Components:
Treatment option:
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 12.03.2022
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Top 20 medicines with the same components:
60-Second Fluoride Mint
Sodium Fluoride
Gel
Primary osteoporosis (postmenopausal, presenile, senile, idiopathic), steroid osteoporosis (prevention and treatment)
Inside, after eating, swallowed whole, washed down with a small amount of liquid-40 mg 2 times a day (morning and evening) for 1 year, with arthralgia against the background of taking 60-Second Fluoride Minta possible intermittent course (3 months of therapy — 3 months break).
Prevention of steroid osteoporosis: по 40 мг/сут. Максимальная разовая доза — 80 мг. Длительность лечения — не менее 4 лет.
Severe disorders of liver or kidney function, childhood and adolescence, growth period, pregnancy, lactation.
On the part of the gastrointestinal organs: редко — тошнота.
From the side of the musculoskeletal system: боль в нижних конечностях и суставах, в отдельных случаях при длительном приеме фторида в избыточных дозах возможно развитие остеосклероза и/или эктопической кальцификации (особенно при сочетании с витаминами A или D).
You should artificially provoke vomiting, drink milk. Install gastric lavage with acidified water or 1% calcium chloride solution%
Absorbed from the gastrointestinal tract almost completely (93-97%). The rate of absorption is affected by the degree of filling the stomach with food. Calcium, magnesium, aluminum ions form compounds with fluorine and slow the absorption of the latter. Cmax in blood plasma is reached after 4 h. 50% of the fluorine received is incorporated into the blood, regardless of the dose. Accumulation in organs or soft tissues is not observed. The therapeutic concentration of serum fluoride is 95-190 ng / ml, which is equivalent to 15-20 mg of fluorine ions. The steady state is achieved within three days after a single dose of 40 mg twice a day, the therapeutic concentration varies from 130 to 220 ng / ml. Excreted by the kidneys
- Macro and trace elements
- Correctors of bone and cartilage metabolism
The effect is reduced by antacids (prematurely dissolve the shell), they should be taken 2 hours earlier.
