thereafter the dosage should be reduced to 15 mg/kg body weight; concomitant drugs being maintained at their usual recommended dosage levels.

For prophylaxis: A single daily dose of 15 mg/kg body weight; concomitant drugs being maintained at their usual recommended dosage levels.

As children may be less likely or unable to report ocular toxicity, particular caution may be warranted .

Older people Dosage as for adults. However, patients with decreased renal function may need to have the dosage adjusted as determined by blood levels of Abbutol.

Contraindications
The information provided in Contraindications of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

Known hypersensitivity to Abbutol or to any of the other ingredients.

Known optic neuritis or retrobulbar neuritis, unless clinical judgement determines that the benefit outweighs the potential risk.

Special warnings and precautions for use
The information provided in Special warnings and precautions for use of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

Ocular toxicity:

Abbutol causes ocular toxicity and patients should be advised to report any changes of visual acuity. It is recommended that patients undergo a full ophthalmic examination before starting treatment. This should include visual acuity, colour vision, perimetry and ophthalmoscopy. and should be monitored every four weeks during treatment. For patients with pre-existing visual defects or renal insufficiency the frequency of tests should be increased to every second or third week or more, depending on clinical assessment. Each eye should be tested separately as ocular toxicity can be unilateral or bilateral. Opthalmologic examination should include tests for black-white/chromatic visual acuity (e.g Snellen eye chart and 65-test) and opthalmoscopy.

Patients who are unable to report their visual acuity should be more closely monitored for any signs of deterioration during treatment with Abbutol. Abbutol should be used in young children and those with language or communication difficulties, where appropriate, with advice concerning the need to report visual side-effects being given to parents or other family members. However, routine ophtalmological examinations may be considered desirable when treating young children

Abbutol therapy should be stopped immediately if visual disturbances are observed .

Renal impairment:

Renal function should be checked before treatment with antituberculosis drugs and appropriate dosage adjustments made. Abbutol should preferably be avoided in patients with renal impairment, but if used the dose should be reduced and the plasma-drug concentration monitored. Toxic effects are more common if renal function is impaired.

Effects on ability to drive and use machines
The information provided in Effects on ability to drive and use machines of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

Abbutol may produce a unique type of visual impairment . Numbness and paraesthesia of the extremities has been reported. Therefore, patients should be advised not to drive or operate machinery if they experience any of these effects.

Undesirable effects
The information provided in Undesirable effects of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

The most important adverse effect resulting from Abbutol use is retrobulbar neuritis with a reduction in visual acuity.

The adverse event data below contains all reactions that are considered at least possibly related to Abbutol and is based on data collected, mainly from published literature post authorisation. The undesirable effects have been arranged by body system, organ class and absolute frequency, and are defined using the following convention:

Very common ≥1/10); common ≥1/100, < 1/10); uncommon ≥1/1,000, < 1/100); rare ≥1/10,000, < 1/1,000); very rare (< 1/10,000)

SOC

LLT

Occurrence

Blood and lymphatic system disorders:

thrombocytopenia, leukopenia, neutropenia, eosinophilia

Very rare

Immune system disorders

hypersensitivity, allergic reactions, anaphylaxis, allergic pneumonitis.

Very Rare

Metabolism and nutrition disorders

hyperuricaemia.

Very common

gout.

Very rare

Psychiatric disorders

confusion, disorientation, hallucination

Very rare

Nervous system disorders

visual disturbances caused by optic neuritis (retrobulbar neuritis)*

Common

peripheral neuritis, peripheral neuropathy, paraesthesia (especially in the extremities), numbness

rare

burning pain, weakness (hands and feet), dizziness, headache, eye disorders

Very rare

tremor

Unknown

Respiratory, thoracic and mediastinal disorders

pneumonitis, pulmonary infiltrates, with or without eosinophilia

Very rare

Gastrointestinal disorders:

metallic taste, nausea, vomiting, anorexia, flatulence, abdominal pain, diarrhoea, loss of appetite, upset stomach.

Not known

1Hepatobiliary disorders:

hepatitis, jaundice, transient increase in liver enzymes

Not known

hepatic failure,

Very rare

Skin & subcutaneous tissue disorders

rash, pruritus, urticaria,

rare

photosensitive lichenoid eruptions, bullous dermatitis, Stevens Johnson syndrome, epidermal necrolysis.

Very rare

Renal and urinary disorders:

nephrotoxicity including interstitial nephritis.

Very rare

General disorders and administration site conditions:

malaise, joint pains, pyrexia.

Very rare

* This effect is thought to be dose related, and frequency is dependent on both dose and duration of treatment. It occurs most frequently with doses of 25 mg/kg body weight and after two months of therapy, however optic neuritis has also occurred after only a few days of therapy. The effect is often reversible upon discontinuation of therapy. To avoid permanent damage visual acuity should be checked regularly during treatment and therapy discontinued immediately when visual disturbances occur. Visual disturbances may be unilateral or bilateral; therefore each eye should be tested separately . Typical signs include: blurred vision, eye pain, impairment of colour vision (red-green colour blindness), constriction of visual field (central or peripheral scotoma), and any loss in vision. Recovery of visual acuity has usually occurred over a period of weeks to months after the drug was discontinued, and patients have then received Abbutol at lower dosage without toxicity

1Liver function tests should be performed in patients who develop symptoms suggestive of hepatitis or who become generally unwell during treatment.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard

Overdose
The information provided in Overdose of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

Symptoms: Gastrointestinal disturbances, vomiting, fever, headache, anorexia, dizziness, hallucinations and/or visual disturbances.

Treatment: There is no specific antidote, but gastric lavage should be employed if necessary.

Pharmacodynamic properties
The information provided in Pharmacodynamic properties of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

ATC Code : J04AK02 - Other drugs for treatment of tuberculosis

Abbutol is bacteriostatic. It is effective against Mycobacterium tuberculosi and M.bovis with an MIC of 0.5 – 8µg per ml. The exact mechanism of action is unknown. While it has activity against some atypical mycobacteria including M.Kansasii, activity against other micro-organisms has not yet been reported.

It is effective against tubercle bacilli resistant to other tuberculostatics.

Cross-resistance has not yet been reported. Primary resistance to Abbutol is uncommon but resistant strains of M.tuberculosis are readily produced if Abbutol is used alone.

Pharmacokinetic properties
The information provided in Pharmacokinetic properties of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

Absorption: Abbutol is readily absorbed after oral administration and this absorption is not significantly impaired by food.

Distribution: After a single oral dose of 25 mg/kg bodyweight, within 4 hours peak plasma concentrations of up to 5µg/ml are obtained, by 24 hours the concentration decreases to less than 1µg/ml. Abbutol readily diffuses into red blood cells and into the cerebrospinal fluid when the meninges are inflamed. It has also been reported to cross the placenta.

Metabolism and Excretion: Most of a dose is excreted unchanged in the urine and up to 20% in the faeces, within 48 hours. From 8 – 15% of a dose appears in the urine as inactive metabolites.

Preclinical safety data
The information provided in Preclinical safety data of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

Abbutol has been shown to be teratogenic in pregnant mice and rabbits when given in high doses. When pregnant mice or rabbits were treated with high doses of Abbutol hydrochloride, fetal mortality was slightly but not significantly (P>0.05) increased. Female rats treated with Abbutol hydrochloride displayed slight but insignificant (>0.05) decreases in fertility and litter size. In foetuses born of mice treated with high doses of Abbutol hydrochloride during pregnancy, a low incidence of cleft palate, exencephaly and abnormality of the vertebral column were observed. Minor abnormalities of the cervical vertebra were seen in the newborn of rats treated with high doses of Abbutol hydrochloride during pregnancy. Rabbits receiving high doses of Abbutol hydrochloride during pregnancy gave birth to two foetuses with monophthalmia, one with a shortened right forearm accompanied by bilateral wrist-joint contracture and one with hare lip and cleft palate.

Incompatibilities
The information provided in Incompatibilities of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

None.

Special precautions for disposal and other handling
The information provided in Special precautions for disposal and other handling of Abbutol is based on data of another medicine with exactly the same composition as the Abbutol of the medicine (Ethambutol). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Abbutol directly from the package or from the pharmacist at the pharmacy.
more... close

None.

Available in countries
See all
close